Antigen-specific immunoglobulin variable region sequencing measures humoral immune response to vaccination in the equine neonate. [PDF]
PLoS ONE, 2017 The value of prophylactic neonatal vaccination is challenged by the interference of passively transferred maternal antibodies and immune competence at birth.
Rebecca L Tallmadge +3 more
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A Comparison of Immunoglobulin Variable Region N-Linked Glycosylation in Healthy Donors, Autoimmune Disease and Lymphoma [PDF]
Frontiers in Immunology, 2020 N-linked glycans play an important role in immunity. Although the role of N-linked glycans in the Fragment crystallizable (Fc) region of immunoglobulins has been thoroughly described, the function of N-linked glycans present in Ig-variable domains is ...
Esther M. Vletter +5 more
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Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes [PDF]
Frontiers in Immunology, 2016 In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ag) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY
Thiago Detanico +3 more
doaj +2 more sources
Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection. [PDF]
PLoS ONE, 2014 HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (VH ...
Elisabeth Bowers +7 more
doaj +3 more sources
A genetic marker in the variable region of rabbit immunoglobulin heavy chain [PDF]
Biochemical Journal, 1975 A previous study [Mole et al. (1971) Biochem. J. 124, 301-318] showed several differences in sequence between the variable (V) regions of rabbit immunoglobulin Aa1 and Aa3 heavy chains. The inheritance of one such difference has been followed in a family of 38 rabbits by a radioautographic peptide-‘map’ technique and is shown to segregate in a ...
L R Mole
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Attachment of Carbohydrate to the Variable Region of Myeloma Immunoglobulin Light Chains [PDF]
Proceedings of the National Academy of Sciences, 1970 Approximately 15 per cent of the light chains from homogeneous immunoglobulins in patients with multiple myeloma contain an oligosaccharide group. Five human myeloma light chains that contained carbohydrate were studied. The sequence Asn-[unk]-Ser/Thr was at the site of carbohydrate attachment in all light chains. The carbohydrate group was attached to
Harold C. Sox, Leroy Hood
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Immunoglobulin Variable-Region Structures in Immunity and Autoimmunity to DNA.
The Tohoku Journal of Experimental Medicine, 1994 Important to the immunopathology associated with the autoimmune disease systemic lupus erythematosus, is the production of autoantibody to DNA. Crucial to understanding the immunological basis for autoimmunity to DNA is knowing whether the anti-DNA autoantibody is the product of clonally-selective, antigen-specific B cell stimulation or non-selective ...
Tony N. Marion +5 more
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Peptides That Bind Specifically to an Antibody from a Chronic Lymphocytic Leukemia Clone Expressing Unmutated Immunoglobulin Variable Region Genes [PDF]
Molecular Medicine, 2013 Chronic lymphocytic leukemia (CLL) is a clonal disease of a subset of human B lymphocytes. Although the cause of the disease is unknown, its development and evolution appear to be promoted by signals delivered when B-cell receptors (BCRs) engage (auto ...
Yun Liu +5 more
doaj +2 more sources
TET3 dioxygenase modulates gene conversion at the avian immunoglobulin variable region via demethylation of non-CpG sites in pseudogene templates. [PDF]
Genes Cells, 2021 Takamura N, Seo H, Ohta K.
europepmc +3 more sources
Basic & Clinical Cancer Research, 2017 Chronic lymphocyte leukemia (CLL) is the most common leukemia in elderly individuals that is accompanied by the presence of CD5/CD19/CD20/CD23 positive, FMC7 negative and reduced levels of surface membrane Immunoglobuline (IgM & IgD), CD79b on B ...
Mehrnoosh Pashaei +2 more
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