Results 71 to 80 of about 1,953 (199)

Ethyl 4-[5-(methoxymethyl)furan-2-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Molbank, 2017
A one-pot multicomponent reaction has been used to synthesize the title compound, ethyl 4-[5-(methoxymethyl)furan-2-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate by PTSA catalyzed Biginelli reaction.
Hery Suwito, Salma Zulqaida, Kautsar Ul Haq, Alfinda Novi Kristanti, Indriani Indriani   +4 more
doaj   +1 more source

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

ChemMedChem, Volume 20, Issue 18, September 25, 2025.
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş, Jose Miguel Sansano   +7 more
wiley   +1 more source

Unprecedented linear products by a mechanochemically activated Biginelli reaction using lawsone [PDF]

International audienceThe Biginelli reaction, a crucial multicomponent reaction, was investigated involving 2-hydroxy-1,4-naphthoquinone (lawsone), p-substituted benzaldehydes, and ureas. Surprisingly, the classic Biginelli cyclized DHPM was not observed
Carbonnière, Philippe, Vendier, Laure, Bijani, Christian, Robert, Anne, Baltas, Michel, Sotiropoulos, Jean-Marc, Koumpoura, Christina, L   +6 more
core   +1 more source

Post-polymerization modification via the Biginelli reaction to prepare water-soluble polymer adhesives [PDF]

, 2017
A copolymer precursor containing the β-ketoester moiety has been modified through the Biginelli reaction to get several water-soluble adhesives which are comparable to commercial glues.
Zilin Wang, Yuan Zhao, Yongsan Li, Guoqiang Liu, Ying Yu, Xing Wang, Lei Tao, Lei Yang, Yen Wei   +8 more
core   +1 more source

Facts, Presumptions, and Myths on the Solvent-Free and Catalyst-Free Biginelli Reaction. What is Catalysis for? [PDF]

, 2016
The current manuscript describes the role and importance of catalysis and solvent effects for the Biginelli multicomponent reaction. The overwhelming number of new catalysts and conditions recently published for the Biginelli synthesis, including in some
Aline L. de Oliveira (1589941), Heibbe C. B. de Oliveira (1358022), Tatiani B. Lima (1819279), Roberto Y. Souza (1819282), Haline G. O. Alvim (1819276), Fabricio M. Silva (1819285), Brenno A. D. Neto (1589932), Fabio C. Gozzo (104392), Wender A. da Silva (1795975)   +8 more
core   +1 more source

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
wiley   +1 more source

A Green and Efficient Method for the Preparation of 3,4-Dihydropyrimidin-2(1H)-ones Using Quaternary Ammonium-Treated Clay in Water

Journal of Chemistry, 2013
A variety of 3,4-dihydropyrimidin-2(1H)-ones derivatives were synthesized via three-component Biginelli reaction. The quaternary ammonium-treated clay-catalyzed process proved to be simple, efficient, and environmentally friendly.
Soheil Sayyahi, Sedigheh Jahanbakhshi, Zahra Dehghani   +2 more
doaj   +1 more source

Catalysis With Deep Eutectic Solvents: Challenges and Opportunities

ChemCatChem, Volume 17, Issue 11, June 6, 2025.
Deep eutectic solvents (DESs) are emerging as sustainable alternatives in catalysis, offering tunable properties for diverse chemical transformations. This review explores the dual role of DESs as solvents and catalysts, highlighting advancements in organic chemistry, materials science, CO2 fixation, biomass valorization, polymer degradation, and ...
Eduardo Guzmán
wiley   +1 more source

Bi-SO3H Functionalized Ionic Liquid Based on DABCO: New and Efficient Catalyst for Facile Synthesis of Dihydropyrimidinones

Journal of Chemistry, 2013
A simple and efficient method for the one-pot Biginelli condensation reaction of aldehydes, β-dicarbonyl compounds, and urea or thiourea employing [DABCO](SO3H)2Cl2 as a novel ionic liquid catalyst is described.
Firouzeh Nemati, Sara G. Alizadeh
doaj   +1 more source

Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
1‐(2,4‐Dihydroxyphenyl)ethanone functions as a fundamental precursor in the synthesis of dihydropyrimidinone conjugates that incorporate both chromone and triazole moieties. Docking analyses are performed on 15 synthetic compounds. In silico investigations confirm high binding affinity, with docking energies of −10.7 kcal/mol for compound 5a and −10.9 ...
Kumara Swamy Taviti, T. B. Patrudu, Vishnuvardhana Kishore Polisetti, Venkatesh Bhumireddy Chinnachennaiahgari, Satyanarayana Yatam, Naresh Kumar Katari, Rambabu Gundla   +6 more
wiley   +1 more source