Results 21 to 30 of about 19,078 (124)

Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling

Nature Communications, 2022
Tumor loss of IFN-γ signalling is a major mechanism of resistance to immune checkpoint blockers. Here the authors report that melanoma cells with knockout of IFNγR1 show constitutive JAK1/2 activation and that the JAK1/2 inhibitor ruxolitinib can ...
Hongxing Shen, Fengyuan Huang, Xiangmin Zhang, Oluwagbemiga A. Ojo, Yuebin Li, Hoa Quang Trummell, Joshua C. Anderson, John Fiveash, Markus Bredel, Eddy S. Yang, Christopher D. Willey, Zechen Chong, James A. Bonner, Lewis Zhichang Shi   +13 more
doaj   +1 more source

Living roots magnify the response of soil organic carbon decomposition to temperature in temperate grassland

Global Change Biology, Volume 21, Issue 3, Page 1368-1375, March 2015., 2015
Abstract Increasing atmospheric carbon dioxide (CO2) concentration is both a strong driver of primary productivity and widely believed to be the principal cause of recent increases in global temperature. Soils are the largest store of the world's terrestrial C. Consequently, many investigations have attempted to mechanistically understand how microbial
Paul W. Hill, Mark H. Garnett, John Farrar, Zafar Iqbal, Muhammad Khalid, Nawaf Soleman, Davey L. Jones   +6 more
wiley   +1 more source

An Atypical 15q11.2 Microdeletion Not Involving SNORD116 Resulting in Prader–Willi Syndrome

Case Reports in Genetics, 2023
Loss of expression of paternally imprinted genes in the 15q11.2-q13 chromosomal region leads to the neurodevelopmental disorder Prader–Willi Syndrome (PWS).
Molly M. Crenshaw, Sharon L. Graw, Dobromir Slavov, Theresa A. Boyle, Daniel G. Piqué, Matthew Taylor, Peter Baker   +6 more
doaj   +1 more source

Iris Recognition Using Hybrid Self-Organizing Map Classifier and Daugman’s Algorithm

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi), 2023
One of the neural network algorithms that can be used in iris recognition is self-organizing map (SOM). This algorithm has a weakness in determining the initial weight of the network, which is generally carried out randomly, which can result in a ...
Amir Saleh, Yusuf Roni Laia, Fransiskus Gowasa, Victor Daniel Sihombing   +3 more
doaj   +1 more source

Recurrent hyperkalemia in patients with chronic kidney disease and hepatitis C treated with direct antiviral agents

BMC Infectious Diseases, 2019
Background Sofosbuvir is the keystone of direct antiviral agents for the chronic hepatitis C (CHC). The safety of sofosbuvir in patients with stage 4–5 chronic kidney disease (CKD) needs further observation in real world.
Taotao Yan, Jiuping Wang, Juan Li, Shan Fu, Yi Chen, Chunhua Hu, Rou Zhang, Zhen Tian, Fahui Zhao, Jun Dong, Jinfeng Liu, Yuan Yang, Tianyan Chen, Yingren Zhao, Yingli He   +14 more
doaj   +1 more source

siRNA-Mediated β-Catenin Knockdown in Human Hepatoma Cells Results in Decreased Growth and Survival

Neoplasia: An International Journal for Oncology Research, 2007
β-Catenin, the chief oncogenic component of the canonical Wnt pathway, is known to be involved in a variety of cancers, including hepatocellular carcinoma (HCC).
Gang Zeng, Udayan Apte, Benjamin Cieply, Sucha Singh, Satdarshan P.S. Monga   +4 more
doaj   +1 more source

Long-term population trends of bird communities in artificially-protected wetlands of Northern Italy

Avocetta
Artificial wetlands have become a common conservation approach to contrast the decline of biodiversity globally, as a result of the ongoing loss and fragmentation of natural habitats.
Stefano Borghi, Carlo Giannella, Andrea Ravagnani, Rossella Casari, Alessio Farioli, Giuseppe Rossi, Matteo Dal Zotto, Nunzio Grattini, Daniela Campobello   +8 more
doaj   +1 more source

Missing genotype imputation in non‐model species using self‐organizing maps

Molecular Ecology Resources, Volume 25, Issue 3, April 2025.
Abstract Current methodologies of genome‐wide single‐nucleotide polymorphism (SNP) genotyping produce large amounts of missing data that may affect statistical inference and bias the outcome of experiments. Genotype imputation is routinely used in well‐studied species to buffer the impact in downstream analysis, and several algorithms are available to ...
Fernando Mora‐Márquez, Juan Carlos Nuño, Álvaro Soto, Unai López de Heredia   +3 more
wiley   +1 more source

BILLEDET SOM OPLEVELSESFÆNOMEN, SOM AFBILDNING OG SOM SELVSTÆNDIGGJORT GENSTAND

Psyke & Logos, 2022
Temaet i dette nummer af Psyke & Logos hedder Billede og Virkelighed, og der er primært tale om en udvidet præsentation af de foredrag, der blev bragt på Psyke & Logos' åbne konference på KUA i januar, dette år. Pånogle punkter lægger dette tema sig tæt op ad temaet Narrativitet, som vi bragte for et år siden, samtidig er der imidlertid også en
openaire   +1 more source

Coupling Remote Sensing With a Process Model for the Simulation of Rangeland Carbon Dynamics

Journal of Advances in Modeling Earth Systems, Volume 17, Issue 3, March 2025.
Abstract Rangelands provide significant environmental benefits through many ecosystem services, which may include soil organic carbon (SOC) sequestration. However, quantifying SOC stocks and monitoring carbon (C) fluxes in rangelands are challenging due to the considerable spatial and temporal variability tied to rangeland C dynamics as well as limited
Yushu Xia, Jonathan Sanderman, Jennifer D. Watts, Megan B. Machmuller, Andrew L. Mullen, Charlotte Rivard, Arthur Endsley, Haydee Hernandez, John Kimball, Stephanie A. Ewing, Marcy Litvak, Tomer Duman, Praveena Krishnan, Tilden Meyers, Nathaniel A. Brunsell, Binayak Mohanty, Heping Liu, Zhongming Gao, Jiquan Chen, Michael Abraha, Russell L. Scott, Gerald N. Flerchinger, Patrick E. Clark, Paul C. Stoy, Anam M. Khan, E. N. Jack Brookshire, Quan Zhang, David R. Cook, Thomas Thienelt, Bhaskar Mitra, Marguerite Mauritz‐Tozer, Craig E. Tweedie, Margaret S. Torn, Dave Billesbach   +33 more
wiley   +1 more source