TLS as Predictors and Targets in Neoadjuvant Chemoimmunotherapy for NSCLC
Thoracic Cancer, Volume 17, Issue 16, August 2026.TLS in lung cancer adjuvant therapy: (A) cellular composition (T/B cells, DCs); (B) mechanistic pathways (antigen presentation, GC‐like B responses, TRM maintenance); (C) clinical evaluation (IHC, digital pathology, spatial transcriptomics); (D) future directions (dynamic monitoring, intercellular interactions, multicenter trials, clinical translation).
Zhiqi Li +6 more
wiley +1 more source
A somatic hypermutation-based machine learning model stratifies individuals with Crohn's disease and controls. [PDF]
Genome Res, 2023 Safra M +9 more
europepmc +1 more source
Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report
Allergy, Volume 81, Issue 8, Page 2675-2712, August 2026.ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter +19 more
wiley +1 more source
Single-Step IGHV Next-Generation Sequencing Detects Clonality and Somatic Hypermutation in Lymphoid Malignancies: A Phase III Diagnostic Accuracy Study. [PDF]
Cancers (Basel), 2023 Gazzola A +5 more
europepmc +1 more source
Clinical and Experimental Neuroimmunology, Volume 17, Issue 3, August 2026.ABSTRACT Background IgG4‐related disease (IgG4‐RD) is a systemic, immune‐mediated, fibroinflammatory disorder with multiorgan involvement and variable clinical presentation, often creating diagnostic difficulty. Myasthenia gravis (MG) is an antibody‐mediated autoimmune disorder of the neuromuscular junction, most commonly associated with anti ...
Yumiko Yoshida +4 more
wiley +1 more source
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Age‐associated B cells (ABCs) are a distinct B cell population characterized by coexpression of T‐bet and CD11c. First described in aged female mice and autoimmune‐prone strains, ABCs are now recognized to be associated with multiple human autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis,
Kira Rubtsova
wiley +1 more source
The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation. [PDF]
Front Immunol, 2023 Martin OA +13 more
europepmc +1 more source
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Preexisting immunity to influenza confers rapid protection against antigenically matched viruses but can also constrain responses to drifted variants. This review asks when and why prior infection or vaccination is protective versus detrimental, and which biological mechanisms—epitope masking by circulating antibody, inhibitory FcγRIIb ...
Annette Fox +2 more
wiley +1 more source
A novel next-generation sequencing capture-based strategy to report somatic hypermutation status using genomic regions downstream to immunoglobulin rearrangements. [PDF]
Haematologica, 2023 McCafferty N +7 more
europepmc +1 more source
Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley +1 more source