Results 41 to 50 of about 2,041,750 (198)

Organocatalytic Asymmetric Biginelli-like Reaction Involving Isatin [PDF]

, 2016
The first asymmetric, Brønsted acid catalyzed Biginelli-like reaction of a ketone has been developed, employing N-substituted isatins as carbonyl substrates, and urea and alkyl acetoacetates as further components.
F. Meneghetti, Mattia Stucchi (1493920), Silvani, Alessandra, Giordano Lesma (1493932), M. Stucchi, Stucchi, Mattia, Meneghetti, Fiorella, Giulia Rainoldi (1493917), A. Sacchetti, Fiorella Meneghetti (1493926), Alessandra Silvani (1493923), G. Rainoldi, SACCHETTI, ALESSANDRO, A. Silvani, Lesma, Giordano, Rainoldi, Giulia, G. Lesma, Alessandro Sacchetti (1493929)   +17 more
core   +1 more source

Bis-bromine-1,4-diazabicyclo[2.2.2]octane Complex (DABCO-Br2): An Efficient and Versatile Reagent for Preparation of Dihydropyrimidinones as a New Protocol for the Biginelli Reaction [PDF]

شیمی کاربردی روز, 2011
A simple and efficient method for the one-pot Biginelli condensation reaction of aldehydes, β-dicarbonyl compounds and urea or thiourea employing tetrameric DABCO-bromine as a novel catalyst is described.
Gholam Hossein Mahdavinia, Mohammad Ali Bigdeli, Samaneh Karimi, Fatemeh Koti   +3 more
doaj   +1 more source

Ethyl 6-Methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Molbank, 2019
The Biginelli reaction is an acid-catalyzed, three-component reaction between an aldehyde, a hydrogen methylene active compound, and urea (or its analogue) and constitutes a rapid and easy synthesis of highly functionalized heterocycles.
Itamar Luís Gonçalves, Gabriel Oliveira de Azambuja, Leonardo Davi, Guilherme Arraché Gonçalves, Luciano Porto Kagami, Gustavo Machado das Neves, João Pedro Silveira, Rômulo Faria Santos Canto, Vera Lucia Eifler-Lima   +8 more
doaj   +1 more source

Pivalic acid assisted Biginelli reaction for synthesis of dihydropyrimidinones and dihydrothiopyrimidinones     [PDF]

, 2021
Herein is provided an alternate, simple, multigram scale, efficient route for Biginelli reaction for synthesis of dihydropyrimidinones using urea, ethylacetatoacetate, and benzaldehyde with pivalic ...
Chodankar, Anika Arjun; Department, of Chemistry, St. Xavier’s College, Mapusa, Goa 403 507, India, Anveka, Tushar S; Department, of Chemistry, St. Xavier’s College, Mapusa, Goa 403 507, India, Vaz, Teotone ; Department, of Chemistry, St. Xavier’s College, Mapusa, Goa 403 507, India, Kadam, Hari K; Department, of Chemistry, St. Xavier’s College, Mapusa, Goa 403 507, India, Gaonkar, Saurabh Sudan; Department, of Chemistry, St. Xavier’s College, Mapusa, Goa 403 507, India, Salgaonkar, Lalitprabha N; Department, of Chemistry, St. Xavier’s College, Mapusa, Goa 403 507, India, Mhaldar, Shashank N; Department of Chemistry, Goa University, Taleigao Plateau, Goa 403 206, India, Gawas, Anushri Laxman; Department, of Chemistry, St. Xavier’s College, Mapusa, Goa 403 507, India, Vernekar, Shruti Sagun; Department, of Chemistry, St. Xavier’s College, Mapusa, Goa 403 507, India   +8 more
core   +2 more sources

Synthesis of structurally diverse 3,4-dihydropyrimidin-2(1H)-ones via sequential Biginelli and Passerini reactions

Beilstein Journal of Organic Chemistry, 2017
The Biginelli reaction was combined with the Passerini reaction for the first time in a sequential multicomponent tandem reaction approach. After evaluation of all possible linker components and a suitable solvent system, highly functionalized ...
Andreas C. Boukis, Baptiste Monney, Michael A. R. Meier   +2 more
doaj   +1 more source

Biginelli reaction

, 2007
Department of Chemistry, Punjabi University, Patiala-147 002, Punjab, India E-mail: j_sandhu2002@yahoo.com Manuscript received 28 May 2007, revised 17 July 2007, accepted 18 July 2007 Recent advances In Biginelli reaction are summarized including its latest mechanism, developments In building blocks, catalysts variations, optimization/acceleration of ...
Saini, Anil, Kumar, Sanjay, Sandhu, Jagir S.   +2 more
openaire   +2 more sources

Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients. [PDF]

ChemSusChem
Knoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Chatzigiannis CM, Scalzullo SM, Colacino E, Rivas ME.   +3 more
europepmc   +2 more sources

Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

Molecules, 2000
A conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.
Birgit Jauk, Tetiana Pernat, C. Oliver Kappe   +2 more
doaj   +1 more source

Construction of Isocytosine Scaffolds via DNA-Compatible Biginelli-like Reaction

, 2023
Herein we report a DNA-compatible Biginelli reaction to construct isocytosine scaffolds. This reaction utilizes a one-pot reaction of DNA-conjugated guanidines with aldehydes and methyl cyanoacetates to give isocytosine derivatives, and the method is ...
Yizhou Wu, Liu Liu (512237), Zhaobing Ding (16611702), Yizhou Wu (52735), Liu Liu, Zuozhong Peng (16611705), Zuozhong Peng, Bing Qi, Bing Qi (492962), Zhaobing Ding   +9 more
core   +1 more source

Síntese do monastrol e novos compostos de Biginelli promovida por In(OTf)3 Synthesis of monastrol and of new Biginelli compounds promoted by In(OTf)3

Química Nova, 2005
In this paper, we describe a practical route for the synthesis of Biginelli compounds using In(OTf)3. To study the generality of this catalyst, several examples using aromatic aldehydes, 1,3-dicarbonyl compounds, urea, and thiourea were investigated. The
Marla N. Godoi, Hellen S. Costenaro, Eliane Kramer, Paola S. Machado, Marcelo G. Montes D'Oca, Dennis Russowsky   +5 more
doaj   +1 more source