Tandem Substitutions in Somatic Hypermutation [PDF]
Frontiers in Immunology, 2022 Upon antigen recognition, activation-induced cytosine deaminase initiates affinity maturation of the B-cell receptor by somatic hypermutation (SHM) through error-prone DNA repair pathways. SHM typically creates single nucleotide substitutions, but tandem
Julieta H. Sepúlveda-Yáñez +10 more
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Antibody Dynamics Simulation—A Mathematical Exploration of Clonal Deletion and Somatic Hypermutation [PDF]
Biomedicines, 2023 We have employed mathematical modeling techniques to construct a comprehensive framework for elucidating the intricate response mechanisms of the immune system, facilitating a deeper understanding of B-cell clonal deletion and somatic hypermutation.
Zhaobin Xu +4 more
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Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity [PDF]
Frontiers in Immunology, 2023 IntroductionThe success of the human body in fighting SARS-CoV2 infection relies on lymphocytes and their antigen receptors. Identifying and characterizing clinically relevant receptors is of utmost importance.MethodsWe report here the application of a ...
Modi Safra +21 more
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AID function in somatic hypermutation and class switch recombination [PDF]
Acta Biochimica et Biophysica Sinica, 2022 Activation-induced cytidine deaminase (AID) initiates somatic hypermutation of immunoglobulin (Ig) gene variable regions and class switch recombination (CSR) of Ig heavy chain constant regions.
Yu Kefei
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The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential tumorigenic activity [PDF]
Tumour Virus ResearchSimian virus 40 (SV40) is a monkey virus with tumorigenic potential in rodents and is associated with several types of human cancers, including lymphomas.
Filip Šenigl +6 more
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Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
Cell Reports, 2019 Summary: Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome.
David Weisz +2 more
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Thrifty wide-context models of B cell receptor somatic hypermutation [PDF]
eLifeSomatic hypermutation (SHM) is the diversity-generating process in antibody affinity maturation. Probabilistic models of SHM are needed for analyzing rare mutations, understanding the selective forces guiding affinity maturation, and understanding the ...
Kevin Sung +6 more
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B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S [PDF]
iScienceSummary: The viral vector-based COVID-19 vaccine Ad26.COV2.S has been recommended by the WHO since 2021 and has been administered to over 200 million people.
Catherine Jacob-Dolan +15 more
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The reverse transcriptase model of somatic hypermutation [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2001 The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human BCL–6 gene can be interpreted in terms of
Edward John Steele +2 more
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Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Linda Baughn +2 more
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