Results 31 to 40 of about 234,036 (207)

Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system

Life Science Alliance, 2021
In this study, Scheurer et al demonstrate that two genes encoding the effector domain of immunoglobulins are not only expressed by lymphocytes of the immune system but also by neurons in the central nervous system.
Louis Scheurer, Rebecca R Das Gupta, Annika Saebisch, Thomas Grampp, Dietmar Benke, Hanns Ulrich Zeilhofer, Hendrik Wildner   +6 more
doaj   +1 more source

Organization of Immunoglobulin Genes

Cold Spring Harbor Symposia on Quantitative Biology, 1978
The nucleotide-sequence determination of a cloned, embryonic Vlambda gene directly demonstrated that V genes are separate from a corresponding C gene in embryonic cells. Analysis by restriction enzymes of total cellular DNA from various sources strongly suggested that the two separate immunoglobulin genes become continuous during differentiation of B ...
S, Tonegawa, C, Brack, N, Hozumi, V, Pirrotta   +3 more
openaire   +2 more sources

Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications

Frontiers in Immunology
Poultry immunoglobulin genes undergo diversification through homologous recombination (HR) and somatic hypermutation (SHM). Most animals share a similar system in immunoglobulin diversification, with the rare exception that human and murine ...
Hidetaka Seo, Kouji Hirota, Kunihiro Ohta   +2 more
doaj   +1 more source

Clinical significance of LAIR1 (CD305) as assessed by flow cytometry in a prospective series of patients with chronic lymphocytic leukemia

Haematologica, 2014
Most patients affected by chronic lymphocytic leukemia are diagnosed by flow cytometry. Several immunophenotypic markers have been identified as significant and independent prognostic variables, especially from retrospective cohorts.
Omar Perbellini, Erika Falisi, Ilaria Giaretta, Elisa Boscaro, Elisabetta Novella, Monica Facco, Stefania Fortuna, Silvia Finotto, Eliana Amati, Francesco Maniscalco, Anna Montaldi, Alberta Alghisi, Fiorenza Aprili, Laura Bonaldi, Rossella Paolini, Maria Teresa Scupoli, Livio Trentin, Achille Ambrosetti, Gianpietro Semenzato, Giovanni Pizzolo, Francesco Rodeghiero, Carlo Visco   +21 more
doaj   +1 more source

Carcinoembryonic Antigen Gene Family [PDF]

, 1991
The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons.
Zimmermann, Wolfgang, Grunert, Fritz, Thompson, John A.   +2 more
core   +1 more source

A novel liver-specific immunoglobulin heavy chain-like gene in a cartilaginous fish

Fish and Shellfish Immunology Reports, 2023
We identified a novel immunoglobulin (Ig) heavy chain-like gene (tsIgH) expressed in the liver of the banded houndshark Triakis scyllium by preliminary transcriptomic analysis.
Hidehiro Kondo, Haruka Kamei, Fuyuka Murotani, Reiko Nozaki, Ryosuke Yazawa, Reoto Tani, Keiichiro Koiwai, Ikuo Hirono   +7 more
doaj   +1 more source

Identification of the ancestral killer immunoglobulin-like receptor gene in primates

, 2006
Background: Killer Immunoglobulin-like Receptors (KIR) are essential immuno- surveillance molecules. They are expressed on natural killer and T cells, and interact with human leukocyte antigens.
Penny Coggill, Hanne Andersen, Sambrook Jennifer G, Piatak Mike, Carrington Mary, Jennifer G Sambrook, Coggill, P, Stephan Beck, Carrington, M, Piatak, M, Vernikos George S, Mike Piatak, Vernikos, GS, Bashirova Arman, Beck Stephan, Coggill Penny, Bashirova, A, Lifson, JD, Andersen, H, George S Vernikos, Lifson Jeff D, Beck, S, Jeff D Lifson, Andersen Hanne, Arman Bashirova, Mary Carrington, Sambrook, JG   +26 more
core   +1 more source

Killer cell immunoglobulin-like receptors and their ligands : assessment of potential diagnostic and immunotherapeutic value [PDF]

, 2014
Human natural killer (NK) cells constitute an important arm of the innate immune system, which participates in protection against viral infections and elimination of malignant diseases.
Czaja, Karol Gustaw
core   +1 more source

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

Nature Communications, 2019
Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin ...
Benjamin G. Barwick, Paola Neri, Nizar J. Bahlis, Ajay K. Nooka, Madhav V. Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas A. Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence H. Boise   +13 more
doaj   +1 more source

Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes

Haematologica, 2012
Background Characterization of the immunoglobulin gene repertoire has improved our understanding of the immunopathogenesis of lymphoid tumors. Early B-lymphocyte precursors of multiple myeloma are known to exist and might be susceptible to antigenic ...
Simone Ferrero, Daniela Capello, Mirija Svaldi, Michela Boi, Daniela Gatti, Daniela Drandi, Davide Rossi, Sara Barbiero, Barbara Mantoan, Elisabetta Mantella, Manuela Zanni, Paola Ghione, Alessandra Larocca, Roberto Passera, Francesco Bertoni, Valter Gattei, Francesco Forconi, Luca Laurenti, Giovanni Del Poeta, Roberto Marasca, Sergio Cortelazzo, Gianluca Gaidano, Antonio Palumbo, Mario Boccadoro, Marco Ladetto   +24 more
doaj   +1 more source