Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Educational Items on Immunoglobulin genes.
Lefranc, MP, Huret, JL
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Localization, analysis and evolution of transposed human immunoglobulin VK genes [PDF]
, 1988 The localization of Vκ gene regions to chromosome 2, on which the κ locus is located, and to other chromosomes is described. The Vκ genes that have been transposed to other chromosomes are called orphons.
Klopstock, Thomas +6 more
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Gene conversion in human rearranged immunoglobulin genes [PDF]
, 2006 Over the past 20 years, many DNA sequences have been published suggesting that all or part of the V<sub>H</sub> segment of a rearranged immunoglobulin gene may be replaced in vivo. Two different mechanisms appear to be operating. One of these
Darlow, J.M. +3 more
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The immunoglobulin κ gene families of human and mouse: a cottage industry approach [PDF]
, 2000 Some aspects of the work of our group on the human and mouse immunoglobulin κ genes are reviewed. The human κ locus contains a large duplication: a 600 kb C κ-proximal copy with 40 V κ genes is found in the close vicinity of a 440 kb C κ-distal copy with
Zachau, Hans G.
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Data on haplotype-supported immunoglobulin germline gene inference
Data in Brief, 2017 Data that defines IGHV (immunoglobulin heavy chain variable) germline gene inference using sequences of IgM-encoding transcriptomes obtained by Illumina MiSeq sequencing technology are described.
Ufuk Kirik +3 more
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A comprehensive analysis of immunoglobulin heavy chain genes in the Bactrian camel (Camelus bactrianus) [PDF]
Frontiers of Agricultural Science and Engineering, 2015 Heavy chain only antibodies (HCAbs) represent a rare type of antibody that is devoid of light chains and the CH1 domain that have been reported in cartilaginous fish and camelids.
Zuoxiang LIANG,Tao WANG,Yi SUN,Wenlong YANG,Zhihong LIU,Jing FEI,Ying GUO,Qingwei MA,Qingjie PAN,Liming REN
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The Determinants of B Cell Receptor Signaling as Prototype Molecular Biomarkers of Leukemia
Frontiers in Oncology, 2021 Advanced genome-wide association studies (GWAS) identified several transforming mutations in susceptible loci which are recognized as valuable prognostic markers in chronic lymphocytic leukemia (CLL) and B cell lymphoma (BCL).
Antonella Nicolò +3 more
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VH replacement in rearranged immunoglobulin genes [PDF]
, 2005 Examples suggesting that all or part of the V<sub>H</sub> segment of a rearranged V<sub>H</sub>DJ<sub>H</sub> may be replaced by all or part of another V<sub>H</sub> have been appearing since the 1980s ...
Darlow, J.M. +3 more
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Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4 [PDF]
, 2004 86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
Darlow, J.M. +5 more
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Somatic hypermutation of immunoglobulin and non–immunoglobulin genes [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a highly specific mechanism restricted to B lymphocytes during only a few cell generations. Data presented here suggest that transcription of the target genes is required, but not sufficient for SHM.
U, Storb, H M, Shen, N, Michael, N, Kim
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