Results 121 to 130 of about 1,861,621 (385)

The real war on cancer: the evolutionary dynamics of cancer suppression. [PDF]

, 2012
Cancer is a disease of multicellular animals caused by unregulated cell division. The prevailing model of cancer (multistage carcinogenesis) is based on the view that cancer results after a series of (generally somatic) mutations that knock out the ...
Nunney, Leonard
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas. [PDF]

, 2016
Malignant pleural mesothelioma (MPM), a rare malignancy with a poor prognosis, is mainly caused by exposure to asbestos or other organic fibers, but the underlying genetic mechanism is not fully understood.
Fang, Li Tai, Jablons, David M, Jen, Kuang-Yu, Jones, Kirk, Kang, Hio Chung, Kim, Hong Kwan, Kim, Il-Jin, Kim, James Wansoo, Lee, Sharon, Mendez, Pedro, Woodard, Gavitt, Yoon, Jun-Hee   +11 more
core   +3 more sources

High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations

Brain : a journal of neurology, 2018
Brain and spinal arteriovenous malformations are congenital lesions causing intracranial haemorrhage or permanent disability especially in young people.
T. Hong, Yupeng Yan, Jingwei Li, I. Radovanovic, Xiangyuan Ma, Y. Shao, Jiaxing Yu, Yongjie Ma, Peng Zhang, F. Ling, Shucheng Huang, Hongqi Zhang, Yibo Wang   +12 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Significance of somatic mutations and content alteration of mitochondrial DNA in esophageal cancer

BMC Cancer, 2006
Background The roles of mitochondria in energy metabolism, the generation of ROS, aging, and the initiation of apoptosis have implicated their importance in tumorigenesis. In this study we aim to establish the mutation spectrum and to understand the role
Wang Yu-Fen, Bai Ren-Kui, Liu Ling-Ling, Chang Julia, Tan Duan-Jun, Yeh Kun-Tu, Wong Lee-Jun C   +6 more
doaj   +1 more source

Computational Cancer Biology: An Evolutionary Perspective [PDF]

, 2016
ISSN:1553-734XISSN:1553 ...
A Deutsch, A Fischer, A Gonzalez-Perez, A Roth, A Schuh, A Tofigh, A Trinh, AM Newman, BJ Raphael, C Guichard, C Tomasetti, C Tomasetti, CD Greenman, Chris D. Greenman, CO Nordling, CS Cooper, CS-O Attolini, E Purdom, E Szczurek, ER Fearon, F Michor, F Ronquist, F Strino, F Vandin, H Shahrabi Farahani, H Zare, I Bozic, I Bozic, I Martincorena, J Diaz, J Foo, J Rahnenführer, J Shendure, Jens Lagergren, JH Goldie, K Yuan, KI Kim, L Oesper, LJ Barber, LMF Merlo, LR Yates, M Consequences, M Gerlinger, M Gerstung, M Gerstung, M Gerstung, M Hjelm, M Kimmel, MDM Leiserson, MDM Leiserson, MDM Leiserson, MF Berger, MS Lawrence, N Beerenwinkel, N Beerenwinkel, N Beerenwinkel, N Crosetto, N Navin, NE Navin, Niko Beerenwinkel, P Armitage, P Eirew, P Haccou, PC Nowell, PS Larson, R Desper, R Durrett, RF Schwarz, Ruth Nussinov, S Constantinescu, S Nik-Zainal, S Nik-Zainal, S Turajlic, S Turajlic, SA Chowdhury, SA Chowdhury, SE Luria, T Sakoparnig, V Almendro, W Jiao, WJ Ewens, Y Iwasa   +81 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Integrating germline and somatic variation information using genomic data for the discovery of biomarkers in prostate cancer

BMC Cancer, 2019
Background Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the United States.
Tarun Karthik Kumar Mamidi, Jiande Wu, Chindo Hicks   +2 more
doaj   +1 more source

Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients

Nature Communications, 2018
Deregulation of the phosphoinositide 3-kinase (PI3K) pathway contributes to the development and progression of tumors. Here, we determine that somatic mutations in PIK3CA (44%), PIK3R1 (17%), AKT3 (15%), and PTEN (12%) are prevalent and diverse in ...
Li Chen, Liu Yang, L. Yao, X. Kuang, W. Zuo, Shan Li, Feng Qiao, Yirong Liu, Z. Cao, Shu-Ling Zhou, Xiao‐yan Zhou, Wen-tao Yang, Jin-xiu Shi, Wei Huang, Xin Hu, Z. Shao   +15 more
semanticscholar   +1 more source