Results 91 to 100 of about 830,877 (285)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Genetic parameters for milk somatic cell score and relationships with production traits in primiparous dairy sheep [PDF]

, 2007
A total of 13,066 first-lactation test-day records of 2,277 Valle del Belice ewes from 17 flocks were used to estimate genetic parameters for somatic cell scores (SCS) and milk production traits, using a repeatability test-day animal model.
van Kaam, J. B. C. H. M., Portolano, B., Bovenhuis, H., van Kaam, J.B.C.H.M., Kaam, J.B.C.H.M., van, Finocchiaro, R., BOVENHUIS H., FINOCCHIARO, Raffaella, VAN KAAM JBCHM, Riggio, V.; id_orcid, RIGGIO, Valentina, PORTOLANO, Baldassare, Riggio, V.   +12 more
core   +1 more source

"Iron fetters" of sexual dysfunction: clinical management afoot

Клинический разбор в общей медицине
To date, negative polygenic influence of iron deficiency on reproductive health of female patients, including both general somatic condition deterioration and adverse obstetric and gynecologic outcomes, has been proven.
Mekan R. Orazov, Evgenii D. Dolgov
doaj   +1 more source

Dysfunction in Serotonergic and Noradrenergic Systems and Somatic Symptoms in Psychiatric Disorders

Frontiers in Psychiatry, 2019
Somatic symptoms include a range of physical experiences, such as pain, muscle tension, body shaking, difficulty in breathing, heart palpitation, blushing, fatigue, and sweating.
Yi Liu, Yi Liu, Jingping Zhao, Jingping Zhao, Xiaoduo Fan, Wenbin Guo, Wenbin Guo   +6 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A Study on “Express What One Felt” while Singing: Toward Musical Education that Utilizes Somatic Sensation [PDF]

, 2018
This study investigated somatic sensation and mood before and after singing in order to reveal the changes in these while engaging in musical activity. A questionnaire was used to measure changes in emotions, with “Focusing” techniques applied to measure
HORIUCHI, Utako, ホリウチ, ウタコ, 堀内, 詩子   +2 more
core   +1 more source

Correlation between diminished vagal tone and somatic dysfunction severity in very and extremely low birth weight preterm infants assessed with frequency spectrum heart rate variability and salivary cortisol. [PDF]

Medicine (Baltimore), 2022
Vismara L, Gianmaria Tarantino A, Bergna A, Bianchi G, Bragalini C, Billò E, Dal Farra F, Buffone F, Agosti M.   +8 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

[From acute coronary syndrome to zoster : Differential diagnostics in segmental and somatic dysfunction of the thoracic spine and ribs]. [PDF]

Orthopade, 2022
Schnell H.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source