Results 21 to 30 of about 20,554 (213)
The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus [PDF]
, 2003 In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high ...
Stott, DI +11 more
core +1 more source
Somatic hypermutation signature in B-cell low-grade lymphomas
Haematologica, 2008 Background Immunoglobulin gene somatic hypermutation is a biologically relevant and clinically useful prognostic factor in different types of low-grade B-cell lymphomas, including chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal ...
Lorraine Tracey +13 more
doaj +1 more source
Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. [PDF]
PLoS Biology, 2004 Depending on the species and the lymphoid organ, activation-induced cytidine deaminase (AID) expression triggers diversification of the rearranged immunoglobulin (Ig) genes by pseudo V (psiV) gene- templated gene conversion or somatic hypermutation.
Hiroshi Arakawa +2 more
doaj +1 more source
BMC Genomics, 2021 Background Genomic localized hypermutation regions were found in cancers, which were reported to be related to the prognosis of cancers. This genomic localized hypermutation is quite different from the usual somatic mutations in the frequency of ...
Xue Lin +9 more
doaj +1 more source
Gene conversion in human rearranged immunoglobulin genes [PDF]
, 2006 Over the past 20 years, many DNA sequences have been published suggesting that all or part of the V<sub>H</sub> segment of a rearranged immunoglobulin gene may be replaced in vivo. Two different mechanisms appear to be operating. One of these
Darlow, J.M. +3 more
core +1 more source
Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers
Cell Reports, 2018 Summary: Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be optimized to elicit high-affinity, protective antibodies after vaccination.
Carolyn E. Rydyznski +6 more
doaj +1 more source
Nanopore sequencing approach for immunoglobulin gene analysis in chronic lymphocytic leukemia
Scientific Reports, 2021 The evaluation of the somatic hypermutation of the clonotypic immunoglobulin heavy variable gene has become essential in the therapeutic management in chronic lymphocytic leukemia patients.
Crescenzio Francesco Minervini +15 more
doaj +1 more source
AID and Somatic Hypermutation [PDF]
, 2010 In response to an assault by foreign organisms, peripheral B cells can change their antibody affinity and isotype by somatically mutating their genomic DNA. The ability of a cell to modify its DNA is exceptional in light of the potential consequences of genetic alterations to cause human disease and cancer. Thus, as expected, this mechanism of antibody
Robert W, Maul, Patricia J, Gearhart
openaire +2 more sources
Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: chronic activation, normal selection [PDF]
, 2006 Autoimmune diseases show high diversity in the affected organs, clinical manifestations and disease dynamics. Yet they all share common features, such as the ectopic germinal centers found in many affected tissues.
Neta S. Zuckerman +29 more
core +1 more source
Frontiers in Immunology, 2018 An important characteristic of chickens is that the antibody repertoire is based on a single framework, with diversity found mainly in the CDRs of the light and heavy chain variable regions.
Philip A. Leighton +3 more
doaj +1 more source