Results 51 to 60 of about 2,041,750 (198)

Exploring a Ugi‐Mediated Polymerization‐Induced Self‐Assembly Approach to Peptoid Particles

Macromolecular Rapid Communications, EarlyView.
Ugi‐mediated polymerization‐induced self‐assembly (U‐PISA) enables the one‐pot synthesis of PEG‐stabilized polypeptoid nanoparticles under mild aqueous conditions. By tuning PEG molar mass and feed composition, tunable spherical and worm‐like nano‐objects are obtained.
Thi Phuong Thu Nguyen, Maria Cristina Molaro, Hao‐Ning Tien, Lei Lei, Pierre Stiernet, Clemence Le Coeur, Federica Sodano, Antoine Debuigne, Benoit Couturaud   +8 more
wiley   +1 more source

Development of Dithioacetal‐Modified Dihydropyrimidone Derivatives with Potential Anti‐Inflammatory Activity for Inflammatory Bowel Disease

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This study designed and synthesized dithioacetal‐modified dihydropyrimidinone derivatives (30). Compound D3 showed optimal anti‐inflammatory activity, inhibiting the MAPK/NF‐κB pathway, reducing NO secretion (IC50 = 1.2 µM), and ameliorating DSS‐induced acute colitis in mice, offering a new candidate for inflammatory bowel disease therapy.
Jian‐Wei Jiang, Rui Dong, Qi Cao, Huan Wang, Si‐Yu Li, Guo‐Ping Zhang, Qian‐Yi Wang   +6 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Innovating Electrosynthesis From Metal Electrodeposition to Organic Chemistry: Deep Eutectic Solvents as Efficient and Sustainable Media

ChemSusChem, Volume 19, Issue 11, 15 June 2026.
This review analyzes deep eutectic solvents (DESs) as efficient media for both organic and inorganic electrosynthesis. The improvements in terms of synthetic opportunities and sustainability are discussed, by exploring the multiple roles of DESs as solvents, electrolytes, and promoters, enabling effective and selective electrosynthesis under mild and ...
Cristiana Margarita, Stefano Nejrotti, Alejandro Leal‐Duaso, Marta Feroci, Alessandra Sanson, Claudia Barolo, Matteo Bonomo   +6 more
wiley   +1 more source

Synthesis of novel adamantane-containing dihydropyrimidines utilizing Biginelli condensation reaction

, 2023
Novel dihydropyrimidines incorporating an adamantane motif have been synthesized using a three-component Biginelli reaction of adamantane-containing β-keto amide N-1-adamantyl acetoacetamide as active methylene compound, thiourea, and aromatic aldehydes ...
Adeleh Moshtaghi Zonouz (14423510), Mina Abkar Aras (14423507)   +1 more
core   +1 more source

Diethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and Ethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Molbank, 2012
Diethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine- 3,5-dicarboxylate and ethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate were obtained simultaneously by the Biginelli ...
Alberto Leoni, Alessandro Consorti, Mirella Rambaldi, Alessandra Locatelli, Rita Morigi   +4 more
doaj   +1 more source

DIFFERENT ROUTES FOR THE SYNTHESIS OF BENZALDEHYDE-BASED DIHYDROPYIMIDINONES VIA BIGINELLI REACTION

Jurnal Kimia Riset, 2023
Multicomponent reactions involving three or more reactants are commonly used to prepare dihydropyrimidinone with various bioactivities. This study reports the different routes for the synthesis of benzaldehyde-based dihydropyrimidinone via the Biginelli ...
Yan Alamanda Ilfahmi, Arif Fadlan
doaj   +1 more source

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction [PDF]

, 2020
A facile and highly efficient FeF3-catalyzed method has been developed for the direct synthesis of functionalized dihydropyrimidines from readily available starting materials via Biginelli reaction.
Krishna, Thalishetti, Laxminarayana, Eppakayala, Kalita, Dipak   +2 more
core   +1 more source

Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis

Chemistry – A European Journal, Volume 32, Issue 9, 2 March 2026.
Mechanochemistry offers a sustainable, solvent‐free alternative to traditional synthesis, often enhanced by additives in a process known as additive‐assisted grinding. This review discusses how various additives, including liquids, ionic solids, and advanced materials like ionic liquids and piezoelectric compounds, improve reaction efficiency ...
Johanna Breinsperger, Nika Podlesnik, Francesco Mele, Michael Schnürch   +3 more
wiley   +1 more source