Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene region [PDF]
BMC Genomics, 2011 Background Segmental duplication and deletion were implicated for a region containing the human immunoglobulin heavy chain variable (IGHV) gene segments, 1.9III/hv3005 (possible allelic variants of IGHV3-30) and hv3019b9 (a possible allelic variant of ...
Gao Richeng +7 more
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[Application of next-generation sequencing technology for the investigation of immunoglobulin variable region characteristics and their prognostic significance in patients with chronic lymphocytic leukemia]. [PDF]
Zhonghua Xue Ye Xue Za ZhiGuo Z +12 more
europepmc +3 more sources
Activation and Tolerance in CD4+ T Cells Reactive to an Immunoglobulin Variable Region [PDF]
Journal of Experimental Medicine, 2004 Antibody diversity creates an immunoregulatory challenge for T cells that must cooperate with B cells, yet discriminate between self and nonself. To examine the consequences of T cell reactions to the B cell receptor (BCR), we generated a transgenic (Tg) line of mice expressing a T cell receptor (TCR) specific for a κ variable region peptide in ...
Christopher M Snyder, Lawrence J Wysocki
exaly +3 more sources
Immunoglobulin heavy chain variable region analysis in dairy goats
Immunobiology, 2018 Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is present on seven genome scaffolds, and contains ten VH, three DH and six JH segments. After the exclusion of three shorter segments, the VH genes were divided into two gene families based on ...
Abdul Basit, Qingwang Li, Xiuzhu Sun
exaly +3 more sources
Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region. [PDF]
Proc Natl Acad Sci U S A, 2018 van de Bovenkamp FS +17 more
europepmc +3 more sources
Immunoglobulin Heavy Chain Locus Variable Region Mutation [PDF]
, 2020 National Cancer Institute
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mAbs, 2020 The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire.
Samuel Schmitz +3 more
doaj +1 more source
Controlling somatic hypermutation in immunoglobulin variable and switch regions [PDF]
Immunologic Research, 2010 Activation-induced deaminase (AID) is a B-cell-specific enzyme required for initiating the mechanisms of affinity maturation and isotype switching of antibodies. AID functions by deaminating cytosine to uracil in DNA, which initiates a cascade of events resulting in mutations and strand breaks in the immunoglobulin loci. There is an intricate interplay
Robert W, Maul, Patricia J, Gearhart
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mAbs, 2021 Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching +7 more
doaj +1 more source
Ig constant region effects on variable region structure and function
Frontiers in Microbiology, 2016 The adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for ...
Alena eJanda +3 more
doaj +1 more source