Results 31 to 40 of about 20,554 (213)

Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants

Nature Communications, 2023
In this study, authors identified neutralizing antibodies by isolating B cells from SARS-CoV-2 Delta infected patients and detect altered structural features, likely introduced by somatic hypermutation, that are involved in epitope binding and increase ...
Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang   +38 more
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Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases [PDF]

, 2006
Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for ...
Gitit Shahaf, Dunn-Walters, D., Avital Steiman-Shimony, Michal Barak, Roshini S. Abraham, Ramit Mehr, Abraham, Roshini S., Mehr, Ramit, Steiman-Shimony, Avital, Barak, M., Steiman-Shimony, A., David I. Stott, Edelman, H., Edelman, Hanna, Barak, Michal, Stott, David I., Mehr, R., Shahaf, G., Dunn-Walters, Deborah, Deborah Dunn-Walters, Hanna Edelman, Shahaf, Gitit, Abraham, R.S., Stott, D.I.   +23 more
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Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4 [PDF]

, 2004
86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
Darlow, J.M., Farrell, A.M., John M. Darlow, David I. Stott, Stott, D.I., Alex M. Farrell   +5 more
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Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe

Frontiers in Immunology, 2023
The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem.
Luis Del Pozo-Yauner, Guillermo A. Herrera, Julio I. Perez Carreon, Elba A. Turbat-Herrera, Elba A. Turbat-Herrera, Francisco J. Rodriguez-Alvarez, Robin A. Ruiz Zamora   +6 more
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Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression

Haematologica, 2008
Background Follicular lymphoma is characterized by the t(14;18) translocation resulting in constitutive expression of BCL-2 protein; however approximately 10–15% of follicular lymphomas do not express BCL-2 protein, and a small fraction of these cases ...
Éva Gagyi, Zsófia Balogh, Csaba Bödör, Botond Timár, Lilla Reiniger, Linda Deák, Judit Csomor, Balázs Csernus, Ágota Szepesi, András Matolcsy   +9 more
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Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens

Frontiers in Immunology, 2022
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged continuously, challenging the effectiveness of vaccines, diagnostics, and treatments.
Matheus Oliveira de Souza, Matheus Oliveira de Souza, Bharat Madan, Bharat Madan, I-Ting Teng, Aric Huang, Lihong Liu, Ahmed S. Fahad, Sheila N. Lopez Acevedo, Xiaoli Pan, Mallika Sastry, Matias Gutierrez-Gonzalez, Michael T. Yin, Tongqing Zhou, David D. Ho, Peter D. Kwong, Peter D. Kwong, Brandon J. DeKosky, Brandon J. DeKosky, Brandon J. DeKosky, Brandon J. DeKosky   +20 more
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Role of G-quadruplexes in targeting of somatic hypermutation [PDF]

, 2021
Formation of high-affinity antibodies towards antigens is ensured with a process called somatic hypermutation, which happens during affinity maturation of activated B-cells.
Honkonen, Eveliina
core  

Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors

Frontiers in Immunology, 2018
Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination.
Alexey N. Davydov, Anna S. Obraztsova, Anna S. Obraztsova, Mikhail Y. Lebedin, Maria A. Turchaninova, Maria A. Turchaninova, Maria A. Turchaninova, Dmitriy B. Staroverov, Dmitriy B. Staroverov, Ekaterina M. Merzlyak, Ekaterina M. Merzlyak, George V. Sharonov, George V. Sharonov, Olga Kladova, Mikhail Shugay, Mikhail Shugay, Mikhail Shugay, Mikhail Shugay, Olga V. Britanova, Olga V. Britanova, Olga V. Britanova, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov   +25 more
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Restriction of AID activity and somatic hypermutation by PARP-1. [PDF]

, 2019
Affinity maturation of the humoral immune response depends on somatic hypermutation (SHM) of immunoglobulin (Ig) genes, which is initiated by targeted lesion introduction by activation-induced deaminase (AID), followed by error-prone DNA repair ...
Członka, Ewelina, Bello, Amanda, Svend K Petersen-Mahrt, Sandra Tepper, Angelika Schmidt, Pfeil, I., Schmidt, Angelika, Ines Pfeil, Mangerich, A., Ewelina Członka, Helleday, T., Oliver Mortusewicz, Amanda Bello, Fischbach, Arthur, Tepper, Sandra, Mangerich, Aswin, Jeschke, Julia, Mortusewicz, O., Heinrich Leonhardt, Schmidt, A., Jeschke, J., Thomas Helleday, Berit Jungnickel, Tepper, S., Jungnickel, B., Pfeil, Ines, Jungnickel, Berit, Petersen-Mahrt, S.K., Aswin Mangerich, Fischbach, A., Bello, A., Julia Jeschke, Członka, E., Mortusewicz, Oliver, Leonhardt, H., Arthur Fischbach   +35 more
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Characteristics of Pan-Cancer Patients With Ultrahigh Tumor Mutation Burden

Frontiers in Oncology, 2021
BackgroundTumor mutation burden has been proven to be a good predictor for the efficacy of immunotherapy, especially in patients with hypermutation. However, most research focused on the analysis of hypermutation in individual tumors, and there is a lack
Hong Yuan, Jun Ji, Min Shi, Yan Shi, Jing Liu, Junwei Wu, Chen Yang, Wenqi Xi, Qingyuan Li, Wei Zhu, Jingjie Li, Xiaoli Gong, Jun Zhang, Jun Zhang   +13 more
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