Results 51 to 60 of about 11,407 (198)

The Role of IgM Anti‐acetylated Protein Antibodies and B Cells in the Origin of Antimodified Protein Autoimmunity in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies (anti‐CarP), and anti‐acetylated protein antibodies (AAPA). In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role ...
Aegli Athanasiadou, Sanne Kroos, Renee van de Wetering, Rian Schopmeijer, Carin van der Keur, Michael Eikmans, Caroline Meijer, Solbritt Rantapää‐Dahlqvist, René E. M. Toes, Linda M. Slot, Diane van der Woude   +10 more
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

In vivo and in vitro studies of immunoglobulin gene somatic hypermutation [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001
Following antigen encounter, two distinct processes modify immunoglobulin genes. The variable region is diversified by somatic hypermutation while the constant region may be changed by class–switch recombination. Although both genetic events can occur concurrently within germinal centre B cells, there are examples of each occurring independently of the
J E, Sale, M, Bemark, G T, Williams, C J, Jolly, M R, Ehrenstein, C, Rada, C, Milstein, M S, Neuberger   +7 more
openaire   +2 more sources

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

DNA Breaks in Hypermutating Immunoglobulin Genes: Evidence for a Break-and-Repair Pathway of Somatic Hypermutation

Genetics, 2001
AbstractTo test the hypothesis that immunoglobulin gene hypermutation in vivo employs a pathway in which DNA breaks are introduced and subsequently repaired to produce mutations, we have used a PCR-based assay to detect and identify single-strand DNA breaks in λ1 genes of actively hypermutating primary murine germinal center B cells. We find that there
Q, Kong, N, Maizels
openaire   +2 more sources

Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences [PDF]

The Journal of Experimental Medicine, 2006
It is thought that gene conversion (GCV) and somatic hypermutation (SHM) of immunoglobulin (Ig) genes occur in two steps: the generation of uracils in DNA by activation-induced cytidine deaminase, followed by their subsequent repair by various DNA repair pathways to generate sequence-diversified products.
Yang, Shu Yuan, Fugmann, Sebastian D., Schatz, David G.   +2 more
openaire   +2 more sources

Classical Mus musculus Igκ enhancers support transcription but not high level somatic hypermutation from a V-lambda promoter in chicken DT40 cells. [PDF]

PLoS ONE, 2011
Somatic hypermutation (SHM) of immunoglobulin genes is initiated by activation-induced cytidine deaminase (AID) in activated B cells. This process is strictly dependent on transcription.
Naga Rama Kothapalli, Darrell D Norton, Sebastian D Fugmann   +2 more
doaj   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Induction of Somatic Hypermutation Is Associated with Modifications in Immunoglobulin Variable Region Chromatin [PDF]

Immunity, 2003
Somatic hypermutation (SHM) requires selective targeting of the mutational machinery to the variable region of the immunoglobulin heavy chain gene. The induction of SHM in the BL2 cell line upon costimulation is associated with hyperacetylation of the chromatin at the variable region but not at the constant region.
Woo, Caroline J., Martin, Alberto, Scharff, Matthew D.   +2 more
openaire   +2 more sources

High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution.

PLoS ONE, 2015
Understanding the dynamics of evolution of Follicular Lymphoma (FL) clones during disease progression is important for monitoring and targeting this tumor effectively. Genetic profiling of serial FL biopsies and examples of FL transmission following bone
Emanuela Carlotti, David Wrench, Guglielmo Rosignoli, Jacek Marzec, Ajanthah Sangaralingam, Lena Hazanov, Miri Michaeli, Simon Hallam, Tracy Chaplin, Sameena Iqbal, Maria Calaminici, Bryan Young, Ramit Mehr, Peter Campbell, Jude Fitzgibbon, John G Gribben   +15 more
doaj   +1 more source