Results 11 to 20 of about 11,407 (198)
Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.
PLoS Biology, 2014 Somatic hypermutation (SH) generates point mutations within rearranged immunoglobulin (Ig) genes of activated B cells, providing genetic diversity for the affinity maturation of antibodies.
Jean-Marie Buerstedde +4 more
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Somatic immunoglobulin hypermutation [PDF]
Current Opinion in Immunology, 2002 Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence.
Marilyn, Diaz, Paolo, Casali
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DNA polymerases and somatic hypermutation of immunoglobulin genes [PDF]
The EMBO Reports, 2005 Somatic hypermutation of immunoglobulin variable genes, which increases antibody diversity, is initiated by the activation-induced cytosine deaminase (AID) protein. The current DNA-deamination model posits that AID deaminates cytosine to uracil in DNA, and that mutations are generated by DNA polymerases during replication or repair of the uracil ...
Mineaki, Seki +2 more
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Somatic hypermutation of immunoglobulin genes in human neonates [PDF]
Clinical and Experimental Immunology, 1997 SUMMARY The antibody response in the young infant is limited in several ways; in particular, responses generally are of low affinity and restricted to IgM. This raises the question whether the affinity maturation process, consisting of somatic mutation of immunoglobulin genes coupled with selection of high-affinity variants, is operative
Ridings, J. +5 more
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Brca1 in immunoglobulin gene conversion and somatic hypermutation [PDF]
DNA Repair, 2008 Defects in Brca1 confer susceptibility to breast cancer and genomic instability indicative of aberrant repair of DNA breaks. Brca1 was previously implicated in the homologous recombination pathway via effects on the assembly of recombinase Rad51. Activation-induced cytidine deaminase (AID) deaminates C to U in B lymphocyte immunoglobulin (Ig) DNA to ...
Simonne, Longerich +4 more
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The Role of DNA Repair in Somatic Hypermutation of Immunoglobulin Genes [PDF]
The Journal of Experimental Medicine, 1998 Immunoglobulin (Ig) genes are first modified through the V(D)J (V, variable; D, diversity; J, joining) recombination process in pre–B cells. The Rag1/Rag2-dependent V(D)J recombination generates a large repertoire of B lymphocytes, each expressing a unique antibody molecule.
N, Kim, U, Storb
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Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation [PDF]
Immunity, 1996 To identify DNA sequences that target the somatic hypermutation process, the immunoglobulin gene promoter located upstream of the variable (V) region was duplicated upstream of the constant (C) region of a kappa transgene. Normally, kappa genes are somatically mutated only in the VJ region, but not in the C region.
Peters, Andrew, Storb, Ursula
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Frontiers in Immunology, 2022 The mechanisms of B-cell diversification differ greatly between aves and mammals, but both produce B cells and antibodies capable of supporting an effective immune response.
Jessica Mallaby +5 more
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Failure to detect functional neutrophil B helper cells in the human spleen. [PDF]
PLoS ONE, 2014 A novel role for human neutrophilic granulocytes was recently described, showing that these cells, upon entering the spleen, can be reprogrammed into a distinct B cell-helper neutrophil phenotype that is capable of eliciting B cell responses such as ...
Sietse Quirijn Nagelkerke +4 more
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Controlling somatic hypermutation in immunoglobulin variable and switch regions [PDF]
Immunologic Research, 2010 Activation-induced deaminase (AID) is a B-cell-specific enzyme required for initiating the mechanisms of affinity maturation and isotype switching of antibodies. AID functions by deaminating cytosine to uracil in DNA, which initiates a cascade of events resulting in mutations and strand breaks in the immunoglobulin loci. There is an intricate interplay
Robert W, Maul, Patricia J, Gearhart
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