Results 91 to 100 of about 11,407 (198)
Clinical and Experimental Neuroimmunology, Volume 17, Issue 3, August 2026.ABSTRACT Background IgG4‐related disease (IgG4‐RD) is a systemic, immune‐mediated, fibroinflammatory disorder with multiorgan involvement and variable clinical presentation, often creating diagnostic difficulty. Myasthenia gravis (MG) is an antibody‐mediated autoimmune disorder of the neuromuscular junction, most commonly associated with anti ...
Yumiko Yoshida +4 more
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Somatic Hypermutation of Immunoglobulin Genes [PDF]
Cell, 2002 Papavasiliou, F.Nina, Schatz, David G
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eLife, 2014 The activation induced cytidine deaminase (AID) protein is known to initiate somatic hypermutation, gene conversion or switch recombination by cytidine deamination within the immunoglobulin loci.
Jean-Marie Buerstedde +2 more
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Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Age‐associated B cells (ABCs) are a distinct B cell population characterized by coexpression of T‐bet and CD11c. First described in aged female mice and autoimmune‐prone strains, ABCs are now recognized to be associated with multiple human autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis,
Kira Rubtsova
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Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesis
Frontiers in Immunology, 2014 Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes during B cell maturation and immune response.
Pilar M Dominguez +2 more
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Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Preexisting immunity to influenza confers rapid protection against antigenically matched viruses but can also constrain responses to drifted variants. This review asks when and why prior infection or vaccination is protective versus detrimental, and which biological mechanisms—epitope masking by circulating antibody, inhibitory FcγRIIb ...
Annette Fox +2 more
wiley +1 more source
Somatic hypermutation of immunoglobulin ĸ light chain genes [PDF]
, 1996 Somatic hypermutation of immunoglobulin genes is a tightly controlled, site directed process. The nucleotide changes are targeted in the region surrounding the rearranged V gene segment of the heavy and light chain loci. The targeting of somatic mutation does neither require V region including the Vĸ promoter specific features nor a specific distance ...
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Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
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The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT CD4+ T cells orchestrate adaptive immunity against respiratory viruses through functionally distinct subsets, yet the qualitative differences between vaccine‐ and infection‐induced responses remain incompletely understood. This review summarizes current evidence on how CD4+ T cell subsets shape the magnitude, breadth, and durability of ...
Masato Kubo
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The Structure of Vertebrate Antigen Receptor Repertoires: An Evolutionary Perspective
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT In vertebrate adaptive immune systems, somatically diversified antigen receptors assume a central role in self/nonself discrimination. Attesting to the presence of a unique but unknown selective environment at early stages of vertebrate evolution, this facility emerged twice, in the ancestors of jawless and jawed vertebrates.
Thomas Boehm, Orlando B. Giorgetti
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