Results 101 to 110 of about 20,554 (213)
Antibodies, 2018 The induction of somatic hypermutation (SHM) in various cell lines by activation-induced cytidine deaminase (AID) has been used in protein-directed selection, especially in antibody affinity maturation.
Chuan Chen +6 more
doaj +1 more source
Brain Pathology, Volume 36, Issue 4, July 2026.This integrated high‐resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34‐mutant expands the spectrum of associated genetic changes and underscores the presence of universal TP53 abnormalities at copy number, sequence, and protein expression level, with frequent yet largely unrecognized TP53 copy‐neutral loss of ...
Jorge A. Trejo‐Lopez +28 more
wiley +1 more source
Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms
, 2011 Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human Genome and the initiation of the HapMap project the concept that the chromosomes of the mammalian genome are
Stewart, B.J. +8 more
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Reflections on the state of play in somatic hypermutation
, 2015 Somatic hypermutation (SHM) of rearranged variable genes proceeds in two phases. Phase I which is well understood is triggered by activation-induced cytidine deaminase (AID) and targets mutations at C:G base pairs equally on both DNA strands.
Steele, Edward J
core +1 more source
Highlights of 2025: advances in germinal centers
Immunology &Cell Biology, Volume 104, Issue 6, Page 609-612, July 2026.Graphical summary of research advances made in 2025 in germinal center (GC) biology. GCB, germinal center B cells; Tfh, T follicular helper cell; APC, antigen‐presenting cell; FDC, follicular dendritic cell; SHM, somatic hypermutation. Created in BioRender. Webb, L. (2026) https://BioRender.com/bn9jx9v.
Louise MC Webb, Michelle A Linterman
wiley +1 more source
Somatic mutation patterns in non-lymphoid cancers resemble the strand biased somatic hypermutation spectra of antibody genes [PDF]
, 2010 It has been long accepted that many types of B cell cancer (lymphomas, myelomas, plasmacytomas, etc.) are derived from the antigen-stimulated B cell Germinal Center (GC) reaction [1], [2], [3] and [4], i.e.
Steele, E.J., Lindley, R.A.
core
Biology Direct, 2006 It has been suggested that codon insertion and/or deletion may represent a mechanism that, along with hypermutation, contributes to the affinity maturation of antibodies.
Zhou Jianhui, Reason Donald C
doaj +1 more source
Transcription-dependent somatic hypermutation occurs at similar levels on functional and nonfunctional rearranged IgH alleles. [PDF]
, 2004 Allelic exclusion of IgH chain expression is stringently established before or during early B cell maturation. It likely relies both on cellular mechanisms, selecting those cells in which a single receptor allows the best possible Ag response, and on ...
Delpy, Laurent +7 more
core +1 more source
Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.
PLoS Biology, 2014 Somatic hypermutation (SH) generates point mutations within rearranged immunoglobulin (Ig) genes of activated B cells, providing genetic diversity for the affinity maturation of antibodies.
Jean-Marie Buerstedde +4 more
doaj +1 more source
PATH-29. CLINICAL SIGNIFICANCE OF TEMOZOLOMIDE-INDUCED SOMATIC HYPERMUTATION IN INITIALLY LOW-GRADE IDH-MUTANT DIFFUSE GLIOMAS [PDF]
, 2018 INTRODUCTION Diffuse low-grade gliomas (DLGG) treated with temozolomide (TMZ) can develop somatic hypermutation. We present data on the incidence and prognostic importance of somatic hypermutation in IDH-mutant DLGGs.
McDermott, Michael +20 more
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