Results 11 to 20 of about 6,076,656 (241)

Localization, analysis and evolution of transposed human immunoglobulin VK genes [PDF]

, 1988
The localization of Vκ gene regions to chromosome 2, on which the κ locus is located, and to other chromosomes is described. The Vκ genes that have been transposed to other chromosomes are called orphons.
Klopstock, Thomas, Straubinger, Bernhard, Lötscher, Erika, Zachau, Hans G., Zimmer, Franz-Josef, Jaenichen, Rita, Grzeschik, Karl-Heinz   +6 more
core   +1 more source

Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

Communications Biology, 2021
Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme.
Maxime Lecerf, Alexia Kanyavuz, Sofia Rossini, Jordan D. Dimitrov   +3 more
doaj   +1 more source

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Schwirzke, Marina, Kaluzab, Brigitte, Weissenhorn, Winfried, Weiss, Elisabeth H., Weidle, Ulrich H.   +4 more
core   +1 more source

Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: chronic activation, normal selection [PDF]

, 2006
Autoimmune diseases show high diversity in the affected organs, clinical manifestations and disease dynamics. Yet they all share common features, such as the ectopic germinal centers found in many affected tissues.
Neta S. Zuckerman, Zuckerman, N.S., Michal Barak, Roshini S. Abraham, Ramit Mehr, Mehr, Ramit, Steiman-Shimony, Avital, David I. Stott, Edelman, H., Hutzler, A., Edelman, Hanna, Zuckerman, Neta S., Stott, David I., Shahaf, G., Deborah Dunn-Walters, Abraham, Roshim S., Shahaf, Gitit, Stott, D.I., Gitit Shahaf, Dunn-Walters, D., Avital Steiman-Shimony, Hutzler, Anat, Barak, M., Steiman-Shimony, A., Barak, Michal, Mehr, R., Dunn-Walters, Deborah, Anat Hutzler, Hanna Edelman, Abraham, R.S.   +29 more
core   +1 more source

Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire

Frontiers in Immunology, 2021
Vast repertoires of unique antigen receptors are created in developing B and T lymphocytes. The antigen receptor loci contain many variable (V), diversity (D) and joining (J) gene segments that are arrayed across very large genomic expanses and are ...
Amy L. Kenter, Corey T. Watson, Jan-Hendrik Spille   +2 more
doaj   +1 more source

Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases [PDF]

, 2006
Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for ...
Gitit Shahaf, Dunn-Walters, D., Avital Steiman-Shimony, Michal Barak, Roshini S. Abraham, Ramit Mehr, Abraham, Roshini S., Mehr, Ramit, Steiman-Shimony, Avital, Barak, M., Steiman-Shimony, A., David I. Stott, Edelman, H., Edelman, Hanna, Barak, Michal, Stott, David I., Mehr, R., Shahaf, G., Dunn-Walters, Deborah, Deborah Dunn-Walters, Hanna Edelman, Shahaf, Gitit, Abraham, R.S., Stott, D.I.   +23 more
core   +1 more source

Development of the expressed immunoglobulin μ chain repertoire during maturation of mice B cells [PDF]

Frontiers of Agricultural Science and Engineering, 2014
In the bone marrow and spleen, the developing B cell populations undergo both negative and positive selections to shape their B cell receptor repertoire.
Jingwen LIANG,Yingfeng LUO,Yi SUN,Meng LEI,Bing ZHANG,Songnian HU,Yaofeng ZHAO
doaj   +1 more source

Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4 [PDF]

, 2004
86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
Darlow, J.M., Farrell, A.M., John M. Darlow, David I. Stott, Stott, D.I., Alex M. Farrell   +5 more
core   +1 more source

Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS.

PLoS ONE, 2020
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an unexplained chronic, debilitating illness characterized by fatigue, sleep disturbances, cognitive dysfunction, orthostatic intolerance and gastrointestinal problems.
Milica Milivojevic, Xiaoyu Che, Lucinda Bateman, Aaron Cheng, Benjamin A Garcia, Mady Hornig, Manuel Huber, Nancy G Klimas, Bohyun Lee, Hyoungjoo Lee, Susan Levine, Jose G Montoya, Daniel L Peterson, Anthony L Komaroff, W Ian Lipkin   +14 more
doaj   +1 more source

The immunoglobulin κ gene families of human and mouse: a cottage industry approach [PDF]

, 2000
Some aspects of the work of our group on the human and mouse immunoglobulin κ genes are reviewed. The human κ locus contains a large duplication: a 600 kb C κ-proximal copy with 40 V κ genes is found in the close vicinity of a 440 kb C κ-distal copy with
Zachau, Hans G.
core   +1 more source