Results 81 to 90 of about 142,252 (275)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Elevated arousal at time of decision-making is not the arbiter of risk avoidance in chickens [PDF]

, 2015
The somatic marker hypothesis proposes that humans recall previously experienced physiological responses to aid decision-making under uncertainty. However, little is known about the mechanisms used by non-human animals to integrate risk perception with ...
A Bechara, A Bechara, A Bechara, AC Davies, AC Davies, AL Krain, AR Damasio, B Studer, CJ Burke, DJ McFarland, EA Crone, GF Loewenstein, HD Critchley, I Cuthill, JA Weller, JC Lowe, JL Edgar, JL Edgar, L Chittka, M Mendl, PC Trimmer, PH Zimmerman, RO Moe, RO Moe, S Korte, SL Lima, T Caraco, WJ Browne, X Cerda   +28 more
core   +4 more sources

Identification of side population cells in mouse primordial germ cells and prenatal testis [PDF]

, 2011
In mammals, the stem cells of spermatogenesis are derived from an embryonic cell population called primordial germ cells (PGCs). Spermatogonial stem cells displaying the "side population" (SP) phenotype have been identified in the immature and adult ...
De Felici, Massimo, Fera, Stefania, Grisanti, Laura, Lucia Scaldaferri, Maria, Sanchez, Massimo, Stefanini, Mario, Vicini, Elena   +6 more
core   +2 more sources

THE SOMATIC MARKER HYPOTHESIS AND THE NEUROBIOLOGY OF DECISIONS

, 2019
The somatic marker hypothesis (SMH) has been one of the most influential theories in the neurosciences since the early 1990s, when it was formulated by Antonio Damasio in his book Descartes’ Error (1994). Since then, various studies, for and against, have been written without a verdict.
openaire   +1 more source

Vagal signaling and the somatic marker hypothesis: The effect of transcutaneous vagal nerve stimulation on delay discounting is modulated by positive mood

International Journal of Psychophysiology, 2020
Controlling impulsivity and delaying gratifications are key features of effective self-control. Delay Discounting (DD) indexes the ability to delay rewards and previous research has shown that discounting is influenced by affective states such as mood. According to the Somatic Marker Hypothesis (SMH), afferent somatic signals, such as mood, are carried
Steenbergen, L., Colzato, L.S., Maraver, M.J.   +2 more
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Decision Making Profile of Positive and Negative Anticipatory Skin Conductance Responders in an Unlimited-Time Version of the IGT

Frontiers in Psychology, 2019
Based on the somatic marker hypothesis (Damasio, 1994), many studies have examined whether or not physiological responses are “somatic markers” that implicitly guide the decision making process. Vegetative or motor reactions that are produced by negative
Ana Merchán-Clavellino, María P. Salguero-Alcañiz, Fernando Barbosa, Jose R. Alameda-Bailén   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Normatively irrelevant disgust interferes with decision under uncertainty: Insights from the Iowa gambling task.

PLoS ONE
This study investigates whether a not informative, irrelevant emotional reaction of disgust interferes with decision-making under uncertainty. We manipulate the Iowa Gambling Task (IGT) by associating a disgust-eliciting image with selections from ...
Giulia Priolo, Marco D'Alessandro, Andrea Bizzego, Laura Franchin, Nicolao Bonini   +4 more
doaj   +1 more source

Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine [PDF]

, 2011
Embryonic stem (ES) cells are of great interest as a model system for studying early developmental processes and because of their potential therapeutic applications in regenerative medicine.
Kim, Jonghwan, Orkin, Stuart
core   +1 more source