Results 11 to 20 of about 18,035 (205)
Histone H2A and H2B are monoubiquitinated at AID-targeted loci. [PDF]
PLoS ONE, 2010 Somatic hypermutation introduces base substitutions into the rearranged and expressed immunoglobulin (Ig) variable regions to promote immunity. This pathway requires and is initiated by the Activation Induced Deaminase (AID) protein, which deaminates ...
Glen M Borchert +4 more
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Frontiers in Immunology, 2022 The COVID-19 pandemic shows that vaccination strategies building on an ancestral viral strain need to be optimized for the control of potentially emerging viral variants.
Lisa Paschold +11 more
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Modulation of Pleurodeles waltl DNA polymerase mu expression by extreme conditions encountered during spaceflight. [PDF]
PLoS ONE, 2013 DNA polymerase µ is involved in DNA repair, V(D)J recombination and likely somatic hypermutation of immunoglobulin genes. Our previous studies demonstrated that spaceflight conditions affect immunoglobulin gene expression and somatic hypermutation ...
Véronique Schenten +3 more
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Somatic immunoglobulin hypermutation [PDF]
Current Opinion in Immunology, 2002 Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence.
Marilyn, Diaz, Paolo, Casali
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Somatic hypermutation signature in B-cell low-grade lymphomas
Haematologica, 2008 Background Immunoglobulin gene somatic hypermutation is a biologically relevant and clinically useful prognostic factor in different types of low-grade B-cell lymphomas, including chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal ...
Lorraine Tracey +13 more
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Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. [PDF]
PLoS Biology, 2004 Depending on the species and the lymphoid organ, activation-induced cytidine deaminase (AID) expression triggers diversification of the rearranged immunoglobulin (Ig) genes by pseudo V (psiV) gene- templated gene conversion or somatic hypermutation.
Hiroshi Arakawa +2 more
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AID and Somatic Hypermutation [PDF]
, 2010 In response to an assault by foreign organisms, peripheral B cells can change their antibody affinity and isotype by somatically mutating their genomic DNA. The ability of a cell to modify its DNA is exceptional in light of the potential consequences of genetic alterations to cause human disease and cancer. Thus, as expected, this mechanism of antibody
Robert W, Maul, Patricia J, Gearhart
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BMC Genomics, 2021 Background Genomic localized hypermutation regions were found in cancers, which were reported to be related to the prognosis of cancers. This genomic localized hypermutation is quite different from the usual somatic mutations in the frequency of ...
Xue Lin +9 more
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Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers
Cell Reports, 2018 Summary: Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be optimized to elicit high-affinity, protective antibodies after vaccination.
Carolyn E. Rydyznski +6 more
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Nanopore sequencing approach for immunoglobulin gene analysis in chronic lymphocytic leukemia
Scientific Reports, 2021 The evaluation of the somatic hypermutation of the clonotypic immunoglobulin heavy variable gene has become essential in the therapeutic management in chronic lymphocytic leukemia patients.
Crescenzio Francesco Minervini +15 more
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