Results 1 to 10 of about 353,099 (204)

Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching [PDF]

Journal of Experimental Medicine, 1998
Immunoglobulin (Ig) heavy chain (HC) class switch recombination (CSR) is a late B cell process that involves intrachromosomal DNA rearrangement.
Rusty Lansford, Klaus Rajewsky, Frederick W Alt   +2 more
exaly   +4 more sources

Low IgE and absence of sensitization in non-T2 asthma: a transcriptomic and cytokine study [PDF]

Frontiers in Immunology
BackgroundAsthma exhibits heterogeneity, including type 2 (T2-high) and non-T2 phenotypes. This study aimed to elucidate the inflammatory mechanisms that drive non-type 2 asthma, a subtype characterized by low immunoglobulin E levels and negative ...
Jyh-Hong Lee, Yu-Tsan Lin, Li-Chieh Wang, Hsin-Hui Yu, Ya-Chiao Hu, Yao-Hsu Yang, Bor-Luen Chiang, Bor-Luen Chiang   +7 more
doaj   +2 more sources

AID/APOBEC–dependent somatic hypermutation and DNA rearrangements of immunoglobulin and non-immunoglobulin genes [PDF]

Annals of Mechnikov's Institute, 2019
Editing Ig genes by activation induced deaminase (AID) initiates the antibody diversification process in B lymphocytes.In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR).The activity of AID is ...
T Kolotova, V Makarenko, L Sorokoumova, M Davidenko   +3 more
doaj   +2 more sources

Genomic features of humoral immunity support tolerance model in Egyptian rousette bats

Cell Reports, 2021
Summary: Bats asymptomatically harbor many viruses that can cause severe human diseases. The Egyptian rousette bat (ERB) is the only known reservoir for Marburgviruses and Sosuga virus, making it an exceptional animal model to study antiviral mechanisms ...
Peter A. Larson, Maggie L. Bartlett, Karla Garcia, Joseph Chitty, Anne Balkema-Buschmann, Jonathan Towner, Jeffrey Kugelman, Gustavo Palacios, Mariano Sanchez-Lockhart   +8 more
doaj   +1 more source

Computational Inference, Validation, and Analysis of 5’UTR-Leader Sequences of Alleles of Immunoglobulin Heavy Chain Variable Genes

Frontiers in Immunology, 2021
Upstream and downstream sequences of immunoglobulin genes may affect the expression of such genes. However, these sequences are rarely studied or characterized in most studies of immunoglobulin repertoires. Inference from large, rearranged immunoglobulin
Yixun Huang, Linnea Thörnqvist, Mats Ohlin   +2 more
doaj   +1 more source

Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch. [PDF]

PLoS ONE, 2017
Previous studies on a limited number of birds suggested that the IgD-encoding gene was absent in birds. However, one of our recent studies showed that the gene was definitely expressed in the ostrich and emu.
Binyue Han, Yan Li, Haitang Han, Yaofeng Zhao, Qingjie Pan, Liming Ren   +5 more
doaj   +1 more source

A preliminary analysis of the immunoglobulin genes in the African elephant (Loxodonta africana). [PDF]

PLoS ONE, 2011
The genomic organization of the IgH (Immunoglobulin heavy chain), Igκ (Immunoglobulin kappa chain), and Igλ (Immunoglobulin lambda chain) loci in the African elephant (Loxodonta africana) was annotated using available genome data.
Yongchen Guo, Yonghua Bao, Hui Wang, Xiaoxiang Hu, Zhihui Zhao, Ning Li, Yaofeng Zhao   +6 more
doaj   +1 more source

AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. [PDF]

PLoS ONE, 2012
Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of
Hillary Selle Gramlich, Tara Reisbig, David G Schatz   +2 more
doaj   +1 more source

Presence of PD-1 similarity genes in monocytes may promote the development of type 1 diabetes mellitus and poor prognosis of pancreatic cancer

BMJ Open Diabetes Research & Care, 2023
Introduction To identify proteins and corresponding genes that share sequential and structural similarity with programmed cell death protein-1 (PD-1) in patients with type 1 diabetes mellitus (T1DM) via bioinformatics analysis.Research design and methods
Wu Zhang, Wenchuan Zhang, Wanfeng Xu, Can Xu, Mingming Zhang, Yuquan Huang, Qingxia Li   +6 more
doaj   +1 more source

Rearrangement of Immunoglobulin Genes in Tumor Cells of Patients with Primary Mediastinal (Thymic) Large B-Cell Lymphoma

Клиническая онкогематология, 2019
Background. Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a malignant tumor with large atypical lymphoid cells expressing post-germinal differentiation markers.
Yana Konstantinovna Mangasarova, Yu. V. Sidorova, A. U. Magomedova, B. V. Biderman, E. E. Nikulina, A. B. Sudarikov, A. M. Kovrigina, S. K. Kravchenko   +7 more
doaj   +1 more source