Results 101 to 110 of about 11,407 (198)

Interferon‐Mediated Regulation of Memory B Cell Identity and Function

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Memory B cells are essential for long‐lasting immunity induced by both encountered pathogens and vaccines. Functional diversity within the memory B cell pool is established through interactions between memory B cells and the environment in which they develop and reside.
Alana Kirn, Kim L. Good‐Jacobson
wiley   +1 more source

A rare presentation of type 2 hyper IgM syndrome in a 17-year-old male: a case report and literature review

Alergologia Polska
Hyper IgM syndrome (HIGM) is a heterogeneous group of primary immunodeficiencies characterized by impaired immunoglobulin class switching, leading to elevated IgM levels and deficiencies in other antibody isotypes.
Öner Özdemir, Lütfi Kılınçkaya, Ece Tüsüz Önata, Ali Yousef, Raziq Rahmani   +4 more
doaj   +1 more source

The Developmental and Functional Implications of Age‐Associated B Cells (ABCs) Across Tissue Microenvironments

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Age‐associated B cells (ABCs) are a dynamic B cell subset whose identity, development, and function are fundamentally shaped by the tissue microenvironments in which they reside. Primarily defined by expression of CD11c and T‐bet, ABCs arise across diverse contexts, including aging, infection, autoimmunity, and cancer, yet exhibit striking ...
Rebecca L. Francis, Jason S. Weinstein
wiley   +1 more source

Light Chain Crystalline Proximal Tubulopathy and Podocytopathy With Staining for Both Light and Heavy Chain Immunoglobulin

Nephrology, Volume 31, Issue 8, August 2026.
ABSTRACT A 69‐year‐old male patient presented with weight loss and proteinuria. His medical history included papillary thyroid carcinoma. Laboratory findings showed proteinuria and high κ light chain levels in both urine and serum. Bone marrow aspiration revealed plasma cell myeloma of the IgA‐κ type.
Seoyoung Choi, Kyung Chul Moon
wiley   +1 more source

DOT1L activity limits transcription elongation velocity and favors RNAPII pausing to facilitate mutagenesis by AID

Nature Communications
Activation-induced deaminase (AID) mutates immunoglobulin genes to initiate antibody diversification by class switch recombination and somatic hypermutation but can also target non-immunoglobulin loci with oncogenic consequences.
Poorani Ganesh Subramani, Noé Seija, Jana Ridani, Jonathan Boulais, Paul A. Donnelly, Mélanie Provencher, Halil Bagci, Christian Poitras, Jean-François Côté, François Robert, Javier M. Di Noia   +10 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

The contribution of somatic hypermutation to the diversity of serum immunoglobulin: dramatic increase with age.

Immunity, 2000
Although somatic mutation contributes to the diversity of only a minor fraction of B cells in mouse spleen or blood, its contribution to the diversity of serum immunoglobulin is unknown. We have devised an immunoassay to monitor mutated antibodies in serum using a monoclonal antibody that recognizes a VK only when mutated at its major intrinsic hot ...
Williams, Gareth T., Jolly, Christopher J., Köhler, Jenny, Neuberger, Michael S.   +3 more
openaire   +2 more sources

Targeting and Regulation of Immunoglobulin Gene Somatic Hypermutation and lsotype Switch Recombination

, 1995
Publisher Summary This chapter discusses some of the recent work that has addressed the mechanisms of these two processes, with particular emphasis on the use of engineered constructs, to identify genetic elements critical to activation or targeting. Somatic hypermutation introduces single-base changes in the rearranged variable regions, resulting in
M, Hengstschläger, N, Maizels, H, Leung
openaire   +2 more sources

Onychomadesis in a Patient with Immunoglobulin Class Switch Recombination Deficiency

Iranian Journal of Allergy, Asthma and Immunology, 2008
Immunoglobulin class switch recombination deficiencies (Ig CSR deficiencies) or Hyper IgM syndromes (HIGM) are a group of primary immunodeficiency diseases, characterized by defective CD40 signaling of B cells resulting into a CSR and a somatic ...
Mojgan Safari, Nima Rezaei, Mehrdad Hajilooi, Asghar Aghamohammadi, Qiang Pan-Hammarstrom, Lennart Hammarstrom   +5 more
doaj  

Molecular Aspects of Somatic Hypermutation of Immunoglobulin Genes

Cold Spring Harbor Symposia on Quantitative Biology, 1999
U, Storb, A, Peters, N, Kim, H M, Shen, G, Bozek, N, Michael, J, Hackett, E, Klotz, J D, Reynolds, L A, Loeb, T E, Martin   +10 more
openaire   +2 more sources