Results 31 to 40 of about 89,290 (305)

Gene conversion in human rearranged immunoglobulin genes [PDF]

, 2006
Over the past 20 years, many DNA sequences have been published suggesting that all or part of the V_H segment of a rearranged immunoglobulin gene may be replaced in vivo. Two different mechanisms appear to be operating. One of these
Darlow, J.M., John M. Darlow, David I. Stott, Stott, D.I.   +3 more
core   +1 more source

A novel liver-specific immunoglobulin heavy chain-like gene in a cartilaginous fish

Fish and Shellfish Immunology Reports, 2023
We identified a novel immunoglobulin (Ig) heavy chain-like gene (tsIgH) expressed in the liver of the banded houndshark Triakis scyllium by preliminary transcriptomic analysis.
Hidehiro Kondo, Haruka Kamei, Fuyuka Murotani, Reiko Nozaki, Ryosuke Yazawa, Reoto Tani, Keiichiro Koiwai, Ikuo Hirono   +7 more
doaj   +1 more source

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E., Heufelder, Armin E., Scriba, Peter C.   +2 more
core   +1 more source

Tumor-Associated Disialylated Glycosphingolipid Antigen-Revealing Antibodies Found in Melanoma Patients' Immunoglobulin Repertoire Suggest a Two-Direction Regulation Mechanism Between Immune B Cells and the Tumor

Frontiers in Immunology, 2019
There is far less information available about the tumor infiltrating B (TIL-B) cells, than about the tumor infiltrating T cells. We focused on discovering the features and potential role of B lymphocytes in solid tumors.
Beatrix Kotlan, Szabolcs Horvath, Klara Eles, Vanda K. Plotar, Gyorgy Naszados, Katalin Czirbesz, Miri Blank, Emil Farkas, Laszlo Toth, Jozsef Tovari, Andras Szekacs, Yehuda Shoenfeld, Maria Godeny, Miklos Kasler, Miklos Kasler, Gabriella Liszkay   +15 more
doaj   +1 more source

Data on the nucleotide composition of the first codons encoding the complementary determining region 3 (CDR3) in immunoglobulin heavy chains

Data in Brief, 2018
The highly variable complementary determining region 3 (CDR3) of antibodies is generated through recombination of immunoglobulin heavy chain variable (IGHV), diversity, and joining genes.
Linnea Thörnqvist, Mats Ohlin
doaj   +1 more source

Big domains are novel Ca²+-binding modules: evidences from big domains of Leptospira immunoglobulin-like (Lig) proteins. [PDF]

PLoS ONE, 2010
BackgroundMany bacterial surface exposed proteins mediate the host-pathogen interaction more effectively in the presence of Ca²+. Leptospiral immunoglobulin-like (Lig) proteins, LigA and LigB, are surface exposed proteins containing Bacterial ...
Rajeev Raman, V Rajanikanth, Raghavan U M Palaniappan, Yi-Pin Lin, Hongxuan He, Sean P McDonough, Yogendra Sharma, Yung-Fu Chang   +7 more
doaj   +1 more source

Immunodeficiency, Centromeric Region Instability, and Facial Anomalies Syndrome (ICF) in a Boy with Variable Clinical and Immunological Presentations

Iranian Journal of Allergy, Asthma and Immunology, 2021
Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare primary immunodeficiency disorder characterized by recurrent infections and low immunoglobulin levels due to variable combined immunodeficiency, and centromeric ...
Mohammad Hassan Bemanian, Saba Arshi, Mohammad Nabavi, Mohammad Vafaee-Shahi, Morteza Fallahpour, Sima Shokri, Afshin Rezaeifar, Hossein Shahzadi, Fatemeh Atashrazm   +8 more
doaj   +1 more source

VH-RELATED IDIOTOPES DETECTED BY SITE-DIRECTED MUTAGENESIS [PDF]

, 1992
The function of the CD4 cell surface protein as coreceptor on T helper lymphocytes and as receptor for HIV makes this glycoprotein a prime target for an immune intervention with mAb.
Rieber, Ernst Peter, Weissenhorn, Winfried, Weiss, Elisabeth H., Cheng, Y. H., Riethmüller, Gert   +4 more
core   +1 more source

A genome-wide association study for allergen component sensitizations identifies allergen component–specific and allergen protein group–specific associations

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases.
Wataru Morii, PhD, Koki Kasai, BS, Takako Nakamura, MSc, Daisuke Hayashi, MD, Monami Hara, MD, Tatsuhiko Naito, MD, PhD, Kyuto Sonehara, MD, PhD, Tatsuki Fukuie, MD, PhD, Mayako Saito-Abe, MD, PhD, Limin Yang, MD, PhD, Kiwako Yamamoto-Hanada, MD, PhD, Masami Narita, MD, PhD, Kazushi Maruo, PhD, Yukinori Okada, MD, PhD, Emiko Noguchi, MD, PhD, Yukihiro Ohya, MD, PhD   +15 more
doaj   +1 more source

Genomic Organization, Splice Variants and Expression of CGMl, a CD66-related Member of the Carcinoembryonic Antigen Gene Family [PDF]

, 1993
The tumor marker carcinoembryonic antigen (CEA) belongs to a family of proteins which are composed of one immunogiobulin variable domain and a varying number of immunoglobulin constant-like domains.
Zimmermann, Wolfgang, Grunert, F., Suzanne M. WATT, Watt, S. M., Grunert, Fritz, Watt, Suzanne M., Thompson, J., Fritz GRUNERT, Kuijpers, Taco W., John THOMPSON, Nagel, Gerhard, Thompson, John A., Kuijpers, T. W., Taco W. KUIJPERS, Gerhard NAGEL, Wolfgang ZIMMERMANN, Zimmermann, W., Nagel, G.   +17 more
core   +1 more source