Results 71 to 80 of about 11,197 (138)

Ubiquitination events that regulate recombination of immunoglobulin loci gene segments

Frontiers in Immunology, 2014
Programmed DNA mutagenesis events in the immunoglobulin (Ig) loci of developing B cells utilize the common and conserved mechanism of protein ubiquitination for subsequent proteasomal degradation to generate the required antigen-receptor diversity ...
Jaime eChao, Gerson eRothschild, Uttiya eBasu   +2 more
doaj   +1 more source

Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein

eLife, 2014
The activation induced cytidine deaminase (AID) protein is known to initiate somatic hypermutation, gene conversion or switch recombination by cytidine deamination within the immunoglobulin loci.
Jean-Marie Buerstedde, Noel Lowndes, David G Schatz   +2 more
doaj   +1 more source

Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesis

Frontiers in Immunology, 2014
Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes during B cell maturation and immune response.
Pilar M Dominguez, Rita eShaknovich, Rita eShaknovich   +2 more
doaj   +1 more source

A rare presentation of type 2 hyper IgM syndrome in a 17-year-old male: a case report and literature review

Alergologia Polska
Hyper IgM syndrome (HIGM) is a heterogeneous group of primary immunodeficiencies characterized by impaired immunoglobulin class switching, leading to elevated IgM levels and deficiencies in other antibody isotypes.
Öner Özdemir, Lütfi Kılınçkaya, Ece Tüsüz Önata, Ali Yousef, Raziq Rahmani   +4 more
doaj   +1 more source

DOT1L activity limits transcription elongation velocity and favors RNAPII pausing to facilitate mutagenesis by AID

Nature Communications
Activation-induced deaminase (AID) mutates immunoglobulin genes to initiate antibody diversification by class switch recombination and somatic hypermutation but can also target non-immunoglobulin loci with oncogenic consequences.
Poorani Ganesh Subramani, Noé Seija, Jana Ridani, Jonathan Boulais, Paul A. Donnelly, Mélanie Provencher, Halil Bagci, Christian Poitras, Jean-François Côté, François Robert, Javier M. Di Noia   +10 more
doaj   +1 more source

Onychomadesis in a Patient with Immunoglobulin Class Switch Recombination Deficiency

Iranian Journal of Allergy, Asthma and Immunology, 2008
Immunoglobulin class switch recombination deficiencies (Ig CSR deficiencies) or Hyper IgM syndromes (HIGM) are a group of primary immunodeficiency diseases, characterized by defective CD40 signaling of B cells resulting into a CSR and a somatic ...
Mojgan Safari, Nima Rezaei, Mehrdad Hajilooi, Asghar Aghamohammadi, Qiang Pan-Hammarstrom, Lennart Hammarstrom   +5 more
doaj  

Comparative evaluation of two NGS-based assays for somatic hypermutation analysis of IGHV genes in chronic lymphocytic leukemia. [PDF]

Blood Res
Kang Y, Lee H, Park YJ, Lee ST, Choi JR, Shin S.   +5 more
europepmc   +1 more source

Cold Agglutinin Disease-Like Genetic Signatures in Lymphoplasmacytic Lymphoma-Like Cases Challenge the WHO Fifth Edition Classification. [PDF]

EJHaem
Sato Y, Koyama D, Yamada S, Suzuki K, Fukatsu M, Oka Y, Hashimoto Y, Ikezoe T.   +7 more
europepmc   +1 more source

Adenoviral Inciting Antigen and Somatic Hypermutation in VITT. [PDF]

N Engl J Med
Wang JJ, Schönborn L, Warkentin TE, Müller L, Thiele T, Ulm L, Völker U, Ameling S, Franzenburg S, Kaderali L, Tzvetkova A, Colella A, Chataway T, Tan CW, Armour B, Troelnikov A, Rutten L, McCluskey J, Zahn R, Gordon TP, Greinacher A.   +20 more
europepmc   +1 more source

Epigenetic-Genetic Coupling and Understanding the Molecular and Cellular Basis of Lamarckian Inheritance. [PDF]

Int J Mol Sci
Lindley RA, Gorczynski RM, Steele EJ.
europepmc   +1 more source