Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation
Frontiers in Immunology, 2019 Immunoglobulin (Ig) diversification occurs via somatic hypermutation (SHM) and class switch recombination (CSR), and is initiated by activation-induced deaminase (AID), which converts cytosine to uracil.
Ryan Costello, Amy Kenter
exaly +3 more sources
Modulation of Pleurodeles waltl DNA polymerase mu expression by extreme conditions encountered during spaceflight. [PDF]
PLoS ONE, 2013 DNA polymerase µ is involved in DNA repair, V(D)J recombination and likely somatic hypermutation of immunoglobulin genes. Our previous studies demonstrated that spaceflight conditions affect immunoglobulin gene expression and somatic hypermutation ...
Véronique Schenten +3 more
doaj +1 more source
Frontiers in Immunology, 2022 The COVID-19 pandemic shows that vaccination strategies building on an ancestral viral strain need to be optimized for the control of potentially emerging viral variants.
Lisa Paschold +11 more
doaj +1 more source
AID/APOBEC–dependent somatic hypermutation and DNA rearrangements of immunoglobulin and non-immunoglobulin genes [PDF]
Annals of Mechnikov's Institute, 2019 Editing Ig genes by activation induced deaminase (AID) initiates the antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR).
Kolotova T. +3 more
doaj +3 more sources
Histone H2A and H2B are monoubiquitinated at AID-targeted loci. [PDF]
PLoS ONE, 2010 Somatic hypermutation introduces base substitutions into the rearranged and expressed immunoglobulin (Ig) variable regions to promote immunity. This pathway requires and is initiated by the Activation Induced Deaminase (AID) protein, which deaminates ...
Glen M Borchert +4 more
doaj +1 more source
Nanopore sequencing approach for immunoglobulin gene analysis in chronic lymphocytic leukemia
Scientific Reports, 2021 The evaluation of the somatic hypermutation of the clonotypic immunoglobulin heavy variable gene has become essential in the therapeutic management in chronic lymphocytic leukemia patients.
Crescenzio Francesco Minervini +15 more
doaj +1 more source
Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. [PDF]
PLoS Biology, 2004 Depending on the species and the lymphoid organ, activation-induced cytidine deaminase (AID) expression triggers diversification of the rearranged immunoglobulin (Ig) genes by pseudo V (psiV) gene- templated gene conversion or somatic hypermutation.
Hiroshi Arakawa +2 more
doaj +1 more source
Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers
Cell Reports, 2018 Summary: Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be optimized to elicit high-affinity, protective antibodies after vaccination.
Carolyn E. Rydyznski +6 more
doaj +1 more source
Somatic hypermutation signature in B-cell low-grade lymphomas
Haematologica, 2008 Background Immunoglobulin gene somatic hypermutation is a biologically relevant and clinically useful prognostic factor in different types of low-grade B-cell lymphomas, including chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal ...
Lorraine Tracey +13 more
doaj +1 more source
Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes
Haematologica, 2012 Background Characterization of the immunoglobulin gene repertoire has improved our understanding of the immunopathogenesis of lymphoid tumors. Early B-lymphocyte precursors of multiple myeloma are known to exist and might be susceptible to antigenic ...
Simone Ferrero +24 more
doaj +1 more source