Results 91 to 100 of about 3,427 (216)

Highly Efficient Synthesis of Substituted 3,4-Dihydropyrimidin-2-(1H)-ones (DHPMs) Catalyzed by Hf(OTf)₄: Mechanistic Insights into Reaction Pathways under Metal Lewis Acid Catalysis and Solvent-Free Conditions

Molecules, 2019
In our studies on the catalytic activity of Group IVB transition metal Lewis acids, Hf(OTf)4 was identified as a highly potent catalyst for „one-pot, three-component„ Biginelli reaction.
Rui Kong, Shuai-Bo Han, Jing-Ying Wei, Xiao-Chong Peng, Zhen-Biao Xie, Shan-Shan Gong, Qi Sun   +6 more
doaj   +1 more source

Solvent free one pot synthesis of novel naphtho[1,8-gh] quinazoline-7,10-dione derivatives with CuCl2

Bulletin of the Chemical Society of Ethiopia, 2018
The Biginelli-type reaction of phenalen-1,3-dione with urea, and benzaldehyde derivatives in the presence of CuCl2 as a catalyst for the synthesis of naphtho[1,8-gh]quinazoline-7,10-diones in solvent free condition are reviewed.
M. K. Mohammadi
doaj   +1 more source

Ferrocén-szubsztituált heterociklusok és származékaik szintézise, szerkezetigazolása és komplex spektroszkópiai vizsgálata = Synthesis, structure determination and complex spectroscopic study of ferrocene-substituted heterocycles and their derivatives [PDF]

, 2007
Új, mono- és poliheterociklusokkal egyszeresen és többszörösen szubsztituált ferrocénszármazékokat állítottunk elő. Szerkezetüket komplex nagyműszeres vizsgálatokkal (IR, MS, röntgendiffrakció, multinukleáris NMR) derítettük fel.
Csámpai, Antal, Perjési, Pál, Sohár, Pál, Túrós, György István, Zsoldosné dr. Mády, Virág   +4 more
core  

Calixarene alpha-ketoacetylenes: versatile platforms for reaction with hydrazine nucleophile [PDF]

, 2018
Late stage diversification of calix[4]arenes and thiacalix[4]arenes with heterocycles remains a significant synthetic challenge and hampers further exploitation of the scaffolds.
Acharya, Bi, Bistri, Boersch, Bromidge, Burilov, Burilov, Cecioni, Chen, Creaven, Credi, Epifanova, Fasting, Gotzinger, Grandjean, Gutsche, Iwamoto, Karpov, Kim, Kumar, Kumar, Lamouchi, Lavendomme, Maher, Muravev, Muravev, Muravev, Muravev, Muravev, Muravev, Ovsyannikov, Rad, Roy, Savithri, Shen, Solovieva, Solovieva, Song, Takahashi, Thiabaud, Vasilevsky, Vicens, Wang, Wang, Wang, Wang, Yang, Yin   +47 more
core   +1 more source

Multicomponent Biginelli's synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by SnCl2.2H2O

Journal of the Brazilian Chemical Society, 2004
The ability of SnCl2.2H2O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described.
Russowsky Dennis, Lopes Fabrício A., Silva Victor S. S. da, Canto Karen F. S., D'Oca Marcelo G. Montes, Godoi Marla N.   +5 more
doaj  

Synthesis of bioactive heterocycles using reusable heterogeneous catalyst HClO4–SiO2 under solvent-free conditions

Green Chemistry Letters and Reviews, 2018
We are reporting a simple, efficient and green protocol for the synthesis of chromenes and dihydropyrimidines (products of Knoevenagel and Biginelli reaction, respectively) by the use of silica-supported perchloric acid (HClO4–SiO2) as an effective ...
Leimajam Vartima Chanu, Thokchom Prasanta Singh, Laishram Ronibala Devi, Okram Mukherjee Singh   +3 more
doaj   +1 more source

Dihydropyrimidine-thiones and clioquinol synergize to target beta-amyloid cellular pathologies through a metal-dependent mechanism [PDF]

, 2017
The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems.
Barrasa, M. Inmaculada, Brown, Lauren E., Caldwell, Guy A., Caldwell, Kim A., Jui, Nathan T., Lindquist, Susan, Schaus, Scott E., Tardiff, Daniel F., Trilles, Richard, Yan, Xiaohui   +9 more
core   +1 more source

Recent Advances in the Application of 2‐Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles

ChemistryOpen, Volume 13, Issue 11, November 2024.
This review highlights recent advances in multicomponent reactions using 2‐aminobenzothiazole as a starting material in the synthesis of diverse heterocycles. These reactions enable the efficient and sustainable construction of novel bioactive molecules and pharmaceuticals.
Ramin Javahershenas, Jianlin Han, Mosstafa Kazemi, Peter J. Jervis   +3 more
wiley   +1 more source

Sustainable Biginelli chemistry: Indian contributions to green multicomponent synthesis

Discover Chemistry
The Biginelli Reaction is a one-pot acid-catalysed cyclo-condensation procedure that combines urea, β-ketoester, and aromatic aldehydes to create functionalised DHPMs. For more than a century, this three-component reaction has been recognised as a method
Rajni, Sahil, Neera Raghav, Anjaneyulu Bendi, G. B. Dharma Rao   +4 more
doaj   +1 more source

Methyl 6-Methyl-1-(4-methylphenyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Molbank, 2012
Methyl 6-methyl-1-(4-methylphenyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate has been synthesized via the modified Biginelli reaction from benzaldehyde, p-tolylurea, and methyl acetoacetate, promoted with microwave irradiation and ...
Haiping Wang, Qing Chen, Qingjian Liu
doaj   +1 more source