Results 51 to 60 of about 1,953 (199)

Green Synthesis of Dihydropyrimidines and Pyridines Utilizing Biginelli Reaction [PDF]

, 2021
A novel approach to the synthesis of functionally substituted pyrazolopyrimidine, utilizing Ultrasound irradiation (US), microwave energy, and reaction under pressure in Q-tube as green and environmentally friendly techniques. The reaction time and yield
Khadijah M. Al-Zaydi (11680831), Modi Al-Boqami (11680834), Noha M. H. Elnagdi (11680837)   +2 more
core   +1 more source

Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

Molecules, 2000
A conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.
Birgit Jauk, Tetiana Pernat, C. Oliver Kappe   +2 more
doaj   +1 more source

Biginelli dihydropyrimidines and their acetylated derivatives as L-/T-type calcium channel blockers: Synthesis, enantioseparation, and molecular modeling studies. [PDF]

Arch Pharm (Weinheim)
Biginelli dihydropyrimidines (DHPM) were designed and synthesized (GD1–GD14), and their binding mechanism to L‐(Cav1.2)/T‐(Cav3.2) type calcium channels was illuminated by advanced molecular modeling techniques. Abstract Biginelli dihydropyrimidines (DHPMs) are considered superior over 1,4‐dihydropyridines (DHPs) in terms of both light and metabolic ...
Gündüz MG, Dengiz C, Denzinger K, Huang S, Lee JT, Nafie JW, Armstrong DW, Wolber G, Zamponi GW.   +8 more
europepmc   +2 more sources

FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction [PDF]

, 2020
A facile and highly efficient FeF3-catalyzed method has been developed for the direct synthesis of functionalized dihydropyrimidines from readily available starting materials via Biginelli reaction.
Krishna, Thalishetti, Laxminarayana, Eppakayala, Kalita, Dipak   +2 more
core   +1 more source

Innovating Electrosynthesis From Metal Electrodeposition to Organic Chemistry: Deep Eutectic Solvents as Efficient and Sustainable Media

ChemSusChem, Volume 19, Issue 11, 15 June 2026.
This review analyzes deep eutectic solvents (DESs) as efficient media for both organic and inorganic electrosynthesis. The improvements in terms of synthetic opportunities and sustainability are discussed, by exploring the multiple roles of DESs as solvents, electrolytes, and promoters, enabling effective and selective electrosynthesis under mild and ...
Cristiana Margarita, Stefano Nejrotti, Alejandro Leal‐Duaso, Marta Feroci, Alessandra Sanson, Claudia Barolo, Matteo Bonomo   +6 more
wiley   +1 more source

Síntese do monastrol e novos compostos de Biginelli promovida por In(OTf)3 Synthesis of monastrol and of new Biginelli compounds promoted by In(OTf)3

Química Nova, 2005
In this paper, we describe a practical route for the synthesis of Biginelli compounds using In(OTf)3. To study the generality of this catalyst, several examples using aromatic aldehydes, 1,3-dicarbonyl compounds, urea, and thiourea were investigated. The
Marla N. Godoi, Hellen S. Costenaro, Eliane Kramer, Paola S. Machado, Marcelo G. Montes D'Oca, Dennis Russowsky   +5 more
doaj   +1 more source

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

Lanthanide Triflate Catalyzed Biginelli Reaction. One-Pot Synthesis of Dihydropyrimidinones under Solvent-Free Conditions [PDF]

, 2016
Lanthanide Triflate Catalyzed Biginelli Reaction.
Limin Wang (87511), Min Yang (146229), Yun Ma (119475), Changtao Qian (2641480)   +3 more
core   +1 more source

Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis

Chemistry – A European Journal, Volume 32, Issue 9, 2 March 2026.
Mechanochemistry offers a sustainable, solvent‐free alternative to traditional synthesis, often enhanced by additives in a process known as additive‐assisted grinding. This review discusses how various additives, including liquids, ionic solids, and advanced materials like ionic liquids and piezoelectric compounds, improve reaction efficiency ...
Johanna Breinsperger, Nika Podlesnik, Francesco Mele, Michael Schnürch   +3 more
wiley   +1 more source

Nitrogen‐Rich, Tröger's Base‐Linked Porous Organic Polymers (POPs) as Heterogeneous Catalysts and Adsorbents of Organic Pollutants From Water

Journal of Applied Polymer Science, Volume 143, Issue 3, January 15, 2026.
Synthesized Tröger's based POPs showed great versatility in heterogeneous catalysis reactions and for pollutant adsorption. ABSTRACT Porous organic polymers are a new class of polymeric materials that combine permanent porosity, high surface area, monomer diversity, and synthetic tunability, making them highly promising candidates for application in ...
Tiago F. Machado, Saúl Vallejos, Artur J. M. Valente, M. Elisa Silva Serra, Dina Murtinho   +4 more
wiley   +1 more source