Results 41 to 50 of about 41,599 (347)

Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes

Journal of Pharmacology and Experimental Therapeutics, 2020
Earlier reports suggested that galantamine, a drug approved to treat mild-to-moderate Alzheimer’s disease (AD), and other centrally acting reversible acetylcholinesterase (AChE) inhibitors can serve as adjunct pretreatments against poisoning by ...
Malcolm Lane, D. Carter, Joseph D Pescrille, Y. Aracava, W. P. Fawcett, G. William Basinger, Edna F. R. Pereira, E. Albuquerque   +7 more
semanticscholar   +1 more source

Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus

Toxics, 2022
Acute exposure to nerve agents induces status epilepticus (SE), which can cause death or long-term brain damage. Diazepam is approved by the FDA for the treatment of nerve agent-induced SE, and midazolam (MDZ) is currently under consideration to replace ...
Taiza H. Figueiredo, Vassiliki Aroniadou-Anderjaska, Volodymyr I. Pidoplichko, James P. Apland, Maria F. M. Braga   +4 more
doaj   +1 more source

Linear phase paraunitary filter banks: theory, factorizations and designs [PDF]

, 1993
M channel maximally decimated filter banks have been used in the past to decompose signals into subbands. The theory of perfect-reconstruction filter banks has also been studied extensively. Nonparaunitary systems with linear phase filters have also been
Nguyen, Truong Q., Soman, Anand K., Vaidyanathan, P. P.   +2 more
core   +2 more sources

The recovery of acetylcholinesterase activity and the progression of neuropathological and pathophysiological alterations in the rat basolateral amygdala after soman-induced status epilepticus: Relation to anxiety-like behavior

Neuropharmacology, 2014
Eric M. Prager, Vassiliki Aroniadou‐Anderjaska, Camila P. Almeida-Suhett, Taíza H. Figueiredo, James P. Apland, Franco Rossetti, Cara Olsen, Maria F. M. Braga   +7 more
openalex   +2 more sources

Midazolam protects B35 neuroblastoma cells through Akt-phosphorylation in reactive oxygen species derived cellular injury [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundSoman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as infection, hemodynamic ...
Won Seog Chong, Chang Lim Hyun, Min Kyu Park, Jeong Min Park, Hyun-Ouk Song, Taejin Park, Young Su Lim, Choon Kyu Cho, Po Soon Kang, Hee Uk Kwon   +9 more
doaj   +1 more source

Refractory and Super-Refractory Status Epilepticus in Nerve Agent-Poisoned Rats Following Application of Standard Clinical Treatment Guidelines

Frontiers in Neuroscience, 2021
Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus (SE). Current guidelines for treatment of NA-induced SE only include prehospital benzodiazepines, which may not fully resolve this life-threatening condition.
Julia E. Morgan, Sara C. Wilson, Benjamin J. Travis, Kathryn H. Bagri, Kathleen T. Pagarigan, Hannah M. Belski, Cecelia Jackson, Kevin M. Bounader, Jessica M. Coppola, Eden N. Hornung, James E. Johnson, Hilary S. McCarren   +11 more
doaj   +1 more source

Development of EM-CCD-based X-ray detector for synchrotron applications [PDF]

, 2014
A high speed, low noise camera system for crystallography and X-ray imaging applications is developed and successfully demonstrated. By coupling an electron-multiplying (EM)-CCD to a 3:1 fibre-optic taper and a CsI(Tl) scintillator, it was possible to ...
A. Warren, A.D. Holland, A.M. Evagora, D.J. Hall, Hall D., Hall D., Hall D., J.H. Tutt, Janesick J., Jerram P., Lutz G., M.R. Soman, Soman M., T. Connolley, Tutt J.   +14 more
core   +1 more source

Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes

Chemical Research in Toxicology, 2015
Zrinka Kovarik, Nikolina Maček Hrvat, Maja Katalinić, Rakesh K. Sit, Alexander Paradyse, Suzana Žunec, Kamil Musílek, Valery V. Fokin, Palmer Taylor, Zoran Radić   +9 more
openalex   +3 more sources

The percutaneous absorption of soman in a damaged skin porcine model and the evaluation of WoundStat™ as a topical decontaminant [PDF]

, 2017
PURPOSE: The aim of this study was to evaluate a candidate haemostat (WoundStat™), down-selected from previous in vitro studies, for efficacy as a potential skin decontaminant against the chemical warfare agent pinacoyl methylfluorophosphonate (Soman, GD)
Chilcott, Robert P, Chipman, J Kevin, Dalton, Christopher, Graham, John S, Hall, Charlotte, Jenner, John, Lydon, Helen   +6 more
core   +2 more sources

The alcoholysis of 1,2,2-trimethylpropyl-methylfluorophosphonate [PDF]

Journal of the Serbian Chemical Society, 2000
The alcoholysis of 1,2,2-trimethylpropyl-methylfluorophosphonate (soman) was examined with a series of alkoxides and in corresponding alcohols: methanol, ethanol, 1-propanol, 2-propanol, 2-methoxyethanol and 2-ethoxyethanol.
Mićević Mlađen L., Petrović Slobodan D.   +1 more
doaj   +3 more sources