Results 21 to 30 of about 89,812 (215)

Immunodeficiency, Centromeric Region Instability, and Facial Anomalies Syndrome (ICF) in a Boy with Variable Clinical and Immunological Presentations

Iranian Journal of Allergy, Asthma and Immunology, 2021
Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare primary immunodeficiency disorder characterized by recurrent infections and low immunoglobulin levels due to variable combined immunodeficiency, and centromeric ...
Mohammad Hassan Bemanian, Saba Arshi, Mohammad Nabavi, Mohammad Vafaee-Shahi, Morteza Fallahpour, Sima Shokri, Afshin Rezaeifar, Hossein Shahzadi, Fatemeh Atashrazm   +8 more
doaj   +1 more source

A genome-wide association study for allergen component sensitizations identifies allergen component–specific and allergen protein group–specific associations

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases.
Wataru Morii, PhD, Koki Kasai, BS, Takako Nakamura, MSc, Daisuke Hayashi, MD, Monami Hara, MD, Tatsuhiko Naito, MD, PhD, Kyuto Sonehara, MD, PhD, Tatsuki Fukuie, MD, PhD, Mayako Saito-Abe, MD, PhD, Limin Yang, MD, PhD, Kiwako Yamamoto-Hanada, MD, PhD, Masami Narita, MD, PhD, Kazushi Maruo, PhD, Yukinori Okada, MD, PhD, Emiko Noguchi, MD, PhD, Yukihiro Ohya, MD, PhD   +15 more
doaj   +1 more source

Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

Haematologica, 2014
In chronic lymphocytic leukemia, usually a monoclonal disease, multiple productive immunoglobulin heavy chain gene rearrangements are identified sporadically. Prognostication of such cases based on immunoglobulin heavy variable gene mutational status can
Karla Plevova, Hana Skuhrova Francova, Katerina Burckova, Yvona Brychtova, Michael Doubek, Sarka Pavlova, Jitka Malcikova, Jiri Mayer, Boris Tichy, Sarka Pospisilova   +9 more
doaj   +1 more source

98% IGHV gene identity is the optimal cutoff to dichotomize the prognosis of Chinese patients with chronic lymphocytic leukemia

Cancer Medicine, 2020
Immunoglobulin heavy chain variable region (IGHV) mutational status has been an important prognostic factor for chronic lymphocytic leukemia (CLL) for decades.
Ke Shi, Qian Sun, Chun Qiao, Huayuan Zhu, Li Wang, Jiazhu Wu, Lili Wang, Jianxin Fu, Ken H. Young, Lei Fan, Yi Xia, Wei Xu, Jianyong Li   +12 more
doaj   +1 more source

HIV gp120 Induces the Release of Proinflammatory, Angiogenic, and Lymphangiogenic Factors from Human Lung Mast Cells

Vaccines, 2020
Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are involved in chronic pulmonary diseases occurring at high frequency among HIV-infected individuals.
Giancarlo Marone, Francesca Wanda Rossi, Antonio Pecoraro, Valentina Pucino, Gjada Criscuolo, Amato de Paulis, Giuseppe Spadaro, Gianni Marone, Gilda Varricchi   +8 more
doaj   +1 more source

Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions

mAbs, 2021
Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This work
Pin-Kuang Lai, Gaurav Ghag, Yao Yu, Veronica Juan, Laurence Fayadat-Dilman, Bernhardt L. Trout   +5 more
doaj   +1 more source

Preferential use of unmutated immunoglobulin heavy variable region genes in Boxer dogs with chronic lymphocytic leukemia.

PLoS ONE, 2018
Human chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, and immunoglobulin heavy variable region (IGHV) gene mutational status is an important prognostic marker.
Emily D Rout, Robert C Burnett, Julia D Labadie, Janna A Yoshimoto, Anne C Avery   +4 more
doaj   +1 more source

Sequence analysis of variable regions of human monoclonal anti-P immunoglobulin

Zhongguo shuxue zazhi
[Objective] To identify the structure of the complementarity determining region (CDRs), the V(D)J rearrangement and somatic hypermutational characteristics of the heavy and light chains of a red blood cell blood group-specific monoclonal antibody ...
GUO Zhonghui, XIANG Dong, LI Qin, ZHU Ziyan   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Comprehensive analysis of immunoglobulin expression in the mouse brain from embryonic to adult stages

Journal of Neuroinflammation
Immunoglobulin (Ig) is a critical molecule in the body’s defense against foreign substances such as bacteria and viruses. While traditionally considered B cell specific, studies have reported that Ig is also expressed by non-B cells.
Keiko Morimoto, Hitomi Sano, Michiko Takahashi, Rikuo Takahashi, Kazunori Nakajima   +4 more
doaj   +1 more source