Results 61 to 70 of about 1,953 (199)

One‐Pot Morita–Baylis–Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ‐Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation

ChemSusChem, Volume 19, Issue 1, January 2026.
Sustainable one‐pot synthesis of functionalized γ‐hydroxy derivatives in deep eutectic solvents. A green, sequential CC/CX bond‐forming strategy enables diverse γ‐hydroxy derivatives via Morita–Baylis–Hillman and nucleophilic functionalization in ChCl/Gly deep eutectic solvent.
Marina Ramos‐Martín, Ignacio del Río, Joaquín García‐Álvarez, Alejandro Presa Soto   +3 more
wiley   +1 more source

DIFFERENT ROUTES FOR THE SYNTHESIS OF BENZALDEHYDE-BASED DIHYDROPYIMIDINONES VIA BIGINELLI REACTION

Jurnal Kimia Riset, 2023
Multicomponent reactions involving three or more reactants are commonly used to prepare dihydropyrimidinone with various bioactivities. This study reports the different routes for the synthesis of benzaldehyde-based dihydropyrimidinone via the Biginelli ...
Yan Alamanda Ilfahmi, Arif Fadlan
doaj   +1 more source

Design, Structural Characterization, and Fluorescence Behavior of a New Centrosymmetric Dinuclear Cd(II) Complex With 2‐Formylphenoxyacetic Acid and 1,10‐Phenanthroline

Journal of Spectroscopy, Volume 2026, Issue 1, 2026.
A new centrosymmetric dinuclear Cd(II) complex, [Cd2(L)4(Phen)2] (1) (HL = 2‐formylphenoxyacetic acid; Phen = 1,10‐phenanthroline), was synthesized using Cd(NO3)2·4H2O, 2‐formylphenoxyacetic acid, 1,10‐phenanthroline, and NaOH in a CH3CH2OH/H2O mixture (v:v = 3:1).
Tai Xi-Shi, Wang Li-Hua, Saud I. Al-Resayes, Mohammad Azam, Renata Diniz   +4 more
wiley   +1 more source

Diethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and Ethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Molbank, 2012
Diethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine- 3,5-dicarboxylate and ethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate were obtained simultaneously by the Biginelli ...
Alberto Leoni, Alessandro Consorti, Mirella Rambaldi, Alessandra Locatelli, Rita Morigi   +4 more
doaj   +1 more source

DES‐Promoted Synthesis of 3,4‐Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Gobind Kumar, Sahil Mishra, Pule Seboletswe, Nontobeko Gcabashe, Lalitha Gummidi, Neha Manhas, Talent Makhanya, Gaurav Bhargava, Almahi Idris, Md. Shahidul Islam, Parvesh Singh   +10 more
wiley   +1 more source

Antidiabetic Evaluation of New Pyrimidine‐Thiazoline Hybrids Endorsed With Enzyme Kinetic Studies and Computational Analysis

Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.
We demonstrated the application of molecular hybridization in disclosing new pyrimidine‐thiazole molecular hybrids as potential α‐glucosidase and α‐amylase inhibitors and antioxidant agents. The representative compound of the series exhibited 3‐fold more potency than the standard drug acarbose against α‐glucosidase and 2‐fold greater potency than ...
Gobind Kumar, Pule Seboletswe, Neha Manhas, Safiyah Ghumran, Nontobeko Gcabashe, Gaurav Bhargava, Almahi Idris, Md. Shahidul Islam, Parvesh Singh   +8 more
wiley   +1 more source

H2SO4-Silica Catalyzed One-Pot and Efficient Synthesis of Dihydropyrimidinones Under Solvent-Free Conditions

E-Journal of Chemistry, 2011
H2SO4-Silica efficiently catalyzes the three-component condensation reaction of aldehydes, 1,3-dicarbonyl compounds and urea/thiourea under solvent free conditions to afford the corresponding dihydropyrimidinones and thio-derivatives in high yields ...
Seied Ali Pourmousavi, Maryam Hasani
doaj   +1 more source

An Improved Protocol for Biginelli Reaction

Green and Sustainable Chemistry, 2013
[Hmim][Tfa] was used as catalyst for the Biginelli reaction under microwave heating. Low catalyst loading, reduced reaction time and operational simplicity are the main highlights of this protocol. The proposed protocol was found active in the synthesis of 30 different biologically active compounds.
openaire   +2 more sources

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid

E-Journal of Chemistry, 2005
An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described.
Jin Tong-Shou, Zhao Ying, Liu Li-Bin, Li Tong-Shuang   +3 more
doaj   +1 more source