Results 31 to 40 of about 394,452 (270)

Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing. [PDF]

PLoS ONE, 2018
Antibody specificity and diversity are generated through the enzymatic splicing of genomic gene segments within each B cell. Antibodies are heterodimers of heavy- and light-chains encoded on separate loci.
Trisha A Rettig, Claire Ward, Bailey A Bye, Michael J Pecaut, Stephen K Chapes   +4 more
doaj   +1 more source

Polymicrobial periodontal disease triggers a wide radius of effect and unique virome. [PDF]

, 2020
Periodontal disease is a microbially-mediated inflammatory disease of tooth-supporting tissues that leads to bone and tissue loss around teeth. Although bacterially-mediated mechanisms of alveolar bone destruction have been widely studied, the effects of
Gao, Li, Ho, Sunita P, Kamarajan, Pachiyappan, Kang, Misun, Kapila, Yvonne L, Kuraji, Ryutaro, Le, Charles, Martinez, April, Rangé, Hélène, Reza Sailani, M, Ye, Changchang, Zhan, Ling, Zhang, Martin Jinye   +12 more
core  

Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola, Ralph Steinman, Richter C. King, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources

BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning

mAbs, 2022
Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic antibody development.
David Prihoda, Jad Maamary, Andrew Waight, Veronica Juan, Laurence Fayadat-Dilman, Daniel Svozil, Danny A. Bitton   +6 more
doaj   +1 more source

V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species

Frontiers in Immunology, 2018
An important characteristic of chickens is that the antibody repertoire is based on a single framework, with diversity found mainly in the CDRs of the light and heavy chain variable regions.
Philip A. Leighton, Jacqueline Morales, William D. Harriman, Kathryn H. Ching   +3 more
doaj   +1 more source

Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires

, 2017
The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in ...
Afzal, Ahmed, Albert, Amanna, Andrews, Angermueller, Apeltsin, Arden, Atchley, Avnir, Barabási, Barak, Bashford-Rogers, Bastian, Baum, Becattini, Ben-Hamo, Berger, Betz, Boc, Bolen, Bolkhovskaya, Bolotin, Bouckaert, Boyd, Boyd, Breden, Brown, Burnet, Bürckert, Calis, Castro, Chang, Chao, Chen, Ching, Cobey, Collins, Corcoran, Covacu, Csardi, Cui, Dash, de Bourcy, DeKosky, DeKosky, DeWitt, Dziubianau, Elhanati, Elhanati, Elhanati, Ellebedy, Emerson, Felsenstein, Friedensohn, Gadala-Maria, Galson, Galson, Geering, Georgiou, Ghraichy, Giribet, Giudicelli, Glanville, Glanville, Glanville, Good, Granato, Greiff, Greiff, Greiff, Greiff, Greiff, Grigaityte, Guindon, Gupta, Gupta, Hagberg, Halliley, Hammarlund, Heather, Hershberg, Hochreiter, Hoehn, Hoehn, Hoehn, Horns, Howie, Iversen, Jackson, Janeway, Jiang, Johnston, Jost, Jurtz, Kaplinsky, Kaplinsky, Kendall, Khavrutskii, Kidd, Kidd, Kidera, Kirik, Konishi, Kumar, Landsverk, Larkin, Lavinder, Laydon, Laydon, Lee, Lee, Lewitus, Li, Lindeman, Lindner, Liu, Love, Lozupone, Madi, Madi, Malissen, Mamoshina, Mangul, Manz, Martin, Meng, Miho, Mora, Morisita, Murugan, Nazarov, Nouri, Oakes, Ostmeyer, Paradis, Parameswaran, Parola, Pinheiro, Pollok, Ralph, Ravn, Reddy, Rempala, Rempala, Revell, Rizzetto, Robinson, Ronquist, Roybal, Rubelt, Rubelt, Safonova, Schliep, Schramm, Schwab, Shannon, Sheng, Sheng, Shlemov, Shugay, Shugay, Shugay, Snir, Snir, Stamatakis, Stern, Strauli, Stubbington, Stubbington, Sun, Sun Cinelli, Swofford, Thomas, Tickotsky, Tonegawa, Torkamani, Trepel, VanDuijn, Venturi, Venturi, Vieira, Vita, Wang, Wardemann, Warren, Watson, Watson, Watson, Weinstein, Wine, Wine, Wu, Yaari, Yaari, Yang, Yeap, Yermanos, Yokota, Yu, Zhu   +200 more
core   +1 more source

Rectal Microbiome Composition Correlates with Humoral Immunity to HIV-1 in Vaccinated Rhesus Macaques. [PDF]

, 2019
The microbiome is an integral and dynamic component of the host and is emerging as a critical determinant of immune responses; however, its influence on vaccine immunogenicity is largely not well understood.
Dinasarapu, Ashok R, Durbin-Johnson, Blythe P, Elizaldi, Sonny R, Iyer, Smita S, Kozlowski, Pamela A, Raeman, Reben, Rolston, Matthew, Settles, Matthew, Verma, Anil, Walter, Korey A   +9 more
core   +1 more source

Insights into next generation sequencing guided antibody selection strategies

Scientific Reports, 2023
Therapeutic antibody discovery often relies on in-vitro display methods to identify lead candidates. Assessing selected output diversity traditionally involves random colony picking and Sanger sequencing, which has limitations. Next-generation sequencing
M. Frank Erasmus, Fortunato Ferrara, Sara D’Angelo, Laura Spector, Camila Leal-Lopes, André A. Teixeira, Jesper Sørensen, Suhani Nagpal, Kathryn Perea-Schmittle, Alok Choudhary, William Honnen, David Calianese, Luis Antonio Rodriguez Carnero, Simon Cocklin, Victor Greiff, Abraham Pinter, Andrew R. M. Bradbury   +16 more
doaj   +1 more source

Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens

Frontiers in Immunology, 2022
Allelic diversity of human leukocyte antigen (HLA) class II genes may help maintain humoral immunity against infectious diseases. In this study, we investigated germline genetic variation in classical HLA class II genes and employed a systematic ...
Taushif Khan, Mahbuba Rahman, Ikhlak Ahmed, Fatima Al Ali, Puthen Veettil Jithesh, Puthen Veettil Jithesh, Nico Marr, Nico Marr   +7 more
doaj   +1 more source

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]

, 2006
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer, A.A. Dandekar, A.D. Luster, B. Mehrad, B. Parra, B. Parra, B.D. Pearce, B.P. Chen, B.T. Fife, C. Gerard, C. Ramakrishna, C. Ramakrishna, C.A. Biron, C.E. Patterson, C.J. Raport, C.M. Hogaboam, D. Franciotta, D. Galimberti, D. Whiting, D.D. Taub, D.J. Mahad, D.M. Muller, D.N. Cook, D.P. Widney, E. Lazzeri, E.J. McMahon, F.R. Fischer, F.S. Cheever, G. Penna, G. Penna, G.B. Huffnagle, G.C. Hildebrandt, G.F. Wu, H. Bartosik-Psujek, H.G. Fischer, H.G. Fischer, I. Banisor, I. Clark-Lewis, I. Salomon, I. Tsunoda, I.E. Flesch, J. Gosling, J.B. Domachowske, J.C. Houck, J.F. Bazan, J.H. Dufour, J.H. Xie, J.J. Phillips, J.M. Farber, J.S. Haring, J.S. Haring, J.S. Williamson, J.S. Williamson, K. Holmes, K. McIntosh, K.E. Balashov, K.S. Held, K.S. Warmington, K.V. Holmes, L. Boring, L. Boring, L. Cartier, L. Gu, L. Gu, L. Pewe, L. Pewe, M. Baggiolini, M. Greter, M. Matsui, M.A. Olszewski, M.J. Buchmeier, M.J. Trifilo, M.J. Trifilo, M.J. Trifilo, M.M. Lai, M.T. Lin, M.T. Lin, M.T. Liu, M.T. Liu, M.T. Liu, N. Sato, N.J. Megjugorac, N.W. Marten, R. Gade-Andavolu, R. Watanabe, R.F. Castro, R.S. Klein, S. Narumi, S. Qin, S. Xue, S.A. Stohlman, S.A. Stohlman, S.D. Miller, S.M. Stamatovic, S.R. Perlman, T.E. Lane, T.E. Lane, T.E. Lane, T.L. Sorensen, T.L. Sorensen, T.S. Kim, T.S. Kim, W.G. Glass, W.G. Glass, W.G. Glass, W.G. Glass, W.J. Karpus, Y. Zhang, Y. Zhou   +108 more
core   +1 more source