Results 181 to 190 of about 10,134,467 (263)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Synthesis, photolumescence properties, solvent effect in molecular structure level, topology, and docking studies on Sulfa drug derivative. [PDF]

Sci Rep
Elangovan N, Al-Hussain SA, Kayarohanam S, Wong LS, Gomha SM, Djearamane S, Zaki MEA.   +6 more
europepmc   +1 more source

Chloroquine and hydroxychloroquine inhibitors for COVID-19 sialic acid cellular receptor: Structure, hirshfeld atomic charge analysis and solvent effect. [PDF]

J Mol Struct, 2021
Altalhi TA, Alswat K, Alswat K, Alsanie WF, Ibrahim MM, Aldalbahi A, El-Sheshtawy HS.   +6 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Solvent Effect on Structural Elucidation of Photoluminescent Graphitic Carbon Nanodots. [PDF]

ACS Omega, 2020
Jalilov AS.
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Unveiling the Solvent Effect: DMSO Interaction with Human Nerve Growth Factor and Its Implications for Drug Discovery. [PDF]

Molecules
Paoletti F, Goričan T, Cassetta A, Grdadolnik J, Toporash M, Lamba D, Golič Grdadolnik S, Covaceuszach S.   +7 more
europepmc   +1 more source

Adduct under Field-A Qualitative Approach to Account for Solvent Effect on Hydrogen Bonding. [PDF]

Molecules, 2020
Shenderovich IG, Denisov GS.
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Solvent Effect on Antimicrobial Hydrophilic Xerogel Coating of Medicinal Leathers in Simulated Industrial Finishing Process. [PDF]

Chempluschem
Bompotis T, Karastergiou E, Giannakopoulos K, Favvas EP, Arvanitopoulou M, Arvanitopoulos K, Arvanitopoulos L, Kythreoti G, Vardavoulias M, Giannakoudakis DA, Castellsagués L, Soto González SM, Arkas M.   +12 more
europepmc   +1 more source