Results 21 to 30 of about 1,539 (210)
Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing. [PDF]
PLoS ONE, 2018 Antibody specificity and diversity are generated through the enzymatic splicing of genomic gene segments within each B cell. Antibodies are heterodimers of heavy- and light-chains encoded on separate loci.
Trisha A Rettig +4 more
doaj +1 more source
mAbs, 2022 Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic antibody development.
David Prihoda +6 more
doaj +1 more source
Frontiers in Immunology, 2018 An important characteristic of chickens is that the antibody repertoire is based on a single framework, with diversity found mainly in the CDRs of the light and heavy chain variable regions.
Philip A. Leighton +3 more
doaj +1 more source
Diversity in the Cow Ultralong CDR H3 Antibody Repertoire
Frontiers in Immunology, 2018 Typical antibodies found in humans and mice usually have short CDR H3s and generally flat binding surfaces. However, cows possess a subset of antibodies with ultralong CDR H3s that can range up to 70 amino acids and form a unique “stalk and knob ...
Jeremy K. Haakenson +2 more
doaj +1 more source
Insights into next generation sequencing guided antibody selection strategies
Scientific Reports, 2023 Therapeutic antibody discovery often relies on in-vitro display methods to identify lead candidates. Assessing selected output diversity traditionally involves random colony picking and Sanger sequencing, which has limitations. Next-generation sequencing
M. Frank Erasmus +16 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2023 Background Effective cooperation between B-cells and T-cells within the tumor microenvironment may lead to the regression of established tumors. B-cells and T-cells can recognize tumor antigens with exquisite specificity via their receptor complexes ...
Marco Donia +5 more
doaj +1 more source
Antibody Repertoire: Embracing Diversity
Science Translational Medicine, 2011 Adjuvanted formulations expand the vaccine-induced antibody repertoires against a virus and a parasite.
Pollard, A, Hill, A
openaire +3 more sources
The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature
Pediatric Blood &Cancer, EarlyView.ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi +7 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source