Results 81 to 90 of about 746,068 (249)

Overlap in somatic mutation calls.

, 2013
Verified somatic mutation calls were compared across three callers in 5 different tumor purity mixtures. Values are number of calls in 100%, 80%, 60%, 40% and 20% tumor content mixture, from top to bottom.
Suzanne Manning (481821), Nicola Waddell (481824), Jianmin Wu (19537), Anthony J. Gill (132630), Timothy J. Bruxner (481818), Ehsan Nourbakhsh (16631), Oliver Holmes (132636), Shivangi Wani (481822), Amber L. Johns (132632), Darrin Taylor (16118), David K. Chang (190035), Lynn Fink (132661), Scott Wood (132640), Peter J. Wilson (85965), Senel Idrisoglu (481819), Katia Nones (132620), Andrew V. Biankin (81390), Craig Nourse (481820), Anita Steptoe (481823), Ann-Marie Patch (481815), Mark Pinese (52475), David K. Miller (481816), Felicity Newell (132648), Ivon Harliwong (132623), Sarah Song (132618), Karin S. Kassahn (132626), Conrad Leonard (132638), Mark J. Cowley (107519), Sean M. Grimmond (132666), John V. Pearson (67320), Qinying Xu (132643), Marina Pajic (132629), Angelika N. Christ (481817), Matthew Anderson (132634)   +33 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study

BMC Cancer, 2019
Introduction Multiple primary melanomas (MPM) occur up to 8% of patients with cutaneous malignant melanoma (CMM). They are often sporadic harbouring several somatic mutations, but also familial cases harbouring a CDKN2A germline mutation have been ...
Milena Casula, Panagiotis Paliogiannis, Fabrizio Ayala, Vincenzo De Giorgi, Ignazio Stanganelli, Mario Mandalà, Maria Colombino, Antonella Manca, Maria Cristina Sini, Corrado Caracò, Paolo Antonio Ascierto, Rosanna Rita Satta, Melanoma Unit of Sassari (MUS), Amelia Lissia, Antonio Cossu, Giuseppe Palmieri, for the Italian Melanoma Intergroup (IMI)   +16 more
doaj   +1 more source

The Somatic Mutation Hit on Top of Genetic APC mutations Cause Skin Tumor

Translational Oncology, 2020
Inactivation of the adenomatous polyposis coli (APC) gene is the initiating event in familial adenomatous polyposis (FAP) patients. Up to 90% of FAP patients show intestinal tumors and other extracolonic malignancies including hepatoblastomas, desmoid ...
Ting Niu, Mingming Yang, Qing Liu, Haobin Li, Lingbi Jiang, Fanggu Li, Xiaodong He, Lijing Wang, Jiangchao Li   +8 more
doaj   +1 more source

Gene expression analyses on skin lesions from patients with familial adenomatous polyposis [PDF]

, 2014
Familial adenomatous polyposis coli (FAP) is an autosomal dominant colorectal cancer predisposition syndrome caused by germline mutations in the APC gene.
Stegmann, Danielle Alexandra
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cancer as a Mitochondrial Metabolic Disease

Frontiers in Cell and Developmental Biology, 2015
Cancer is widely considered a genetic disease involving nuclear mutations in oncogenes and tumor suppressor genes. This view persists despite the numerous inconsistencies associated with the somatic mutation theory.
Thomas N Seyfried
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Somatic mutation rates scale with time not growth rate in long-lived tropical trees

eLife
The rates of appearance of new mutations play a central role in evolution. However, mutational processes in natural environments and their relationship with growth rates are largely unknown, particular in tropical ecosystems with high biodiversity. Here,
Akiko Satake, Ryosuke Imai, Takeshi Fujino, Sou Tomimoto, Kayoko Ohta, Mohammad Na'iem, Sapto Indrioko, Widiyatno Widiyatno, Susilo Purnomo, Almudena Molla Morales, Viktoria Nizhynska, Naoki Tani, Yoshihisa Suyama, Eriko Sasaki, Masahiro Kasahara   +14 more
doaj   +1 more source