Results 51 to 60 of about 394,452 (270)

Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis

Frontiers in Immunology, 2017
The identification of mutations that enhance antibody affinity while maintaining high antibody specificity and stability is a time-consuming and laborious process.
Kathryn E. Tiller, Ratul Chowdhury, Tong Li, Seth D. Ludwig, Sabyasachi Sen, Costas D. Maranas, Peter M. Tessier   +6 more
doaj   +1 more source

Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines [PDF]

, 2014
BackgroundPolymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development.
Anders, Robin F., Barry, Alyssa E., Beeson, James G., Cross, Nadia J., Drew, Damien R., Dutta, Sheetij, Elliott, Salenna R., Hodder, Anthony N., Marsh, Kevin, Mueller, Ivo, Mugyenyi, Cleopatra K., Osier, Faith, Richards, Jack S., Senn, Nicolas, Siba, Peter M., Stanisic, Danielle I., Terheggen, Ulrich   +16 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting

BMC Microbiology, 2009
Background Genetic evidence for diversifying selection identified the Merozoite Surface Protein1 block2 (PfMSP1 block2) as a putative target of protective immunity against Plasmodium falciparum.
Trape Jean-François, Ohashi Jun, Patarapotikul Jintana, Bouchier Christiane, Bischoff Emmanuel, Guillotte Micheline, Ekala Marie-Thérèse, Sokhna Cheikh, Tall Adama, Marrama Laurence, Jouin Hélène, Prugnolle Franck, Noranate Nitchakarn, Rogier Christophe, Mercereau-Puijalon Odile   +14 more
doaj   +1 more source

Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates.

PLoS Pathogens, 2021
The development of an effective human immunodeficiency virus (HIV-1) vaccine is a high global health priority. Soluble native-like HIV-1 envelope glycoprotein trimers (Env), including those based on the SOSIP design, have shown promise as vaccine ...
Jelle van Schooten, Marlies M van Haaren, Hui Li, Laura E McCoy, Colin Havenar-Daughton, Christopher A Cottrell, Judith A Burger, Patricia van der Woude, Leanne C Helgers, Ilhan Tomris, Celia C Labranche, David C Montefiori, Andrew B Ward, Dennis R Burton, John P Moore, Rogier W Sanders, Shane Crotty, George M Shaw, Marit J van Gils   +18 more
doaj   +1 more source

Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires

, 2019
The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity.
Abbas, Adams, Adli, Alipanahi, Alpert, AlQuraishi, Altan-Bonnet, Angeletti, Angermueller, Antunes, Arora, Arora, Arora, Azizi, Ba, Bachmann, Bandeira, Baran, Barlow, Bashford-Rogers, Bashor, Bassani-Sternberg, Bassani-Sternberg, Bassani-Sternberg, Bassing, Baumgarth, Ben-Hamo, Benjamin, Benjamin, Bentzen, Bentzen, Bepler, Bethune, Bhat, Birnbaum, Biswas, Blythe, Bolotin, Bongartz, Boyd, Bradbury, Bradley, Breden, Brenner, Briggs, Briney, Britanova, Broere, Brown, Buenrostro, Bulik-Sullivan, Burnett, Busse, Cao, Carey, Carmona, Carreno, Casadevall, Casini, Chaudhary, Chen, Cheow, Cheung, Chevalier, Ching, Christina Fan, Cinelli, Cobey, Cohen, Cohen, Cole, Corcoran, Correia, Corrie, Croote, Cybenko, Daberdaku, Dash, Davies, Davis, Davis, Davis, De Neuter, Deac, DeKosky, DeKosky, Devilder, Devulapally, DeWitt, DeWitt 3rd, DeWitt III, Dey, Ecker, Egorov, Egorov, EL-Manzalawy, EL-Manzalawy, EL-Manzalawy, Elgundi, Elhanati, Elhanati, Elhanati, Elhanati, Elton, Emerson, Emini, Esteva, Eyer, Farlik, Farmer, Farmer, Fellouse, Ferdous, Fine, Fink, Fischer, Fischman, Fishman, Flower, Fowler, Frank, Friedensohn, Galperin, Galson, Gee, Gee, Geering, Gentiluomo, Georgiev, Georgiou, Gidoni, Gielis, Glanville, Glanville, Goddard, Goldstein, Goodfellow, Goodfellow, Gowthaman, Graf, Greaves, Greenbaum, Greenspan, Greenspan, Greenspan, Greiff, Greiff, Greiff, Greiff, Greiff, Griffiths, Grigaityte, Guo, Guo, Hadrup, Halperin, Han, Han, Hartweger, Hashimshony, Hashimshony, Haynes, He, Heather, Heather, Hebditch, Heemskerk, Hellman, Hillman, Hochgerner, Hochreiter, Hochreiter, Hoehn, Hoehn, Holder, Holland, Holzinger, Hoogenboom, Hopp, Hornik, Hou, Howie, Hua, Huang, Imkeller, Irvine, Ishino, Islam, Islam, Jackson, Jackson, Jacobs, Jacobsen, Jacobsen, Jain, Jain, Jaitin, Janin, Jardine, Jardine, Jeanbart, Jerne, Jespersen, Joglekar, Jokinen, June, Jyothi, Kabat, Kanyavuz, Kaplon, Karplus, Keich, Keskin, Khosravi-Maharlooei, Kieke, Kingma, Kisielow, Klambauer, Klebanoff, Konishi, Korn, Kotzias, Kovaltsuk, Kramer, Krawczyk, Krawczyk, Krawczyk, Kringelum, Kunik, Kunik, Kuroda, Lanchantin, Lanzarotti, Lapidoth, Lapidoth, Laplane, Larsen, Lauer, Lavinder, Lavoie, LeCun, Lee, Lee, Legutki, Legutki, Levitt, Li, Li, Li, Li, Liberis, Lindeman, Linette, Liu, Liu, Liu, Liu, Lollier, Longo, Lu, Luo, Luo, Luo, López-Santibáñez-Jácome, Løset, MacBeath, Macosko, Madi, Madi, Mahajan, Manavalan, Manczinger, Mangul, Mangul, Marchalonis, Marcou, Margalit, Marrack, Marrack, Marrack, Martin, Martin, Mascola, Mason, Mason, Mayer, McDaniel, Meng, Merbl, Meysman, Mian, Migalska, Miho, Miho, Minhas, Moffett, Mohan, Mora, Mora, Murphy, Murugan, Muyldermans, Navalkar, Nemazee, Newell, Newell, Newell, Nimrod, North, Oakes, Ohlin, Olson, Ostmeyer, Ostmeyer, Ott, Ott, Padlan, Palme, Parker, Parola, Patterson, Pellequer, Perelson, Perelson, Persson, Peterson, Picelli, Pierce, Pittala, Pogorelyy, Pogorelyy, Pogson, Ponomarenko, Ponomarenko, Pou, Preuer, Priel, Purwada, Purwada, Quang, Radbruch, Ramos-López, Ramsköld, Raybould, Remington, Reshetova, Ribeiro, Richards, Richman, Riley, Rives, Rizzetto, Robert, Robins, Robins, Robinson, Rosati, Rosenberg, Rosenblatt, Rubelt, Rubinstein, Sahin, Saikia, Sandve, Sandve, Sblattero, Schmitt, Schneider, Schneider-Hohendorf, Schroeder, Schumacher, Schwab, Scott, Seet, Segler, Seimetz, Sela-Culang, Sela-Culang, Sela-Culang, Sethna, Sethna, Setliff, Sette, Sewell, Shah, Shalev-Shwartz, Sharon, Shaw, Shokri, Shugay, Shugay, Sidhom, Sidhom, Sikorski, Simonovsky, Simonyan, Sircar, Sircar, Slocombe, Smallwood, Soto, Spiess, Stoeckius, Stone, Strauli, Stubbington, Stubbington, Sundararajan, Swartz, Sylwester, Szegedy, Tague, Talmage, Tang, Taussig, Thakkar, Thomas, Thomas, Tickotsky, Tiller, Tirosh, Tompa, Tonegawa, Townsend, Trepel, Trolle, Turchaninova, Turner, Udyavar, Vamathevan, van der Schoot, Van Regenmortel, Venturi, Verkoczy, Vollmers, Voss, Vázquez Bernat, Wainberg, Walsh, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wardemann, Wardemann, Wardemann, Watson, Weinstein, Weitzner, Weitzner, Whitehead, Williams, Wine, Wine, Wirth, Woese, Wucherpfennig, Wurch, Xu, Xu, Xu, Yaari, Yaari, Yager, Yang, Younger, Zandian, Zarnitsyna, Zhang, Zhang, Zhao, Zhao, Zhao, Zheng, Zirlik, Zong   +478 more
core   +1 more source

Generation of Lamprey Monoclonal Antibodies (Lampribodies) Using the Phage Display System. [PDF]

, 2019
The variable lymphocyte receptors (VLRs) consist of leucine rich repeats (LRRs) and comprise the humoral antibodies produced by lampreys and hagfishes.
Amemiya, Chris T, Hansen, John D, Hassan, Khan MA, Herrin, Brantley R   +3 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes

Cell Reports, 2023
Summary: To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (VH), diversity (DH), and joining (JH ...
Olga Mielczarek, Carolyn H. Rogers, Yinxiu Zhan, Louise S. Matheson, Michael J.T. Stubbington, Stefan Schoenfelder, Daniel J. Bolland, Biola M. Javierre, Steven W. Wingett, Csilla Várnai, Anne Segonds-Pichon, Simon J. Conn, Felix Krueger, Simon Andrews, Peter Fraser, Luca Giorgetti, Anne E. Corcoran   +16 more
doaj   +1 more source

Infectious agents and inflammation. The role of microbiota in autoimmune arthritis [PDF]

, 2018
In higher vertebrates, mucosal sites at the border between the internal and external environments, directly interact with bacteria, viruses, and fungi.
D'Amelio, Raffaele, Picchianti-Diamanti, Andrea, Rosado, Maria M.   +2 more
core   +2 more sources