Results 81 to 90 of about 20,554 (213)
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
Nature Communications, 2018 Human memory and marginal zone B cells share some features including CD27 expression and somatic hypermutation, but their lineage relationship is still unclear.
Yuan Zhao +25 more
doaj +1 more source
American Journal of Hematology, Volume 101, Issue 8, Page 1818-1827, August 2026.ABSTRACT CD19‐directed chimeric antigen receptor (CAR) T‐cell therapy has transformed outcomes for patients with relapsed or refractory (r/r) mantle cell lymphoma (MCL), yet more than 40% relapse within one year. Early identification of patients at risk for progression could inform post CAR‐T surveillance and consolidation strategies.
Snegha Ananth +12 more
wiley +1 more source
Somatic Hypermutation of Immunoglobulin Genes Merging Mechanisms for Genetic Diversity
, 2002 Somatic hypermutation is critical for the generation of high-affinity antibodies and effective immune responses, but its molecular mechanism remains poorly understood.
Schatz, David G +3 more
core +1 more source
Clinical and Experimental Neuroimmunology, Volume 17, Issue 3, August 2026.ABSTRACT Background IgG4‐related disease (IgG4‐RD) is a systemic, immune‐mediated, fibroinflammatory disorder with multiorgan involvement and variable clinical presentation, often creating diagnostic difficulty. Myasthenia gravis (MG) is an antibody‐mediated autoimmune disorder of the neuromuscular junction, most commonly associated with anti ...
Yumiko Yoshida +4 more
wiley +1 more source
Med1 deficiency alters the somatic hypermutation spectrum in murine B cells
, 2018 The Mediator complex is known to orchestrate transcription. Here we show that B cell conditional deficient mice for the Med1 subunit display robust somatic hypermutation.
Isabelle Robert +11 more
core +1 more source
Cell Reports, 2019 Summary: Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD+IgM− plasmablasts constitute a major lymphocyte
Pedro Perdiguero +10 more
doaj +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, Volume 13, Issue 37, 3 July 2026.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
Lamarck and immunity: Somatic and germline evolution of antibody genes
, 2009 Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus
Steele, E.J.
core
, 2000 Immunoglobulins are known to be variably glycosylated. Although most carbohydrate is likely to be associated with the constant region, the variable region may also be glycosylated.
Boursier, L, Spencer, J, Dunn-Walters, D
core +1 more source
Citation: 'somatic hypermutation' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11227 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Jana Ridani +3 more
openaire +2 more sources