Results 171 to 180 of about 1,954,606 (334)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Dynamics-based transition states reveal solvent cage effect and S_N2 transition state motion in Lewis acid catalyzed stereoselective tertiary alcohol nucleophilic substitution reactions. [PDF]

Chem Sci
Schaefer AJ, Mallavia T, Ess DH.
europepmc   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Computational insights into solvent encapsulation and host-guest recognition by calix[4]arene. [PDF]

Sci Rep
Khalil K, Fiser B, Małecka M.
europepmc   +1 more source

THE EXTRACTION OF MORPHINE WITH IMMISCIBLE SOLVENTS. [PDF]

, 1901
W. A. Puckner
openalex   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Investigation of the solubility and thermodynamics of Ivermectin in aqueous mixtures of polyethylene glycols 200/400. [PDF]

BMC Chem
Khezri S, Ghotaslou R, Poturcu K, Soleymani J, Rahimpour E, Jouyban A.   +5 more
europepmc   +1 more source

SYSTEMS FOR THE SEPARATION OF PHOSPHORIC ESTERS BY SOLVENT DISTRIBUTION

, 1950
G. W. E. Plaut, Stephen A. Kuby, Henry A. Lardy   +2 more
openalex   +1 more source

Molecular Polarisations of Nitrobenzene in Various Solvents at 25° C [PDF]

, 1934
H. O. Jenkins
openalex   +1 more source

AN UNUSUAL SOLVENT

British Journal of Anaesthesia, 1977
P. J. Tomlin, John Gjessing
openaire   +3 more sources