Results 31 to 40 of about 11,197 (138)

IgTreeZ, A Toolkit for Immunoglobulin Gene Lineage Tree-Based Analysis, Reveals CDR3s Are Crucial for Selection Analysis

Frontiers in Immunology, 2022
Somatic hypermutation (SHM) is an important diversification mechanism that plays a part in the creation of immune memory. Immunoglobulin (Ig) variable region gene lineage trees were used over the last four decades to model SHM and the selection ...
Hadas Neuman, Jessica Arrouasse, Meirav Kedmi, Meirav Kedmi, Meirav Kedmi, Andrea Cerutti, Andrea Cerutti, Giuliana Magri, Ramit Mehr   +8 more
doaj   +1 more source

Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment.

PLoS Pathogens, 2020
One of the defining characteristics of the B cell receptor (BCR) is the extensive diversity in the repertoire of immunoglobulin genes that make up the BCR, resulting in broad range of specificity.
Christopher M Collins, Christopher D Scharer, Thomas J Murphy, Jeremy M Boss, Samuel H Speck   +4 more
doaj   +1 more source

Use of V H, D and J H immunoglobulin gene segments in Brazilian patients with chronic lymphocytic leukaemia (CLL)

Genetics and Molecular Biology, 2008
Chronic lymphocytic leukaemia (CLL) is a haematological malignancy for which reliable prognostic markers are needed in view of its clinical heterogeneity.
Beatriz Jatobá Pimentel, Cláudio Gustavo Stefanoff, Aline Santos Moreira, Héctor N. Seuánez, Ilana Renault Zalcberg   +4 more
doaj   +1 more source

Biased Immunoglobulin Genes Rearrangement in Mantle Cell Lymphoma: Hints to Identify the Normal B-cell Counterpart

Cancer Biology & Medicine, 2011
Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma, originating from naı ¨ve B-cells. The blastoid MCL tumors often show complex cytogenetic aberrations. In this review, we summarized the data available on immunoglobulin heavy-chain (IgH)
Francesco Bertoni, Sergio B. Cogliatti, Daniela Capello, Xi-shan Hao, Hua-qing Wang, Hui-lai Zhang, Franco Cavalli   +6 more
doaj   +1 more source

Teleost IgD+IgM− B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles

Cell Reports, 2019
Summary: Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD+IgM− plasmablasts constitute a major lymphocyte
Pedro Perdiguero, Alba Martín-Martín, Ottavia Benedicenti, Patricia Díaz-Rosales, Esther Morel, Estefanía Muñoz-Atienza, Mónica García-Flores, Rocío Simón, Irene Soleto, Andrea Cerutti, Carolina Tafalla   +10 more
doaj   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

Fast-tracking antibody maturation using a B cell-based display system

mAbs, 2022
Affinity maturation, an essential component of antibody engineering, is crucial for developing therapeutic antibodies. Cell display system coupled with somatic hypermutation (SHM) initiated by activation-induced cytidine deaminase (AID) is a commonly ...
Hitomi Masuda, Atsushi Sawada, Shu-ichi Hashimoto, Kanako Tamai, Ke-Yi Lin, Naoto Harigai, Kohei Kurosawa, Kunihiro Ohta, Hidetaka Seo, Hiroshi Itou   +9 more
doaj   +1 more source

Post CAR‐T Measurable Residual Disease Monitoring in Mantle Cell Lymphoma Enables Early Detection of Disease Relapse

American Journal of Hematology, EarlyView.
ABSTRACT CD19‐directed chimeric antigen receptor (CAR) T‐cell therapy has transformed outcomes for patients with relapsed or refractory (r/r) mantle cell lymphoma (MCL), yet more than 40% relapse within one year. Early identification of patients at risk for progression could inform post CAR‐T surveillance and consolidation strategies.
Snegha Ananth, Neha Agarwal, Bita Sahaf, Allison Jacob, Lik Wee Lee, Heidi Simmons, Ilan Kirsch, Sushma Bharadwaj, Wen‐kai Weng, Melody Smith, Saurabh Dahiya, David Miklos, Matthew J. Frank   +12 more
wiley   +1 more source

Immunoglobulin genes and diversity: what we have learned from domestic animals

Journal of Animal Science and Biotechnology, 2012
This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α ...
Sun Yi, Liu Zhancai, Ren Liming, Wei Zhiguo, Wang Ping, Li Ning, Zhao Yaofeng   +6 more
doaj   +1 more source

Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies.

PLoS Computational Biology, 2022
Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene.
Cosimo Lupo, Natanael Spisak, Aleksandra M Walczak, Thierry Mora   +3 more
doaj   +1 more source