Results 51 to 60 of about 163,653 (347)

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]

, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris, Cascio, Duilio, Eisenberg, David S, Esswein, Shannon R, Ly, Alan T, Phillips, Martin L, Salwinski, Lukasz, Sawaya, Michael R   +7 more
core   +1 more source

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design [PDF]

, 2017
Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but ...
Angal, Bole, Borth, Breedveld, Chloe L. Stoyle, David P. Humphreys, Du, Durocher, Ellgaard, Feige, Feige, Freeze, Heath, Hendershot, Hendershot, Hu, Hubbard, Iwamoto, Katharine Cain, Leitzgen, Mains, Mason, Minegishi, Neil J. Bulleid, Nguyen, Paul E. Stephens, Peters, Sam Heywood, Schellenberger, Slanina, Spiess, Thies, Werther, Yang, Zou   +34 more
core   +1 more source

Sequence analysis of variable regions of human monoclonal anti-P immunoglobulin

Zhongguo shuxue zazhi
[Objective] To identify the structure of the complementarity determining region (CDRs), the V(D)J rearrangement and somatic hypermutational characteristics of the heavy and light chains of a red blood cell blood group-specific monoclonal antibody ...
GUO Zhonghui, XIANG Dong, LI Qin, ZHU Ziyan   +3 more
doaj   +1 more source

Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution [PDF]

, 2015
Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA ...
Bertram, JG, Chaurasiya, KR, Goodman, MF, Jaszczur, M, Mak, CH, Pham, P, Rueda, DS, Senavirathne, G   +7 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Comprehensive analysis of immunoglobulin expression in the mouse brain from embryonic to adult stages

Journal of Neuroinflammation
Immunoglobulin (Ig) is a critical molecule in the body’s defense against foreign substances such as bacteria and viruses. While traditionally considered B cell specific, studies have reported that Ig is also expressed by non-B cells.
Keiko Morimoto, Hitomi Sano, Michiko Takahashi, Rikuo Takahashi, Kazunori Nakajima   +4 more
doaj   +1 more source

Diversity and structure of human T-Cell receptor β-chain variable region genes [PDF]

, 1986
The nucleotide sequences of 27 T-cell receptor β cDNA clones isolated from a human peripheral lymphocyte library were determined and compared to five additional published sequences. These cDNA clones represent 22 distinct T-cell receptor β-chain variable
Concannon, Patrick, Hood, Leroy, Kung, Patrick, Pickering, Lulu A.   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

Haematologica, 2014
A number of single nucleotide polymorphisms have been associated with disease predisposition in chronic lymphocytic leukemia. A single nucleotide polymorphism in the MDM2 promotor region, MDM2SNP309, was shown to soothe the p53 pathway.
Axel Benner, Larry Mansouri, Davide Rossi, Aneela Majid, Kerstin Willander, Anton Parker, Gareth Bond, Sarka Pavlova, Holger Nückel, Olaf Merkel, Paolo Ghia, Emili Montserrat, Mohd Arifin Kaderi, Richard Rosenquist, Gianluca Gaidano, Martin J.S. Dyer, Peter Söderkvist, Mats Linderholm, David Oscier, Zuzana Tvaruzkova, Sarka Pospisilova, Ulrich Dührsen, Richard Greil, Hartmut Döhner, Stephan Stilgenbauer, Thorsten Zenz   +25 more
doaj   +1 more source

Reprogramming the Constant Region of Immunoglobulin G Subclasses for Enhanced Therapeutic Potency against Cancer

Biomolecules, 2020
The constant region of immunoglobulin (Ig) G antibodies is responsible for their effector immune mechanism and prolongs serum half-life, while the fragment variable (Fv) region is responsible for cellular or tissue targeting.
Tae Hyun Kang, Sang Taek Jung
doaj   +1 more source