Results 21 to 30 of about 234,036 (207)

Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases [PDF]

, 2006
Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for ...
Gitit Shahaf, Dunn-Walters, D., Avital Steiman-Shimony, Michal Barak, Roshini S. Abraham, Ramit Mehr, Abraham, Roshini S., Mehr, Ramit, Steiman-Shimony, Avital, Barak, M., Steiman-Shimony, A., David I. Stott, Edelman, H., Edelman, Hanna, Barak, Michal, Stott, David I., Mehr, R., Shahaf, G., Dunn-Walters, Deborah, Deborah Dunn-Walters, Hanna Edelman, Shahaf, Gitit, Abraham, R.S., Stott, D.I.   +23 more
core   +1 more source

Characterization of chicken spleen transcriptome after infection with Salmonella enterica serovar Enteritidis. [PDF]

PLoS ONE, 2012
In this study we were interested in identification of new markers of chicken response to Salmonella Enteritidis infection. To reach this aim, gene expression in the spleens of naive chickens and those intravenously infected with S.
Marta Matulova, Jana Rajova, Lenka Vlasatikova, Jiri Volf, Hana Stepanova, Hana Havlickova, Frantisek Sisak, Ivan Rychlik   +7 more
doaj   +1 more source

Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: chronic activation, normal selection [PDF]

, 2006
Autoimmune diseases show high diversity in the affected organs, clinical manifestations and disease dynamics. Yet they all share common features, such as the ectopic germinal centers found in many affected tissues.
Neta S. Zuckerman, Zuckerman, N.S., Michal Barak, Roshini S. Abraham, Ramit Mehr, Mehr, Ramit, Steiman-Shimony, Avital, David I. Stott, Edelman, H., Hutzler, A., Edelman, Hanna, Zuckerman, Neta S., Stott, David I., Shahaf, G., Deborah Dunn-Walters, Abraham, Roshim S., Shahaf, Gitit, Stott, D.I., Gitit Shahaf, Dunn-Walters, D., Avital Steiman-Shimony, Hutzler, Anat, Barak, M., Steiman-Shimony, A., Barak, Michal, Mehr, R., Dunn-Walters, Deborah, Anat Hutzler, Hanna Edelman, Abraham, R.S.   +29 more
core   +1 more source

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Schwirzke, Marina, Kaluzab, Brigitte, Weissenhorn, Winfried, Weiss, Elisabeth H., Weidle, Ulrich H.   +4 more
core   +1 more source

Target-selective homologous recombination cloning for high-throughput generation of monoclonal antibodies from single plasma cells

BMC Biotechnology, 2011
Background Molecular cloning of functional immunoglobulin genes from single plasma cells is one of the most promising technologies for the rapid development of monoclonal antibody drugs. However, the proper insertion of PCR-amplified immunoglobulin genes
Isobe Masaharu, Yoshioka Megumi, Kurosawa Nobuyuki   +2 more
doaj   +1 more source

Gene expression signatures associated with chronic endometritis revealed by RNA sequencing

Frontiers in Medicine, 2023
IntroductionChronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by the infiltration of plasma cells in the endometrial stroma.
Kyoko Oshina, Kyoko Oshina, Keiji Kuroda, Keiji Kuroda, Kazuhiko Nakabayashi, Junko Tomikawa, Mari Kitade, Rikikazu Sugiyama, Kenichiro Hata, Kenichiro Hata, Atsuo Itakura   +10 more
doaj   +1 more source

Physical map and one-megabase sequencing of the human immunoglobulin lambda locus

Genetics and Molecular Biology, 1998
The human immunoglobulin lambda (IGL) locus is located on chromosome 22q11.1-q11.2 and contains the genes responsible for the immunoglobulin lambda light chains. This locus was recently mapped (physical map) and its 1-Mb DNA totally sequenced.
Geraldo A.S. Passos Jr.
doaj   +1 more source

Expansion of the preimmune antibody repertoire by junctional diversity in Bos taurus. [PDF]

PLoS ONE, 2014
Cattle have a limited range of immunoglobulin genes which are further diversified by antigen independent somatic hypermutation in fetuses. Junctional diversity generated during somatic recombination contributes to antibody diversity but its relative ...
Jenni Liljavirta, Mikael Niku, Tiina Pessa-Morikawa, Anna Ekman, Antti Iivanainen   +4 more
doaj   +1 more source

Fungicidal activity of peptides encoded by immunoglobulin genes

Scientific Reports, 2017
Evidence from previous works disclosed the antimicrobial, antiviral, anti-tumour and/or immunomodulatory activity exerted, through different mechanisms of action, by peptides expressed in the complementarity-determining regions or even in the constant ...
Luciano Polonelli, Tecla Ciociola, Martina Sperindè, Laura Giovati, Tiziana D’Adda, Serena Galati, Luiz R. Travassos, Walter Magliani, Stefania Conti   +8 more
doaj   +1 more source

Poorly Expressed Alleles of Several Human Immunoglobulin Heavy Chain Variable Genes are Common in the Human Population

Frontiers in Immunology, 2021
Extensive diversity has been identified in the human heavy chain immunoglobulin locus, including allelic variation, gene duplication, and insertion/deletion events. Several genes have been suggested to be deleted in many haplotypes.
Mats Ohlin
doaj   +1 more source