Results 121 to 130 of about 20,554 (213)

Mutational Analysis of 48G7 Reveals that Somatic Hypermutation Affects Both Antibody Stability and Binding Affinity

, 2016
The monoclonal antibody 48G7 differs from its germline precursor by 10 somatic mutations, a number of which appear to be functionally silent. We analyzed the effects of individual somatic mutations and combinations thereof on both antibody binding ...
Thomas J. Magliery (587041), Nam-Jung Kim (1480939), Feng Wang (44414), Sophie B. Sun (1983196), Peter G. Schultz (183240), Shiladitya Sen (1937458)   +5 more
core   +1 more source

Mechanism of Mismatch Repair Induced Mutagenesis in Somatic Hypermutation

, 2010
B cells produce a diverse array of antibody specificities that are of low affinity during the initial phase of a humoral immune response. However, somatic hypermutation of the rearranged V region in the immunoglobulin locus generates new antibody ...
Frieder, Darina
core   +1 more source

A somatic hypermutation-based machine learning model stratifies individuals with Crohn's disease and controls. [PDF]

Genome Res, 2023
Safra M, Werner L, Peres A, Polak P, Salamon N, Schvimer M, Weiss B, Barshack I, Shouval DS, Yaari G.   +9 more
europepmc   +1 more source

Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments

, 2003
Somatic hypermutation (SHM) introduces mutations into immunoglobulin (Ig) variable gene segments, thus diversifying the B cell repertoire prior to positive selection of high affinity variants during maturation of T cell-dependent B cell responses ...
Boursier, L, Wen Su, Su, W, Spencer, J, Jo Spencer, Laurent Boursier   +5 more
core   +1 more source

Single-Step IGHV Next-Generation Sequencing Detects Clonality and Somatic Hypermutation in Lymphoid Malignancies: A Phase III Diagnostic Accuracy Study. [PDF]

Cancers (Basel), 2023
Gazzola A, Navari M, Mannu C, Donelli R, Etebari M, Piccaluga PP.   +5 more
europepmc   +1 more source

Antigen receptors and somatic hypermutation in B-cell chronic lymphocytic leukemia with Richter's transformation

, 2006
BACKGROUND AND OBJECTIVES: Activation-induced cytidine deaminase is essential for somatic hypermutation and class switch recombination of the immunoglobulin genes in B cells.
van Noesel, Carel J. M., Langerak, Ton, Smit, LA, Langerak, Anton W., de Wit, MJ, van Maldegem, F, van Noesel, CJM, Bende, RJ, Campo, E, Bende, Richard J., van der Schoot, CE, van der Schoot, C. Ellen, de Wit, Mireille J., Campo, Elias, Smit, Laura A., Bea, S, van Maldegem, Febe, Bea, Silvia   +17 more
core  

Histone Modifications Associated with Somatic Hypermutation

, 2005
SummaryA number of modified histones, including acetylated H3 and H4 and phosphorylated H2AX (γH2AX), are associated with V(D)J recombination and class switch recombination (CSR).
Anderson, Shannon M., Shlomchik, Mark J., Kim, Sean T., Odegard, Valerie H., Schatz, David G.   +4 more
core   +1 more source

The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation. [PDF]

Front Immunol, 2023
Martin OA, Thomas M, Marquet M, Bruzeau C, Garot A, Brousse M, Bender S, Carrion C, Choi JE, Vuong BQ, Gearhart PJ, Maul RW, Le Noir S, Pinaud E.   +13 more
europepmc   +1 more source

Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation. [PDF]

Front Immunol, 2021
Sheng Z, Bimela JS, Katsamba PS, Patel SD, Guo Y, Zhao H, Guo Y, Kwong PD, Shapiro L.   +8 more
europepmc   +1 more source

Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity. [PDF]

Front Oncol, 2022
Sofou E, Zaragoza-Infante L, Pechlivanis N, Karakatsoulis G, Notopoulou S, Stavroyianni N, Psomopoulos F, Georgiou E, de Septenville AL, Davi F, Agathangelidis A, Chatzidimitriou A, Stamatopoulos K.   +12 more
europepmc   +1 more source