B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S [PDF]
iScienceSummary: The viral vector-based COVID-19 vaccine Ad26.COV2.S has been recommended by the WHO since 2021 and has been administered to over 200 million people.
Catherine Jacob-Dolan +15 more
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Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory
Frontiers in Immunology, 2017 The evidence for the reverse transcriptase mechanism of somatic hypermutation is substantial and multifactorial. In this 60th anniversary year of the publication of Sir MacFarlane Burnet’s Clonal Selection Theory, the evidence is briefly reviewed and ...
Edward J. Steele
doaj +2 more sources
The reverse transcriptase model of somatic hypermutation [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2001 The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the humanBCL–6gene can be interpreted in terms of the reverse transcriptase model and the notion of feedback of ...
Edward J Steele, Robert V Blanden
exaly +3 more sources
Somatic hypermutation generates antibody specificities beyond the primary repertoire [PDF]
ImmunityZuo T +16 more
exaly +2 more sources
Histone H2A and H2B are monoubiquitinated at AID-targeted loci. [PDF]
PLoS ONE, 2010 Somatic hypermutation introduces base substitutions into the rearranged and expressed immunoglobulin (Ig) variable regions to promote immunity. This pathway requires and is initiated by the Activation Induced Deaminase (AID) protein, which deaminates ...
Glen M Borchert +4 more
doaj +1 more source
The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Guojun Yu +2 more
exaly +2 more sources
Frontiers in Immunology, 2022 The COVID-19 pandemic shows that vaccination strategies building on an ancestral viral strain need to be optimized for the control of potentially emerging viral variants.
Lisa Paschold +11 more
doaj +1 more source
Somatic immunoglobulin hypermutation [PDF]
Current Opinion in Immunology, 2002 Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence.
Marilyn, Diaz, Paolo, Casali
openaire +2 more sources
Modulation of Pleurodeles waltl DNA polymerase mu expression by extreme conditions encountered during spaceflight. [PDF]
PLoS ONE, 2013 DNA polymerase µ is involved in DNA repair, V(D)J recombination and likely somatic hypermutation of immunoglobulin genes. Our previous studies demonstrated that spaceflight conditions affect immunoglobulin gene expression and somatic hypermutation ...
Véronique Schenten +3 more
doaj +1 more source
Impact of Chk1 dosage on somatic hypermutation in vivo [PDF]
, 2021 Checkpoint signaling in the context of a functional DNA damage response is crucial for the prevention of oncogenic transformation of cells. Our immune system, though, takes the risk of attenuated checkpoint responses during immunoglobulin diversification.
Bello, Amanda +3 more
core +1 more source