Results 41 to 50 of about 394,452 (270)

Diversity in the Cow Ultralong CDR H3 Antibody Repertoire

Frontiers in Immunology, 2018
Typical antibodies found in humans and mice usually have short CDR H3s and generally flat binding surfaces. However, cows possess a subset of antibodies with ultralong CDR H3s that can range up to 70 amino acids and form a unique “stalk and knob ...
Jeremy K. Haakenson, Ruiqi Huang, Vaughn V. Smider   +2 more
doaj   +1 more source

Intratumoral T-cell and B-cell receptor architecture associates with distinct immune tumor microenvironment features and clinical outcomes of anti-PD-1/L1 immunotherapy

Journal for ImmunoTherapy of Cancer, 2023
Background Effective cooperation between B-cells and T-cells within the tumor microenvironment may lead to the regression of established tumors. B-cells and T-cells can recognize tumor antigens with exquisite specificity via their receptor complexes ...
Marco Donia, Göran Jönsson, Inge Marie Svane, Aimilia Schina, Zsofia Sztupinszki, Zoltan Szallasi   +5 more
doaj   +1 more source

Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus [PDF]

, 2014
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the reasons for its unusual severity among young adults.
A. Rambaut, Adalja, Antonovics, Davenport, Dowdle, Fan, FROST, G.-Z. Han, Kawaoka, KENDAL, M. Worobey, Masurel, Masurel, Masurel, Masurel, Molinari, Morens, Mulder, Nelson, REKART, SCHOENBAUM, Schulman, Shanks, Shanks, Taubenberger, Thompson, Thompson, Waffarn, Webster, Wolfe   +29 more
core   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. [PDF]

, 1994
Polyreactive antibodies (Abs) constitute a major proportion of the early Ab repertoire and are an important component of the natural defense mechanisms against infections.
Casali, P, Ichiyoshi, Y
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains

Frontiers in Immunology, 2019
Antigen recognition by mammalian antibodies represents the most diverse setting for protein-protein interactions, because antibody variable regions contain exceptionally diverse variable gene repertoires of DNA sequences containing combinatorial, non ...
Jinhui Dong, Jessica A. Finn, Peter A. Larsen, Timothy P. L. Smith, James E. Crowe, James E. Crowe, James E. Crowe   +6 more
doaj   +1 more source

Population dynamics of rhesus macaques and associated foamy virus in Bangladesh. [PDF]

, 2013
Foamy viruses are complex retroviruses that have been shown to be transmitted from nonhuman primates to humans. In Bangladesh, infection with simian foamy virus (SFV) is ubiquitous among rhesus macaques, which come into contact with humans in diverse ...
Andreina Pacheco, M, Barry, Peter A, Craig, Karen L, Engel, Gregory A, Escalante, Ananias A, Feeroz, Mostafa M, Jackson, Dana L, Jones-Engel, Lisa, Kamrul Hasan, M, Lee, Eun-Gyung, Lerche, Nicholas W, Levine, Kathryn L, Linial, Maxine L, Matsen Iv, Frederick A, Oh, Gunwha, Rabiul Alam, SM, Small, Christopher T, Soliven, Khanh, Wang, Xiaoxing, Yee, JoAnn L   +19 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source