Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes [PDF]
Frontiers in Immunology, 2016 In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ag) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY
Thiago Detanico +3 more
doaj +2 more sources
A Comparison of Immunoglobulin Variable Region N-Linked Glycosylation in Healthy Donors, Autoimmune Disease and Lymphoma [PDF]
Frontiers in Immunology, 2020 N-linked glycans play an important role in immunity. Although the role of N-linked glycans in the Fragment crystallizable (Fc) region of immunoglobulins has been thoroughly described, the function of N-linked glycans present in Ig-variable domains is ...
Esther M. Vletter +5 more
doaj +2 more sources
Antigen-specific immunoglobulin variable region sequencing measures humoral immune response to vaccination in the equine neonate. [PDF]
PLoS ONE, 2017 The value of prophylactic neonatal vaccination is challenged by the interference of passively transferred maternal antibodies and immune competence at birth.
Rebecca L Tallmadge +3 more
doaj +2 more sources
Peptides That Bind Specifically to an Antibody from a Chronic Lymphocytic Leukemia Clone Expressing Unmutated Immunoglobulin Variable Region Genes [PDF]
Molecular Medicine, 2013 Chronic lymphocytic leukemia (CLL) is a clonal disease of a subset of human B lymphocytes. Although the cause of the disease is unknown, its development and evolution appear to be promoted by signals delivered when B-cell receptors (BCRs) engage (auto ...
Yun Liu +5 more
doaj +2 more sources
Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection. [PDF]
PLoS ONE, 2014 HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (VH ...
Elisabeth Bowers +7 more
doaj +1 more source
, 1973 ALLOTYPE EXPRESSION BY THREE LINKED GENES CODING FOR THE VARIABLE REGION OF RABBIT IMMUNOGLOBULIN HEAVY ...
BYUNG-SUK. KIM (7977689)
core +6 more sources
mAbs, 2020 The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire.
Samuel Schmitz +3 more
doaj +1 more source
The expression of immunoglobulin heavy chain variable region genes in rabbit.
, 1989 The expression of immunoglobulin heavy chain variable region genes in ...
Luisa Ann. DiPietro (7982243)
core +6 more sources
Ig constant region effects on variable region structure and function
Frontiers in Microbiology, 2016 The adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for ...
Alena eJanda +3 more
doaj +1 more source
mAbs, 2021 Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching +7 more
doaj +1 more source