Results 121 to 130 of about 18,035 (205)

The Developmental and Functional Implications of Age‐Associated B Cells (ABCs) Across Tissue Microenvironments

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Age‐associated B cells (ABCs) are a dynamic B cell subset whose identity, development, and function are fundamentally shaped by the tissue microenvironments in which they reside. Primarily defined by expression of CD11c and T‐bet, ABCs arise across diverse contexts, including aging, infection, autoimmunity, and cancer, yet exhibit striking ...
Rebecca L. Francis, Jason S. Weinstein
wiley   +1 more source

The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2. [PDF]

Emerg Microbes Infect, 2022
Tian X, Zhu X, Song W, Yang Z, Wu Y, Ying T.   +5 more
europepmc   +1 more source

Somatic Hypermutation [PDF]

, 2020
openaire   +1 more source

DNA Methylation Profiling in IDH‐Mutant Gliomas: Biological Evolution, Molecular Grading and Clinical Implementation

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
Mutant IDH1/2 produces D‐2‐hydroxyglutarate, establishing the G‐CIMP methylation phenotype while permitting epigenetic evolution during glioma progression. DNA methylation profiling supports tumour classification, lower‐ versus high‐grade subclassification and broad copy‐number assessment, but A_IDH_HG/G‐CIMP‐low signatures must be integrated with ...
Pietro Tralongo, Gabriele Ricciardi, Mariagiovanna Ballato, Vincenzo Fiorentino, Valeria Zuccalà, Giorgia Castellani, Quintino Giorgio D'Alessandris, Guido Fadda, Lucia Ricci‐Vitiani, Maria Caffo, Maurizio Martini   +10 more
wiley   +1 more source

SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis. [PDF]

Cancer Discov, 2022
Leung W, Teater M, Durmaz C, Meydan C, Chivu AG, Chadburn A, Rice EJ, Muley A, Camarillo JM, Arivalagan J, Li Z, Flowers CR, Kelleher NL, Danko CG, Imielinski M, Dave SS, Armstrong SA, Mason CE, Melnick AM.   +18 more
europepmc   +1 more source

Light Chain Crystalline Proximal Tubulopathy and Podocytopathy With Staining for Both Light and Heavy Chain Immunoglobulin

Nephrology, Volume 31, Issue 8, August 2026.
ABSTRACT A 69‐year‐old male patient presented with weight loss and proteinuria. His medical history included papillary thyroid carcinoma. Laboratory findings showed proteinuria and high κ light chain levels in both urine and serum. Bone marrow aspiration revealed plasma cell myeloma of the IgA‐κ type.
Seoyoung Choi, Kyung Chul Moon
wiley   +1 more source

Adenoviral Inciting Antigen and Somatic Hypermutation in VITT. [PDF]

N Engl J Med
Wang JJ, Schönborn L, Warkentin TE, Müller L, Thiele T, Ulm L, Völker U, Ameling S, Franzenburg S, Kaderali L, Tzvetkova A, Colella A, Chataway T, Tan CW, Armour B, Troelnikov A, Rutten L, McCluskey J, Zahn R, Gordon TP, Greinacher A.   +20 more
europepmc   +1 more source

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation. [PDF]

Front Immunol, 2022
Spanjaard A, Stratigopoulou M, de Groot D, Aslam M, van den Berk PCM, Stappenbelt C, Ayidah M, Catsman JJI, Pardieck IN, Kreft M, Arens R, Guikema JEJ, Jacobs H.   +12 more
europepmc   +1 more source

The immunity paradox: how do plants survive without adaptive immunity?

The Plant Journal, Volume 127, Issue 3, August 2026.
SUMMARY Higher plants and mammals exist in similar microbial environments and face similar challenges from microbial pathogens. Both taxonomic groups encode proteins capable of recognizing and triggering responses to pathogens; however, their recognitional capacities differ substantially.
Peter Balint‐Kurti
wiley   +1 more source

Comparative evaluation of two NGS-based assays for somatic hypermutation analysis of IGHV genes in chronic lymphocytic leukemia. [PDF]

Blood Res
Kang Y, Lee H, Park YJ, Lee ST, Choi JR, Shin S.   +5 more
europepmc   +1 more source