Results 11 to 20 of about 11,197 (138)

Histone H2A and H2B are monoubiquitinated at AID-targeted loci. [PDF]

PLoS ONE, 2010
Somatic hypermutation introduces base substitutions into the rearranged and expressed immunoglobulin (Ig) variable regions to promote immunity. This pathway requires and is initiated by the Activation Induced Deaminase (AID) protein, which deaminates ...
Glen M Borchert, Nathaniel W Holton, Kevin A Edwards, Laura A Vogel, Erik D Larson   +4 more
doaj   +1 more source

AID/APOBEC–dependent somatic hypermutation and DNA rearrangements of immunoglobulin and non-immunoglobulin genes [PDF]

Annals of Mechnikov's Institute, 2019
Editing Ig genes by activation induced deaminase (AID) initiates the antibody diversification process in B lymphocytes.In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR).The activity of AID is ...
T Kolotova, V Makarenko, L Sorokoumova, M Davidenko   +3 more
doaj   +2 more sources

Nanopore sequencing approach for immunoglobulin gene analysis in chronic lymphocytic leukemia

Scientific Reports, 2021
The evaluation of the somatic hypermutation of the clonotypic immunoglobulin heavy variable gene has become essential in the therapeutic management in chronic lymphocytic leukemia patients.
Crescenzio Francesco Minervini, Cosimo Cumbo, Immacolata Redavid, Maria Rosa Conserva, Paola Orsini, Antonella Zagaria, Luisa Anelli, Nicoletta Coccaro, Giuseppina Tota, Luciana Impera, Elisa Parciante, Francesco Tarantini, Annamaria Giordano, Giorgina Specchia, Pellegrino Musto, Francesco Albano   +15 more
doaj   +1 more source

Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. [PDF]

PLoS Biology, 2004
Depending on the species and the lymphoid organ, activation-induced cytidine deaminase (AID) expression triggers diversification of the rearranged immunoglobulin (Ig) genes by pseudo V (psiV) gene- templated gene conversion or somatic hypermutation.
Hiroshi Arakawa, Huseyin Saribasak, Jean-Marie Buerstedde   +2 more
doaj   +1 more source

Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers

Cell Reports, 2018
Summary: Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be optimized to elicit high-affinity, protective antibodies after vaccination.
Carolyn E. Rydyznski, Stacey A. Cranert, Julian Q. Zhou, Heping Xu, Steven H. Kleinstein, Harinder Singh, Stephen N. Waggoner   +6 more
doaj   +1 more source

Somatic hypermutation signature in B-cell low-grade lymphomas

Haematologica, 2008
Background Immunoglobulin gene somatic hypermutation is a biologically relevant and clinically useful prognostic factor in different types of low-grade B-cell lymphomas, including chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal ...
Lorraine Tracey, Mohit Aggarwal, Mónica García-Cosio, Raquel Villuendas, Patrocinio Algara, Margarita Sánchez-Beato, Abel Sánchez-Aguilera, Juan F. García, Antonia Rodríguez, Francisca I. Camacho, Nerea Martínez, Elena Ruiz-Ballesteros, Manuela Mollejo, Miguel Á. Piris   +13 more
doaj   +1 more source

Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes

Haematologica, 2012
Background Characterization of the immunoglobulin gene repertoire has improved our understanding of the immunopathogenesis of lymphoid tumors. Early B-lymphocyte precursors of multiple myeloma are known to exist and might be susceptible to antigenic ...
Simone Ferrero, Daniela Capello, Mirija Svaldi, Michela Boi, Daniela Gatti, Daniela Drandi, Davide Rossi, Sara Barbiero, Barbara Mantoan, Elisabetta Mantella, Manuela Zanni, Paola Ghione, Alessandra Larocca, Roberto Passera, Francesco Bertoni, Valter Gattei, Francesco Forconi, Luca Laurenti, Giovanni Del Poeta, Roberto Marasca, Sergio Cortelazzo, Gianluca Gaidano, Antonio Palumbo, Mario Boccadoro, Marco Ladetto   +24 more
doaj   +1 more source

Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation

Frontiers in Immunology, 2019
Immunoglobulin (Ig) diversification occurs via somatic hypermutation (SHM) and class switch recombination (CSR), and is initiated by activation-induced deaminase (AID), which converts cytosine to uracil.
Ryan Costello, Jose F. Cantillo, Amy L. Kenter   +2 more
doaj   +1 more source

Chickens, more than humans, focus the diversity of their immunoglobulin genes on the complementarity-determining region but utilise amino acids, indicative of a more cross-reactive antibody repertoire

Frontiers in Immunology, 2022
The mechanisms of B-cell diversification differ greatly between aves and mammals, but both produce B cells and antibodies capable of supporting an effective immune response.
Jessica Mallaby, Joseph Ng, Alex Stewart, Emma Sinclair, Deborah Dunn-Walters, Uri Hershberg   +5 more
doaj   +1 more source

Failure to detect functional neutrophil B helper cells in the human spleen. [PDF]

PLoS ONE, 2014
A novel role for human neutrophilic granulocytes was recently described, showing that these cells, upon entering the spleen, can be reprogrammed into a distinct B cell-helper neutrophil phenotype that is capable of eliciting B cell responses such as ...
Sietse Quirijn Nagelkerke, Daan Jacob aan de Kerk, Machiel Hugo Jansen, Timo Kars van den Berg, Taco Willem Kuijpers   +4 more
doaj   +1 more source