Tandem Substitutions in Somatic Hypermutation [PDF]
Frontiers in Immunology, 2022 Upon antigen recognition, activation-induced cytosine deaminase initiates affinity maturation of the B-cell receptor by somatic hypermutation (SHM) through error-prone DNA repair pathways. SHM typically creates single nucleotide substitutions, but tandem
Julieta H. Sepúlveda-Yáñez +10 more
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Antibody Dynamics Simulation—A Mathematical Exploration of Clonal Deletion and Somatic Hypermutation [PDF]
Biomedicines, 2023 We have employed mathematical modeling techniques to construct a comprehensive framework for elucidating the intricate response mechanisms of the immune system, facilitating a deeper understanding of B-cell clonal deletion and somatic hypermutation.
Zhaobin Xu +4 more
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Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity [PDF]
Frontiers in Immunology, 2023 IntroductionThe success of the human body in fighting SARS-CoV2 infection relies on lymphocytes and their antigen receptors. Identifying and characterizing clinically relevant receptors is of utmost importance.MethodsWe report here the application of a ...
Modi Safra +21 more
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The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential tumorigenic activity [PDF]
Tumour Virus ResearchSimian virus 40 (SV40) is a monkey virus with tumorigenic potential in rodents and is associated with several types of human cancers, including lymphomas.
Filip Šenigl +6 more
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AID function in somatic hypermutation and class switch recombination [PDF]
Acta Biochimica et Biophysica Sinica, 2022 Activation-induced cytidine deaminase (AID) initiates somatic hypermutation of immunoglobulin (Ig) gene variable regions and class switch recombination (CSR) of Ig heavy chain constant regions.
Yu Kefei
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Somatic Hypermutation: Another piece in the hypermutation puzzle [PDF]
Current Biology, 1995 AbstractStudies with transgenic mice are beginning to define the minimal requirements for the somatic hypermutation of immunoglobulin genes that is critical in the production of high-affinity antibodies.
Winter, D.B., Gearhart, P.J.
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Involvement of Rad18 in somatic hypermutation [PDF]
Proceedings of the National Academy of Sciences, 2006 Somatic hypermutation of Ig genes is initiated by transcription-coupled cytidine deamination in Ig loci. Error-prone processing of the resultant DNA lesions is thought to cause extensive mutagenesis, but it is presently an enigma how and why error-prone rather than error-free repair pathways are recruited.
Jürgen, Bachl +2 more
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Somatic CpG hypermutation is associated with mismatch repair deficiency in cancer [PDF]
Molecular Systems BiologySomatic hypermutation in cancer has gained momentum with the increased use of tumour mutation burden as a biomarker for immune checkpoint inhibitors.
Aidan Flynn +2 more
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Thrifty wide-context models of B cell receptor somatic hypermutation [PDF]
eLifeSomatic hypermutation (SHM) is the diversity-generating process in antibody affinity maturation. Probabilistic models of SHM are needed for analyzing rare mutations, understanding the selective forces guiding affinity maturation, and understanding the ...
Kevin Sung +6 more
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Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
Cell Reports, 2019 Summary: Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome.
Yaakov Maman +2 more
exaly +3 more sources