A Comparison of Immunoglobulin Variable Region N-Linked Glycosylation in Healthy Donors, Autoimmune Disease and Lymphoma [PDF]
Frontiers in Immunology, 2020 N-linked glycans play an important role in immunity. Although the role of N-linked glycans in the Fragment crystallizable (Fc) region of immunoglobulins has been thoroughly described, the function of N-linked glycans present in Ig-variable domains is ...
Esther M. Vletter +5 more
doaj +2 more sources
Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes [PDF]
Frontiers in Immunology, 2016 In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ag) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY
Thiago Detanico +3 more
doaj +2 more sources
Antigen-specific immunoglobulin variable region sequencing measures humoral immune response to vaccination in the equine neonate. [PDF]
PLoS ONE, 2017 The value of prophylactic neonatal vaccination is challenged by the interference of passively transferred maternal antibodies and immune competence at birth.
Rebecca L Tallmadge +3 more
doaj +2 more sources
Peptides That Bind Specifically to an Antibody from a Chronic Lymphocytic Leukemia Clone Expressing Unmutated Immunoglobulin Variable Region Genes [PDF]
Molecular Medicine, 2013 Chronic lymphocytic leukemia (CLL) is a clonal disease of a subset of human B lymphocytes. Although the cause of the disease is unknown, its development and evolution appear to be promoted by signals delivered when B-cell receptors (BCRs) engage (auto ...
Yun Liu +5 more
doaj +2 more sources
Activation and Tolerance in CD4+ T Cells Reactive to an Immunoglobulin Variable Region [PDF]
Journal of Experimental Medicine, 2004 Antibody diversity creates an immunoregulatory challenge for T cells that must cooperate with B cells, yet discriminate between self and nonself. To examine the consequences of T cell reactions to the B cell receptor (BCR), we generated a transgenic (Tg) line of mice expressing a T cell receptor (TCR) specific for a κ variable region peptide in ...
Christopher M Snyder +2 more
exaly +3 more sources
Immunoglobulin heavy chain variable region analysis in dairy goats
Immunobiology, 2018 Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is present on seven genome scaffolds, and contains ten VH, three DH and six JH segments. After the exclusion of three shorter segments, the VH genes were divided into two gene families based on ...
Haidong Zhao, Qingwang Li, Xiuzhu Sun
exaly +3 more sources
Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection. [PDF]
PLoS ONE, 2014 HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (VH ...
Elisabeth Bowers +7 more
doaj +1 more source
mAbs, 2020 The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire.
Samuel Schmitz +3 more
doaj +1 more source
Controlling somatic hypermutation in immunoglobulin variable and switch regions [PDF]
Immunologic Research, 2010 Activation-induced deaminase (AID) is a B-cell-specific enzyme required for initiating the mechanisms of affinity maturation and isotype switching of antibodies. AID functions by deaminating cytosine to uracil in DNA, which initiates a cascade of events resulting in mutations and strand breaks in the immunoglobulin loci. There is an intricate interplay
Robert W, Maul, Patricia J, Gearhart
openaire +2 more sources
mAbs, 2021 Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching +7 more
doaj +1 more source