Results 1 to 10 of about 1,440 (111)
Reshaping Antibody Diversity [PDF]
Cell, 2013 Some species mount a robust antibody response despite having limited genome-encoded combinatorial diversity potential. Cows are unusual in having exceptionally long CDR H3 loops and few V regions, but the mechanism for creating diversity is not understood.
Damian Ekiert +2 more
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Beyond Allotypes: The Influence of Allelic Diversity in Antibody Constant Domains
Frontiers in Immunology, 2020 Polymorphic diversity in antibody constant domains has long been defined by allotypic motifs that cross react with the sera of other individuals. Improvements in sequencing technologies have led to the discovery of a large number of new allelic sequences
Annmaree K. Warrender, William Kelton
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Frontiers in Immunology, 2019 The diversity of B cell receptors provides a basis for recognizing numerous pathogens. Antibody repertoire sequencing has revealed relationships between B cell receptor sequences, their diversity, and their function in infection, vaccination, and disease.
Yicheng Guo +7 more
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Scientific ReportsImmunoglobulin diversity encompasses B-cell receptor, T-cell receptor, and antibody diversity. Existing studies have focused more on the role of B-cell and T-cell receptor diversity in tumor immunity, while the role of antibody diversity is less ...
Xinfu Huang +5 more
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Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens
Frontiers in Immunology, 2022 Allelic diversity of human leukocyte antigen (HLA) class II genes may help maintain humoral immunity against infectious diseases. In this study, we investigated germline genetic variation in classical HLA class II genes and employed a systematic ...
Taushif Khan +7 more
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Antibody Multispecificity Mediated by Conformational Diversity
Science, 2003 A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre–steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing ...
Pietro Roversi +2 more
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Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish
eLife, 2022 Aging individuals exhibit a pervasive decline in adaptive immune function, with important implications for health and lifespan. Previous studies have found a pervasive loss of immune-repertoire diversity in human peripheral blood during aging; however ...
William John Bradshaw +4 more
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Frontiers in Marine Science, 2023 Elasmobranchs are crucial for comparative studies of evolution, as they belong to the most ancient vertebrate lineages that survived numerous extinction events and persist until today.
Jianqing Wen +14 more
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mAbs, 2020 The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire.
Samuel Schmitz +3 more
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Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens?
Viruses, 2020 Potent antibody-mediated neutralization is critical for an organism to combat the vast array of pathogens it will face during its lifetime. Due to the potential genetic diversity of some viruses, such as HIV-1 and influenza, standard neutralizing ...
Matthew J. Burke +2 more
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