Proteomic profile of the antibody diversity in circulating extracellular vesicles of lung adenocarcinoma [PDF]
Scientific ReportsImmunoglobulin diversity encompasses B-cell receptor, T-cell receptor, and antibody diversity. Existing studies have focused more on the role of B-cell and T-cell receptor diversity in tumor immunity, while the role of antibody diversity is less ...
Xinfu Huang +5 more
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cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence [PDF]
Frontiers in Immunology, 2019 The diversity of B cell receptors provides a basis for recognizing numerous pathogens. Antibody repertoire sequencing has revealed relationships between B cell receptor sequences, their diversity, and their function in infection, vaccination, and disease.
Yicheng Guo +7 more
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Reshaping Antibody Diversity [PDF]
Cell, 2013 Some species mount a robust antibody response despite having limited genome-encoded combinatorial diversity potential. Cows are unusual in having exceptionally long CDR H3 loops and few V regions, but the mechanism for creating diversity is not understood.
Damian C Ekiert +2 more
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Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish [PDF]
eLife, 2022 Aging individuals exhibit a pervasive decline in adaptive immune function, with important implications for health and lifespan. Previous studies have found a pervasive loss of immune-repertoire diversity in human peripheral blood during aging; however ...
William John Bradshaw +4 more
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Antibody Diversity in Cancer: Translational Implications and Beyond [PDF]
Vaccines, 2022 Patients with cancer tend to develop antibodies to autologous proteins. This phenomenon has been observed across multiple cancer types, including bladder, lung, colon, prostate, and melanoma. These antibodies potentially arise due to induced inflammation
Raghuram Reddy +9 more
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Beyond Allotypes: The Influence of Allelic Diversity in Antibody Constant Domains
Frontiers in Immunology, 2020 Polymorphic diversity in antibody constant domains has long been defined by allotypic motifs that cross react with the sera of other individuals. Improvements in sequencing technologies have led to the discovery of a large number of new allelic sequences
Annmaree K. Warrender, William Kelton
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Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity [PDF]
Communications BiologyAntibodies, essential components of adaptive immunity, derive their remarkable diversity primarily from V(D)J gene rearrangements, particularly within the heavy chain complementarity-determining region 3 (CDR-H3) where D genes play a major role ...
Ponraj Prabakaran +6 more
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Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens
Frontiers in Immunology, 2022 Allelic diversity of human leukocyte antigen (HLA) class II genes may help maintain humoral immunity against infectious diseases. In this study, we investigated germline genetic variation in classical HLA class II genes and employed a systematic ...
Taushif Khan +7 more
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Different classes of genomic inserts contribute to human antibody diversity [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Alexey N Davydov +2 more
exaly +2 more sources
Synthetic approach to the generation of antibody diversity [PDF]
BMB Reports, 2015 Hyunbo Shim, Shim Hyunbo
exaly +2 more sources