Results 41 to 50 of about 1,539 (210)

An expandable synthetic library of human paired antibody sequences.

PLoS Computational Biology
The potential diversity in the global repertoire of human antibody sequences is currently not well understood due to the limited existing paired antibody heavy-light chain sequence data that has been hindered by the low throughput and high costs of ...
Toma M Marinov, Perry T Wasdin, Gwen Jordaan, Alexis K Janke, Alexandra A Abu-Shmais, Ivelin S Georgiev   +5 more
doaj   +1 more source

The Plasmodium falciparum merozoite surface protein-1 19 KD antibody response in the Peruvian Amazon predominantly targets the non-allele specific, shared sites of this antigen

Malaria Journal, 2010
Background Plasmodium falciparum re-emerged in Iquitos, Peru in 1994 and is now hypoendemic (< 0.5 infections/person/year). Purportedly non-immune individuals with discrete (non-overlapping) P.
Silva Claudia, Clark Eva H, Sutton Patrick L, Branch OraLee H   +3 more
doaj   +1 more source

Generation of synthetic antibody fragments with optimal complementarity determining region lengths for Notch-1 recognition

Frontiers in Microbiology, 2022
Synthetic antibodies have been engineered against a wide variety of antigens with desirable biophysical, biochemical, and pharmacological properties.
Bharathikumar Vellalore Maruthachalam, Kris Barreto, Daniel Hogan, Anthony Kusalik, Clarence Ronald Geyer   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Animal immunization merges with innovative technologies: A new paradigm shift in antibody discovery

mAbs, 2021
Animal-derived antibody sources, particularly, transgenic mice that are engineered with human immunoglobulin loci, along with advanced antibody generation technology platforms have facilitated the discoveries of human antibody therapeutics.
Ponraj Prabakaran, Sambasiva P Rao, Maria Wendt   +2 more
doaj   +1 more source

Diverse Roles of Antibodies in Antibody–Drug Conjugates

Pharmaceuticals
The emergence of antibody–drug conjugates (ADCs) has transformed the treatment landscape of a variety of cancers. ADCs typically consist of three main components: monoclonal antibody, chemical linker, and cytotoxic payload. These integrated therapeutic modalities harness the benefits of each component to provide a therapeutic response that cannot be ...
Aiko Yamaguchi, H. Charles Manning
openaire   +3 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Bats generate lower affinity but higher diversity antibody responses than those of mice, but pathogen-binding capacity increases if protein is restricted in their diet.

PLoS Biology
Bats are reservoirs of many zoonotic viruses that are fatal in humans but do not cause disease in bats. Moreover, bats generate low neutralizing antibody titers in response to experimental viral infection, although more robust antibody responses have ...
Daniel E Crowley, Caylee A Falvo, Evelyn Benson, Jodi Hedges, Mark Jutila, Shahrzad Ezzatpour, Hector C Aguilar, Manuel Ruiz-Aravena, Wenjun Ma, Tony Schountz, Agnieszka Rynda-Apple, Raina K Plowright   +11 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source