O,S,Se-containing Biginelli products based on cyclic β-ketosulfone and their postfunctionalization [PDF]
Beilstein Journal of Organic ChemistryA one-pot three-component Biginelli synthesis of dihydropyrimidinones/thiones/selenones via acetic acid or solvent-free Yb(OTf)3-catalyzed tandem reaction of β-ketosulfone (dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide), an appropriate urea, and ...
Kateryna V. Dil, Vitalii A. Palchykov
doaj +2 more sources
Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications [PDF]
Beilstein Journal of Organic Chemistry, 2011 Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind–Srogl ...
Bruno Piqani, Wei Zhang
doaj +2 more sources
Development of Styryl-Modified 3,4-Dihydropyrimidin-2(1H)-ones as Potential Antitumor Agents. [PDF]
ChemMedChemStyryl‐modified 3,4‐dihydropyrimidin‐2(1H)‐ones (DHPMs), designed from the Eg5 inhibitor monastrol, show markedly enhanced antiproliferative activity in HeLa and MCF‐7 cancer cells. Lead compounds 16 and 17 trigger apoptosis through cell‐line‐specific pathways and downregulate c‐Myc, emerging as promising anticancer candidates.
Panagoulias K +10 more
europepmc +2 more sources
Ultrasound-assisted one-pot synthesis of dihydropyrimid-2-one/thiones catalyzed by zirconyl chloride hexahydrate [PDF]
مجلة التربية والعلم, 2013 Different substituted dihydropyrimidinones and dihydropyrimidin thiones were generated from the Biginelli reaction between aromatic aldehydes, 1,3-dicarbonyl and urea or thiourea under ultrasonic irradiation method.
Omar Yahya, Badie Ahmed, Imad Thanoon
doaj +1 more source
Anticancer Polymers via the Biginelli Reaction [PDF]
ACS Macro Letters, 2020 We developed a polymer-drug strategy to explore anticancer polymers. A series of monomers containing groups with potential anticancer activity have been facilely prepared through the Biginelli reaction. These monomers were used to produce water-soluble polymers through convenient radical copolymerization.
Yongsan Li +6 more
openaire +3 more sources
Double catalytic effect of (PhNH3)2CuCl4 in a novel, highly efficient synthesis of 2-oxo and thioxo-1,2,3,4-tetra-hydopyrimidines [PDF]
Journal of the Serbian Chemical Society, 2015 An innovative route for the construction of 2-oxo and thioxo-1,2,3,4-tetrahydropyrimidines was delineated through a multicomponent reaction under Biginelli conditions, starting from different aromatic aldehydes, β-ketoesters and urea or thiourea.
Janković Nenad +2 more
doaj +1 more source
Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions
Pharmaceuticals, 2022 The interest in 3,4-dihydropyrimidine-2(1H)-(thio)ones is increasing every day, mainly due to their paramount biological relevance. The Biginelli reaction is the classical approach to reaching these scaffolds, although the product diversity suffers from ...
Francisco Sánchez-Sancho +6 more
doaj +1 more source
Highly Enantioselective Organocatalytic Biginelli Reaction [PDF]
Journal of the American Chemical Society, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Xiao-Hua, Chen +4 more
openaire +2 more sources
Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients. [PDF]
ChemSusChemKnoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Chatzigiannis CM +3 more
europepmc +2 more sources
Exploration of the Chemistry and Biological Properties of Pyrimidine as a Privilege Pharmacophore in Therapeutics [PDF]
, 2015 The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin B1.
Ajani, Olayinka O. +3 more
core +4 more sources