Results 41 to 50 of about 971 (170)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Innovating Electrosynthesis From Metal Electrodeposition to Organic Chemistry: Deep Eutectic Solvents as Efficient and Sustainable Media

ChemSusChem, Volume 19, Issue 11, 15 June 2026.
This review analyzes deep eutectic solvents (DESs) as efficient media for both organic and inorganic electrosynthesis. The improvements in terms of synthetic opportunities and sustainability are discussed, by exploring the multiple roles of DESs as solvents, electrolytes, and promoters, enabling effective and selective electrosynthesis under mild and ...
Cristiana Margarita, Stefano Nejrotti, Alejandro Leal‐Duaso, Marta Feroci, Alessandra Sanson, Claudia Barolo, Matteo Bonomo   +6 more
wiley   +1 more source

DIFFERENT ROUTES FOR THE SYNTHESIS OF BENZALDEHYDE-BASED DIHYDROPYIMIDINONES VIA BIGINELLI REACTION

Jurnal Kimia Riset, 2023
Multicomponent reactions involving three or more reactants are commonly used to prepare dihydropyrimidinone with various bioactivities. This study reports the different routes for the synthesis of benzaldehyde-based dihydropyrimidinone via the Biginelli ...
Yan Alamanda Ilfahmi, Arif Fadlan
doaj   +1 more source

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis

Chemistry – A European Journal, Volume 32, Issue 9, 2 March 2026.
Mechanochemistry offers a sustainable, solvent‐free alternative to traditional synthesis, often enhanced by additives in a process known as additive‐assisted grinding. This review discusses how various additives, including liquids, ionic solids, and advanced materials like ionic liquids and piezoelectric compounds, improve reaction efficiency ...
Johanna Breinsperger, Nika Podlesnik, Francesco Mele, Michael Schnürch   +3 more
wiley   +1 more source

Diethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and Ethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Molbank, 2012
Diethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine- 3,5-dicarboxylate and ethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate were obtained simultaneously by the Biginelli ...
Alberto Leoni, Alessandro Consorti, Mirella Rambaldi, Alessandra Locatelli, Rita Morigi   +4 more
doaj   +1 more source

Nitrogen‐Rich, Tröger's Base‐Linked Porous Organic Polymers (POPs) as Heterogeneous Catalysts and Adsorbents of Organic Pollutants From Water

Journal of Applied Polymer Science, Volume 143, Issue 3, January 15, 2026.
Synthesized Tröger's based POPs showed great versatility in heterogeneous catalysis reactions and for pollutant adsorption. ABSTRACT Porous organic polymers are a new class of polymeric materials that combine permanent porosity, high surface area, monomer diversity, and synthetic tunability, making them highly promising candidates for application in ...
Tiago F. Machado, Saúl Vallejos, Artur J. M. Valente, M. Elisa Silva Serra, Dina Murtinho   +4 more
wiley   +1 more source

One‐Pot Morita–Baylis–Hillman/Allylic Substitution in Deep Eutectic Solvents: Access to γ‐Hydroxy Derivatives via Sequential CC and CX (X = P, N, S, B, Si) Bond Formation

ChemSusChem, Volume 19, Issue 1, January 2026.
Sustainable one‐pot synthesis of functionalized γ‐hydroxy derivatives in deep eutectic solvents. A green, sequential CC/CX bond‐forming strategy enables diverse γ‐hydroxy derivatives via Morita–Baylis–Hillman and nucleophilic functionalization in ChCl/Gly deep eutectic solvent.
Marina Ramos‐Martín, Ignacio del Río, Joaquín García‐Álvarez, Alejandro Presa Soto   +3 more
wiley   +1 more source

Design, Structural Characterization, and Fluorescence Behavior of a New Centrosymmetric Dinuclear Cd(II) Complex With 2‐Formylphenoxyacetic Acid and 1,10‐Phenanthroline

Journal of Spectroscopy, Volume 2026, Issue 1, 2026.
A new centrosymmetric dinuclear Cd(II) complex, [Cd2(L)4(Phen)2] (1) (HL = 2‐formylphenoxyacetic acid; Phen = 1,10‐phenanthroline), was synthesized using Cd(NO3)2·4H2O, 2‐formylphenoxyacetic acid, 1,10‐phenanthroline, and NaOH in a CH3CH2OH/H2O mixture (v:v = 3:1).
Tai Xi-Shi, Wang Li-Hua, Saud I. Al-Resayes, Mohammad Azam, Renata Diniz   +4 more
wiley   +1 more source

H2SO4-Silica Catalyzed One-Pot and Efficient Synthesis of Dihydropyrimidinones Under Solvent-Free Conditions

E-Journal of Chemistry, 2011
H2SO4-Silica efficiently catalyzes the three-component condensation reaction of aldehydes, 1,3-dicarbonyl compounds and urea/thiourea under solvent free conditions to afford the corresponding dihydropyrimidinones and thio-derivatives in high yields ...
Seied Ali Pourmousavi, Maryam Hasani
doaj   +1 more source