Results 21 to 30 of about 18,035 (205)

V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species

Frontiers in Immunology, 2018
An important characteristic of chickens is that the antibody repertoire is based on a single framework, with diversity found mainly in the CDRs of the light and heavy chain variable regions.
Philip A. Leighton, Jacqueline Morales, William D. Harriman, Kathryn H. Ching   +3 more
doaj   +1 more source

Somatic Hypermutation: Another piece in the hypermutation puzzle [PDF]

Current Biology, 1995
AbstractStudies with transgenic mice are beginning to define the minimal requirements for the somatic hypermutation of immunoglobulin genes that is critical in the production of high-affinity antibodies.
Winter, D.B., Gearhart, P.J.
openaire   +2 more sources

Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants

Nature Communications, 2023
In this study, authors identified neutralizing antibodies by isolating B cells from SARS-CoV-2 Delta infected patients and detect altered structural features, likely introduced by somatic hypermutation, that are involved in epitope binding and increase ...
Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang   +38 more
doaj   +1 more source

Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe

Frontiers in Immunology, 2023
The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem.
Luis Del Pozo-Yauner, Guillermo A. Herrera, Julio I. Perez Carreon, Elba A. Turbat-Herrera, Elba A. Turbat-Herrera, Francisco J. Rodriguez-Alvarez, Robin A. Ruiz Zamora   +6 more
doaj   +1 more source

Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens

Frontiers in Immunology, 2022
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged continuously, challenging the effectiveness of vaccines, diagnostics, and treatments.
Matheus Oliveira de Souza, Matheus Oliveira de Souza, Bharat Madan, Bharat Madan, I-Ting Teng, Aric Huang, Lihong Liu, Ahmed S. Fahad, Sheila N. Lopez Acevedo, Xiaoli Pan, Mallika Sastry, Matias Gutierrez-Gonzalez, Michael T. Yin, Tongqing Zhou, David D. Ho, Peter D. Kwong, Peter D. Kwong, Brandon J. DeKosky, Brandon J. DeKosky, Brandon J. DeKosky, Brandon J. DeKosky   +20 more
doaj   +1 more source

Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression

Haematologica, 2008
Background Follicular lymphoma is characterized by the t(14;18) translocation resulting in constitutive expression of BCL-2 protein; however approximately 10–15% of follicular lymphomas do not express BCL-2 protein, and a small fraction of these cases ...
Éva Gagyi, Zsófia Balogh, Csaba Bödör, Botond Timár, Lilla Reiniger, Linda Deák, Judit Csomor, Balázs Csernus, Ágota Szepesi, András Matolcsy   +9 more
doaj   +1 more source

Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors

Frontiers in Immunology, 2018
Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination.
Alexey N. Davydov, Anna S. Obraztsova, Anna S. Obraztsova, Mikhail Y. Lebedin, Maria A. Turchaninova, Maria A. Turchaninova, Maria A. Turchaninova, Dmitriy B. Staroverov, Dmitriy B. Staroverov, Ekaterina M. Merzlyak, Ekaterina M. Merzlyak, George V. Sharonov, George V. Sharonov, Olga Kladova, Mikhail Shugay, Mikhail Shugay, Mikhail Shugay, Mikhail Shugay, Olga V. Britanova, Olga V. Britanova, Olga V. Britanova, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov   +25 more
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Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory

Frontiers in Immunology, 2017
The evidence for the reverse transcriptase mechanism of somatic hypermutation is substantial and multifactorial. In this 60th anniversary year of the publication of Sir MacFarlane Burnet’s Clonal Selection Theory, the evidence is briefly reviewed and ...
Edward J. Steele
doaj   +1 more source

Characteristics of Pan-Cancer Patients With Ultrahigh Tumor Mutation Burden

Frontiers in Oncology, 2021
BackgroundTumor mutation burden has been proven to be a good predictor for the efficacy of immunotherapy, especially in patients with hypermutation. However, most research focused on the analysis of hypermutation in individual tumors, and there is a lack
Hong Yuan, Jun Ji, Min Shi, Yan Shi, Jing Liu, Junwei Wu, Chen Yang, Wenqi Xi, Qingyuan Li, Wei Zhu, Jingjie Li, Xiaoli Gong, Jun Zhang, Jun Zhang   +13 more
doaj   +1 more source

Involvement of Rad18 in somatic hypermutation [PDF]

Proceedings of the National Academy of Sciences, 2006
Somatic hypermutation of Ig genes is initiated by transcription-coupled cytidine deamination in Ig loci. Error-prone processing of the resultant DNA lesions is thought to cause extensive mutagenesis, but it is presently an enigma how and why error-prone rather than error-free repair pathways are recruited.
Jürgen, Bachl, Isin, Ertongur, Berit, Jungnickel   +2 more
openaire   +2 more sources