Reshaping antibody diversity. [PDF]
Cell, 2013 Some species mount a robust antibody response despite having limited genome-encoded combinatorial diversity potential. Cows are unusual in having exceptionally long CDR H3 loops and few V regions, but the mechanism for creating diversity is not understood.
Wang F +12 more
europepmc +8 more sources
Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish [PDF]
eLife, 2022 Aging individuals exhibit a pervasive decline in adaptive immune function, with important implications for health and lifespan. Previous studies have found a pervasive loss of immune-repertoire diversity in human peripheral blood during aging; however ...
William John Bradshaw +4 more
doaj +2 more sources
Antibody Diversity in Cancer: Translational Implications and Beyond [PDF]
Vaccines, 2022 Patients with cancer tend to develop antibodies to autologous proteins. This phenomenon has been observed across multiple cancer types, including bladder, lung, colon, prostate, and melanoma. These antibodies potentially arise due to induced inflammation
Raghuram Reddy +9 more
doaj +2 more sources
Proteomic profile of the antibody diversity in circulating extracellular vesicles of lung adenocarcinoma [PDF]
Scientific ReportsImmunoglobulin diversity encompasses B-cell receptor, T-cell receptor, and antibody diversity. Existing studies have focused more on the role of B-cell and T-cell receptor diversity in tumor immunity, while the role of antibody diversity is less ...
Xinfu Huang +5 more
doaj +2 more sources
cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence [PDF]
Frontiers in Immunology, 2019 The diversity of B cell receptors provides a basis for recognizing numerous pathogens. Antibody repertoire sequencing has revealed relationships between B cell receptor sequences, their diversity, and their function in infection, vaccination, and disease.
Yicheng Guo +7 more
doaj +2 more sources
Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity [PDF]
Communications BiologyAntibodies, essential components of adaptive immunity, derive their remarkable diversity primarily from V(D)J gene rearrangements, particularly within the heavy chain complementarity-determining region 3 (CDR-H3) where D genes play a major role ...
Ponraj Prabakaran +6 more
doaj +2 more sources
Frontiers in Marine Science, 2023 Elasmobranchs are crucial for comparative studies of evolution, as they belong to the most ancient vertebrate lineages that survived numerous extinction events and persist until today.
Jianqing Wen +14 more
doaj +1 more source
mAbs, 2020 The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire.
Samuel Schmitz +3 more
doaj +1 more source
IL-4Rα Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis. [PDF]
, 2020 Dupilumab is a fully human antibody to interleukin-4 receptor α that improves the signs and symptoms of moderate to severe atopic dermatitis (AD). To determine the effects of dupilumab on Staphylococcus aureus colonization and microbial diversity on the ...
Ardeleanu, Marius +16 more
core +2 more sources
Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens?
Viruses, 2020 Potent antibody-mediated neutralization is critical for an organism to combat the vast array of pathogens it will face during its lifetime. Due to the potential genetic diversity of some viruses, such as HIV-1 and influenza, standard neutralizing ...
Matthew J. Burke +2 more
doaj +1 more source