Results 171 to 180 of about 10,134,467 (263)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

PVA-Cellulose Fibers Composites Impregnated with Antimicrobial Particles: The Solvent Effect. [PDF]

Polymers (Basel)
Grigoras AG, Popescu I, Gradinaru LM, Mihalache G, Lipsa FD, Nica SL, Grigoras VC.   +6 more
europepmc   +1 more source

Mechanism of an Elusive Solvent Effect in Organozinc Reagent Synthesis. [PDF]

Chemistry, 2020
Hanada EM, Jess K, Blum SA.
europepmc   +1 more source

Solvent Effect on the Structure and Properties of RGD Peptide (1FUV) at Body Temperature (310 K) Using Ab Initio Molecular Dynamics. [PDF]

Polymers (Basel), 2021
Baral K, Adhikari P, Jawad B, Podgornik R, Ching WY.   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Density functional theory insights into the solvent effect on the binding energies of Cd²⁺ in functionalized MOFs. [PDF]

RSC Adv
Hoa VT.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Solvent Effect on the Behavior of Single Eosin Y Photoredox Catalyst. [PDF]

Chem Biomed Imaging
Zhou W, Gu K, Schultz F, Liu C.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Study of Solvent Effect on PVDF-HFP Gel Polymer Electrolyte Containing Ionic Liquid Pyr_1,4TFSI for Lithium Batteries Application. [PDF]

Macromol Rapid Commun
Zanotto PV, Fernandes EG, Martins VL.
europepmc   +1 more source