Results 41 to 50 of about 3,427 (216)
Biginelli dihydropyrimidines and their acetylated derivatives as L-/T-type calcium channel blockers: Synthesis, enantioseparation, and molecular modeling studies. [PDF]
Arch Pharm (Weinheim)Biginelli dihydropyrimidines (DHPM) were designed and synthesized (GD1–GD14), and their binding mechanism to L‐(Cav1.2)/T‐(Cav3.2) type calcium channels was illuminated by advanced molecular modeling techniques. Abstract Biginelli dihydropyrimidines (DHPMs) are considered superior over 1,4‐dihydropyridines (DHPs) in terms of both light and metabolic ...
Gündüz MG +8 more
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A Brønsted acid catalysed enantioselective Biginelli reaction [PDF]
Green Chemistry, 2017 A chiral derivative of 1,2-benzenedisulfonimide, namely (−)-4,5-dimethyl-3,6-bis(o-tolyl)-1,2-benzenedisulfonimide is herein proven to be an efficient chiral catalyst in a one pot three-component Biginelli reaction.
BARBERO, Margherita +2 more
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Investigation of efficient synthesis of 1, 8-dioxo-octahydroxanthene derivatives under solvent-free grinding method [PDF]
, 2013 In these studies, we had observed polyaniline (PANI) supported p-toluene sulfonic acid (TsOH) and FeCl3 (PANI- TsOH, PANI-FeCl3) as excellent reusable solid acid catalysts for the synthesis of 1, 8-dioxo-octahydroxanthene derivatives 4(a-g) under solvent-
P. Dutta, P. Sarma, R. Borah
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Molbank, 2019 The Biginelli reaction is an acid-catalyzed, three-component reaction between an aldehyde, a hydrogen methylene active compound, and urea (or its analogue) and constitutes a rapid and easy synthesis of highly functionalized heterocycles.
Itamar Luís Gonçalves +8 more
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Beilstein Journal of Organic Chemistry, 2017 The Biginelli reaction was combined with the Passerini reaction for the first time in a sequential multicomponent tandem reaction approach. After evaluation of all possible linker components and a suitable solvent system, highly functionalized ...
Andreas C. Boukis +2 more
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, 2007 Department of Chemistry, Punjabi University, Patiala-147 002, Punjab, India E-mail: j_sandhu2002@yahoo.com Manuscript received 28 May 2007, revised 17 July 2007, accepted 18 July 2007 Recent advances In Biginelli reaction are summarized including its latest mechanism, developments In building blocks, catalysts variations, optimization/acceleration of ...
Saini, Anil +2 more
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1,3-Dicarbonyl compounds in stereoselective domino and multicomponent reactions
, 2010 International audienceModern organic synthesis focuses on the discovery and the development of stereoselective multiple bond-forming transformations allowing the creation of several covalent bonds in a single operation.
Bonne, Damien +3 more
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One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor [PDF]
, 2013 The Bohlmann–Rahtz pyridine synthesis and the Hantzsch dihydropyridine synthesis can be carried out in a microwave flow reactor or using a conductive heating flow platform for the continuous processing of material. In the Bohlmann–Rahtz reaction, the use
Bagley, Mark C +4 more
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Molecules, 2000 A conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.
Birgit Jauk +2 more
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Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [PDF]
, 2019 The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities.
Alcántara, Andrés R. +2 more
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