Results 11 to 20 of about 1,861,621 (385)
Somatic Mutations and Autoimmunity [PDF]
Cells, 2021 Autoimmune diseases are among the most common chronic illness caused by a dysregulated immune response against self-antigens. Close to 5% of the general population in Western countries develops some form of autoimmunity, yet its underlying causes ...
Maha Alriyami, Constantin Polychronakos
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Somatic Mutations in Cardiovascular Disease [PDF]
Circulation Research, 2022 Advances in population-scale genomic sequencing have greatly expanded the understanding of the inherited basis of cardiovascular disease (CVD). Reanalysis of these genomic datasets identified an unexpected risk factor for CVD, somatically acquired DNA mutations. In this review, we provide an overview of somatic mutations and their contributions to CVD.
J. Brett Heimlich, Alexander G. Bick
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QuaDMutEx: quadratic driver mutation explorer [PDF]
BMC Bioinformatics, 2017 Background Somatic mutations accumulate in human cells throughout life. Some may have no adverse consequences, but some of them may lead to cancer. A cancer genome is typically unstable, and thus more mutations can accumulate in the DNA of cancer cells ...
Yahya Bokhari, Tomasz Arodz
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Association analysis using somatic mutations. [PDF]
PLoS Genetics, 2018 Somatic mutations drive the growth of tumor cells and are pivotal biomarkers for many cancer treatments. Genetic association analysis using somatic mutations is an effective approach to study the functional impact of somatic mutations.
Yang Liu, Qianchuan He, Wei Sun
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Brain somatic mutations in Alzheimer’s disease: linking genetic mosaicism to neurodegeneration [PDF]
Molecular NeurodegenerationSomatic mutations are DNA sequence changes that occur in non-reproductive cells during an organism’s life and are not inherited by offspring. Growing evidence implicates somatic mutations in Alzheimer’s disease (AD), linking them to both disease onset ...
Zuguang Li +11 more
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SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering [PDF]
, 2015 Background: With the advances in high throughput technologies, increasing amounts of cancer somatic mutation data are being generated and made available.
Jimmy Van den Eynden +3 more
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Characterizing somatic mutations in ovarian cancer germline risk regions [PDF]
Communications BiologyEpithelial ovarian cancer (EOC) genetics research has been focused on germline or somatic mutations independently. Emerging evidence suggests that the somatic mutational landscape can be shaped by the germline genetic background. In this study, we aim to
Ping-Hung Lai +5 more
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Characteristics of Germline and Somatic Mutations of DNA Repair Genes in Korean Men with Prostate Cancer [PDF]
The World Journal of Men's HealthPurpose: While the association between defect of DNA damage repair (DDR) genes and prostate cancer (PCa) risk is wellestablished, there has been a lack of data in East Asian population.
Hakmin Lee +8 more
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Integrative analysis of somatic mutations altering microRNA targeting in cancer genomes. [PDF]
PLoS ONE, 2012 Determining the functional impact of somatic mutations is crucial to understanding tumorigenesis and metastasis. Recent sequences of several cancers have provided comprehensive lists of somatic mutations across entire genomes, enabling investigation of ...
Jesse D Ziebarth +2 more
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