Results 31 to 40 of about 41,599 (347)
Annals of the New York Academy of Sciences, 2020 Nerve agents (NAs) produce acute and long‐term brain injury and dysfunction, as evident from the Japan and Syria incidents. Magnetic resonance imaging (MRI) is a versatile technique to examine such chronic anatomical, functional, and neuronal damage in ...
S. Reddy +4 more
semanticscholar +1 more source
Zr(OH)4/GO Nanocomposite for the Degradation of Nerve Agent Soman (GD) in High-Humidity Environments
Materials, 2020 Zirconium hydroxide, Zr(OH)4 is known to be highly effective for the degradation of chemical nerve agents. Due to the strong interaction force between Zr(OH)4 and the adsorbed water, however, Zr(OH)4 rapidly loses its activity for nerve agents under high-
Seongon Jang +5 more
semanticscholar +1 more source
ADMET and Druglikeness Calculations of Sarin, Soman, and Their Hypothetical Derivatives
Iraqi Journal of Industrial Research, 2022 Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) represents a numerical classification of any chemical to be a drug candidate with promising therapeutic efficacy with minimum toxicity or sensitivity depending on its chemical ...
Kafa Khalaf Hammud
doaj +1 more source
Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme [PDF]
, 2010 Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP ...
Andrew C. Hemmert +15 more
core +6 more sources
Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice
Acta Medica, 2018 Aim: The influence of the dose on the ability of promising newly prepared reversible inhibitor of acetylcholinesterase (6-chlorotacrine) to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was ...
Jiří Kassa, Jan Korábečný
doaj +1 more source
Epilepsia Open, 2023 Despite new antiseizure medications, the development of cholinergic‐induced refractory status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to benzodiazepines and other antiseizure medications quickly develops.
Jerome Niquet +3 more
doaj +1 more source
Acta Medica, 1997 1. The changes of cholinesterase activity in rabbit blood, peripheral tissues and the central nervous system following transfusion of erythrocytes with soman inhibited acetylcholinesterase were demonstrated. 2. After incubation with soman for 0.5 or 24 h,
Jiří Kassa, Jiří Bajgar, Josef Fusek
doaj +1 more source
Aging Mechanism of Soman Inhibited Acetylcholinesterase [PDF]
The Journal of Physical Chemistry B, 2012 Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ACh) and terminates synaptic signals. The catalytic serine of AChE can be phosphonylated by soman, one of the most potent nerve agents, and subsequently undergo an aging reaction. This phosphonylation and aging process leads
Gulseher Sarah, Sirin +4 more
openaire +2 more sources
Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]
, 2010 Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
A Timmer +18 more
core +2 more sources
Coding gain in paraunitary analysis/synthesis systems [PDF]
, 1993 A formal proof that bit allocation results hold for the entire class of paraunitary subband coders is presented. The problem of finding an optimal paraunitary subband coder, so as to maximize the coding gain of the system, is discussed.
Soman, Anand K., Vaidyanathan, P. P.
core +1 more source