Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
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The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT CD4+ T cells orchestrate adaptive immunity against respiratory viruses through functionally distinct subsets, yet the qualitative differences between vaccine‐ and infection‐induced responses remain incompletely understood. This review summarizes current evidence on how CD4+ T cell subsets shape the magnitude, breadth, and durability of ...
Masato Kubo
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Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation. [PDF]
Front Immunol, 2021 Sheng Z +8 more
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Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT The presence of anti‐modified protein antibodies (AMPA) is a hallmark of rheumatoid arthritis (RA). AMPA recognize post‐translationally modified proteins and are cross‐reactive. AMPA include anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies (anti‐CarP), and anti‐acetylated protein antibodies (AAPA).
Amber‐Sarai F. L. Stalman +1 more
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Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization. [PDF]
Nucleic Acids Res, 2022 Jeong SL +7 more
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GC B Cells, Tfh Cells, and Influenza bnAbs: Insights for Improving Universal Vaccine Design
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Antibodies are crucial for providing protection against influenza virus infection; however, protective humoral immunity is limited by antigenic drift and shift. Hence, the discovery of broadly neutralizing antibodies (bnAbs) targeting conserved epitopes on hemagglutinin protein evokes the hope of developing a universal influenza vaccine ...
Takeshi Inoue +2 more
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Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity. [PDF]
Front Oncol, 2022 Sofou E +12 more
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The Structure of Vertebrate Antigen Receptor Repertoires: An Evolutionary Perspective
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT In vertebrate adaptive immune systems, somatically diversified antigen receptors assume a central role in self/nonself discrimination. Attesting to the presence of a unique but unknown selective environment at early stages of vertebrate evolution, this facility emerged twice, in the ancestors of jawless and jawed vertebrates.
Thomas Boehm, Orlando B. Giorgetti
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Avidity optimization of a MAGE-A1-specific TCR with somatic hypermutation. [PDF]
Eur J Immunol, 2021 Bassan D +7 more
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Interferon‐Mediated Regulation of Memory B Cell Identity and Function
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Memory B cells are essential for long‐lasting immunity induced by both encountered pathogens and vaccines. Functional diversity within the memory B cell pool is established through interactions between memory B cells and the environment in which they develop and reside.
Alana Kirn, Kim L. Good‐Jacobson
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