Results 41 to 50 of about 89,290 (305)

Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

Haematologica, 2014
In chronic lymphocytic leukemia, usually a monoclonal disease, multiple productive immunoglobulin heavy chain gene rearrangements are identified sporadically. Prognostication of such cases based on immunoglobulin heavy variable gene mutational status can
Karla Plevova, Hana Skuhrova Francova, Katerina Burckova, Yvona Brychtova, Michael Doubek, Sarka Pavlova, Jitka Malcikova, Jiri Mayer, Boris Tichy, Sarka Pospisilova   +9 more
doaj   +1 more source

Immunoglobulin Variable-Region Structures in Immunity and Autoimmunity to DNA.

The Tohoku Journal of Experimental Medicine, 1994
Important to the immunopathology associated with the autoimmune disease systemic lupus erythematosus, is the production of autoantibody to DNA. Crucial to understanding the immunological basis for autoimmunity to DNA is knowing whether the anti-DNA autoantibody is the product of clonally-selective, antigen-specific B cell stimulation or non-selective ...
MARION, TONY N., TILLMAN, DAVID M., KRISHNAN, MEERA K., DESAI, DHARMESH D., JOU, NAINN-TSYR, RUFF, MICHAEL B.   +5 more
openaire   +3 more sources

98% IGHV gene identity is the optimal cutoff to dichotomize the prognosis of Chinese patients with chronic lymphocytic leukemia

Cancer Medicine, 2020
Immunoglobulin heavy chain variable region (IGHV) mutational status has been an important prognostic factor for chronic lymphocytic leukemia (CLL) for decades.
Ke Shi, Qian Sun, Chun Qiao, Huayuan Zhu, Li Wang, Jiazhu Wu, Lili Wang, Jianxin Fu, Ken H. Young, Lei Fan, Yi Xia, Wei Xu, Jianyong Li   +12 more
doaj   +1 more source

HIV gp120 Induces the Release of Proinflammatory, Angiogenic, and Lymphangiogenic Factors from Human Lung Mast Cells

Vaccines, 2020
Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are involved in chronic pulmonary diseases occurring at high frequency among HIV-infected individuals.
Giancarlo Marone, Francesca Wanda Rossi, Antonio Pecoraro, Valentina Pucino, Gjada Criscuolo, Amato de Paulis, Giuseppe Spadaro, Gianni Marone, Gilda Varricchi   +8 more
doaj   +1 more source

Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions

mAbs, 2021
Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This work
Pin-Kuang Lai, Gaurav Ghag, Yao Yu, Veronica Juan, Laurence Fayadat-Dilman, Bernhardt L. Trout   +5 more
doaj   +1 more source

Preferential use of unmutated immunoglobulin heavy variable region genes in Boxer dogs with chronic lymphocytic leukemia.

PLoS ONE, 2018
Human chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, and immunoglobulin heavy variable region (IGHV) gene mutational status is an important prognostic marker.
Emily D Rout, Robert C Burnett, Julia D Labadie, Janna A Yoshimoto, Anne C Avery   +4 more
doaj   +1 more source

Attachment of Carbohydrate to the Variable Region of Myeloma Immunoglobulin Light Chains [PDF]

Proceedings of the National Academy of Sciences, 1970
Approximately 15 per cent of the light chains from homogeneous immunoglobulins in patients with multiple myeloma contain an oligosaccharide group. Five human myeloma light chains that contained carbohydrate were studied. The sequence Asn-[unk]-Ser/Thr was at the site of carbohydrate attachment in all light chains. The carbohydrate group was attached to
H C, Sox, L, Hood
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The V_H gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus [PDF]

, 2003
In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high ...
Stott, DI, Gary Rowley, Fraser, N.L.W., Field, M, Fraser, NLW, Rowley, G., Field, M., Max Field, Rowley, G, David I Stott, Stott, D.I., Nicola LW Fraser   +11 more
core   +1 more source

Comprehensive analysis of immunoglobulin expression in the mouse brain from embryonic to adult stages

Journal of Neuroinflammation
Immunoglobulin (Ig) is a critical molecule in the body’s defense against foreign substances such as bacteria and viruses. While traditionally considered B cell specific, studies have reported that Ig is also expressed by non-B cells.
Keiko Morimoto, Hitomi Sano, Michiko Takahashi, Rikuo Takahashi, Kazunori Nakajima   +4 more
doaj   +1 more source