Results 71 to 80 of about 20,554 (213)

Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children

Nature Communications, 2017
Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand ...
Ben S. Wendel, Chenfeng He, Mingjuan Qu, Di Wu, Stefany M. Hernandez, Ke-Yue Ma, Eugene W. Liu, Jun Xiao, Peter D. Crompton, Susan K. Pierce, Pengyu Ren, Keke Chen, Ning Jiang   +12 more
doaj   +1 more source

Mutating for Good: DNA Damage Responses During Somatic Hypermutation

Frontiers in Immunology, 2019
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for affinity maturation of antibodies.
Bas Pilzecker, Heinz Jacobs
doaj   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

IgG1 memory B cells keep the memory of IgE responses

Nature Communications, 2017
IgE is an important mediator of protective immunity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses is not clear.
Jin-Shu He, Sharrada Subramaniam, Vipin Narang, Kandhadayar Srinivasan, Sean P. Saunders, Daniel Carbajo, Tsao Wen-Shan, Nur Hidayah Hamadee, Josephine Lum, Andrea Lee, Jinmiao Chen, Michael Poidinger, Francesca Zolezzi, Juan J. Lafaille, Maria A. Curotto de Lafaille   +14 more
doaj   +1 more source

Directed molecular evolution by somatic hypermutation [PDF]

Protein Engineering Design and Selection, 2004
After rearrangement of immunoglobulin gene segments, the immune system evolves the antibody repertoire by mutating the immunoglobulin variable region at a high rate. While this somatic hypermutation was thought to occur only at the variable region, recent studies suggest that hypermutation can occur at locations throughout the genome.
Clifford L, Wang, Desirée C, Yang, Matthias, Wabl   +2 more
openaire   +2 more sources

High‐density mutation tracks are associated with proton‐beam irradiation patterns in Sorghum bicolor

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Induced mutagenesis is a cornerstone of crop functional genomics, yet the extent to which distinct radiation sources reshape the spatial distribution of mutations remains difficult to evaluate in reduced‐representation datasets. Here, we analyze a published genotyping‐by‐sequencing (GBS) panel (192,040 loci) to compare proton‐beam and gamma ...
Ezekiel Ahn, Insuck Baek, Seunghyun Lim, Louis K. Prom, Moon S. Kim, Lyndel W. Meinhardt, Clint Magill   +6 more
wiley   +1 more source

Measured somatic hypermutation levels from UCA or MRCA reach substitution saturation during antibody development.

, 2016
To demonstrate the dynamic changes of somatic hypermutation level (SHM) over time, the mean and 95% confidence interval of SHM was calculated for each time point of the three lineages.
Zizhang Sheng (280791), Lynn Morris (7883), Chaim A. Schramm (2794135), Mark Connors (229169), John R. Mascola (229761), Peter D. Kwong (161423), Lawrence Shapiro (2794138)   +6 more
core   +1 more source

Secondary Mechanisms of Affinity Maturation in the Human Antibody Repertoire

Frontiers in Immunology, 2013
V(D)J recombination and somatic hypermutation (SHM) are the primary mechanisms for diversification of the human antibody repertoire. These mechanisms allow for rapid humoral immune responses to a wide range of pathogenic challenges.
Bryan S. Briney, James E. Crowe
doaj   +1 more source

DNA repair in antibody somatic hypermutation [PDF]

Trends in Immunology, 2006
Somatic hypermutation (SHM) underlies the generation of a diverse repertoire of high-affinity antibodies. It is effected by a two-step process: (i) DNA lesions initiated by activation-induced cytidine deaminase (AID), and (ii) lesion repair by the combined intervention of DNA replication and repair factors that include mismatch repair (MMR) proteins ...
Paolo, Casali, Zsuzsanna, Pal, Zhenming, Xu, Hong, Zan   +3 more
openaire   +2 more sources

Decoding the Black Box of Fish Vaccines Efficacy in Basic and Applied Contexts

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
ABSTRACT Vaccines are the frontline defense in aquaculture, yet predicting their real‐world performance remains a tricky puzzle. Unlike terrestrial veterinary vaccines, fish vaccines largely operate through “Black Box” processes, where we observe the outcomes but rarely understand the underlying immune mechanisms. Laboratory trials, though informative,
Jiří Kyslík, Mikolaj Adamek, Tomáš Korytář   +2 more
wiley   +1 more source