Results 31 to 40 of about 11,407 (198)
Frontiers in Immunology, 2022 Somatic hypermutation (SHM) is an important diversification mechanism that plays a part in the creation of immune memory. Immunoglobulin (Ig) variable region gene lineage trees were used over the last four decades to model SHM and the selection ...
Hadas Neuman +8 more
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PLoS Pathogens, 2020 One of the defining characteristics of the B cell receptor (BCR) is the extensive diversity in the repertoire of immunoglobulin genes that make up the BCR, resulting in broad range of specificity.
Christopher M Collins +4 more
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Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Antibodies are important for recovery from viral infections and vaccine efficacy. To improve the ability of antibodies to bind and neutralize viral pathogens, antibody DNA sequences undergo a mutational process driven by the enzyme activation-induced deaminase (AID). However, high levels of antibody mutations are required
Kalani, Halemano +6 more
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What Targets Somatic Hypermutation to the Immunoglobulin Loci?
Viral Immunology, 2020 One of the most profound enigmas in B cell biology is how activation-induced deaminase (AID) is targeted to a very small region of DNA in the immunoglobulin loci. Two specific regions are singled out: the variable region of 2 kb that contains rearranged genes on the heavy, κ light, and λ light chain loci, and the switch region of ∼4 kb that contains an
Justin M H, Heltzel +1 more
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Somatic hypermutation defects in two adult hyper immunoglobulin M patients
Immunologic Research, 2021 Abstract Hyper immunoglobulin M (HIGM) syndrome is a rare disorder of the immune system with impaired antibody functions. The clinical picture of the patients varies according to the underlying genetic variation. In this study, we identified two novel variants in AID and UNG genes, which are associated with autosomal recessive type HIGM, by ...
Hülya Yilmaz +4 more
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Genetics and Molecular Biology, 2008 Chronic lymphocytic leukaemia (CLL) is a haematological malignancy for which reliable prognostic markers are needed in view of its clinical heterogeneity.
Beatriz Jatobá Pimentel +4 more
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Cancer Biology & Medicine, 2011 Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma, originating from naı ¨ve B-cells. The blastoid MCL tumors often show complex cytogenetic aberrations. In this review, we summarized the data available on immunoglobulin heavy-chain (IgH)
Francesco Bertoni +6 more
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Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes [PDF]
The Journal of Experimental Medicine, 1998 During a germinal center reaction, random mutations are introduced into immunoglobulin V genes to increase the affinity of antibody molecules and to further diversify the B cell repertoire. Antigen-directed selection of B cell clones that generate high affinity surface Ig results in the affinity maturation of the antibody response.
P C, Wilson +6 more
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Cell Reports, 2019 Summary: Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD+IgM− plasmablasts constitute a major lymphocyte
Pedro Perdiguero +10 more
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On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes
Immunology & Cell Biology, 2004 Somatic hypermutation (SHM) diversifies the genes that encode immunoglobulin variable regions in antigen‐activated germinal centre B lymphocytes. Available evidence strongly suggests that DNA deamination potentiates phase I SHM and subsequently triggers phase II SHM.
Franklin, Andrew, Blanden, Robert
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