Results 1 to 10 of about 89,713 (116)
A Comparison of Immunoglobulin Variable Region N-Linked Glycosylation in Healthy Donors, Autoimmune Disease and Lymphoma [PDF]
Frontiers in Immunology, 2020 N-linked glycans play an important role in immunity. Although the role of N-linked glycans in the Fragment crystallizable (Fc) region of immunoglobulins has been thoroughly described, the function of N-linked glycans present in Ig-variable domains is ...
Esther M. Vletter +5 more
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Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes [PDF]
Frontiers in Immunology, 2016 In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ag) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY
Thiago Detanico +3 more
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Antigen-specific immunoglobulin variable region sequencing measures humoral immune response to vaccination in the equine neonate. [PDF]
PLoS ONE, 2017 The value of prophylactic neonatal vaccination is challenged by the interference of passively transferred maternal antibodies and immune competence at birth.
Rebecca L Tallmadge +3 more
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Peptides That Bind Specifically to an Antibody from a Chronic Lymphocytic Leukemia Clone Expressing Unmutated Immunoglobulin Variable Region Genes [PDF]
Molecular Medicine, 2013 Chronic lymphocytic leukemia (CLL) is a clonal disease of a subset of human B lymphocytes. Although the cause of the disease is unknown, its development and evolution appear to be promoted by signals delivered when B-cell receptors (BCRs) engage (auto ...
Yun Liu +5 more
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Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection. [PDF]
PLoS ONE, 2014 HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (VH ...
Elisabeth Bowers +7 more
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mAbs, 2020 The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire.
Samuel Schmitz +3 more
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mAbs, 2021 Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching +7 more
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Ig constant region effects on variable region structure and function
Frontiers in Microbiology, 2016 The adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for ...
Alena eJanda +3 more
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Communications Biology, 2021 Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme.
Maxime Lecerf +3 more
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Frontiers in Immunology, 2021 Vast repertoires of unique antigen receptors are created in developing B and T lymphocytes. The antigen receptor loci contain many variable (V), diversity (D) and joining (J) gene segments that are arrayed across very large genomic expanses and are ...
Amy L. Kenter +2 more
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