Results 11 to 20 of about 199,006 (315)

The vast majority of somatic mutations in plants are layer-specific [PDF]

Genome Biology
Background Plant meristems are structured organs consisting of distinct layers of stem cells, which differentiate into new plant tissue. Mutations in meristematic layers can propagate into large sectors of the plant.
Manish Goel, José A. Campoy, Kristin Krause, Lisa C. Baus, Anshupa Sahu, Hequan Sun, Birgit Walkemeier, Magdalena Marek, Randy Beaudry, David Ruiz, Bruno Huettel, Korbinian Schneeberger   +11 more
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Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism

Frontiers in Endocrinology, 2023
BackgroundPrimary aldosteronism (PA) is the leading cause of curable endocrine hypertension, which is associated with a higher risk of cardiovascular and metabolic insults compared to essential hypertension. Aldosterone-producing adenoma (APA) is a major
Yi-Yao Chang, Yi-Yao Chang, Bo-Ching Lee, Zheng-Wei Chen, Cheng-Hsuan Tsai, Chin-Chen Chang, Che-Wei Liao, Chien-Ting Pan, Kang-Yung Peng, Chia-Hung Chou, Ching-Chu Lu, Vin-Cent Wu, Chi-Sheng Hung, Chi-Sheng Hung, Yen-Hung Lin, Yen-Hung Lin, TAIPAI study group   +16 more
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A pathway-centric survey of somatic mutations in Chinese patients with colorectal carcinomas. [PDF]

PLoS ONE, 2015
Previous genetic studies on colorectal carcinomas (CRC) have identified multiple somatic mutations in four candidate pathways (TGF-β, Wnt, P53 and RTK-RAS pathways) on populations of European ancestry.
Chao Ling, Lin Wang, Zheng Wang, Luming Xu, Lifang Sun, Hui Yang, Wei-Dong Li, Kai Wang   +7 more
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High prevalence of low-allele-fraction somatic mutations in STAT3 in peripheral blood CD8+ cells in multiple sclerosis patients and controls

PLoS ONE, 2022
Somatic mutations have a central role in cancer, but there are also a few rare autoimmune diseases in which somatic mutations play a major role. We have recently shown that nonsynonymous somatic mutations with low allele fractions are preferentially ...
Miko Valori, Joonas Lehikoinen, Lilja Jansson, Jonna Clancy, Sofie A. Lundgren, Satu Mustjoki, Pentti Tienari   +6 more
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Assessment of somatic mutations in urine and plasma of Wilms tumor patients

Cancer Medicine, 2020
Tumor DNA has been detected in body fluids of cancer patients. Somatic tumor mutations are being used as biomarkers in body fluids to monitor chemotherapy response as a minimally invasive tool.
Ana Carolina Kerekes Miguez, Bruna D. de Figueiredo Barros, Jorge E. S. deSouza, Cecília Maria L. daCosta, Isabela Werneck Cunha, Paula Nicole Vieira P. Barbosa, Maria Lúcia P. Apezzato, Sandro J. deSouza, Dirce Maria Carraro   +8 more
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Somatic Mutations in Fruit Trees: Causes, Detection Methods, and Molecular Mechanisms

Plants, 2023
Somatic mutations are genetic changes that occur in non-reproductive cells. In fruit trees, such as apple, grape, orange, and peach, somatic mutations are typically observed as “bud sports” that remain stable during vegetative propagation.
Seunghyun Ban, Je Hyeong Jung
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Confidence-based somatic mutation evaluation and prioritization.

PLoS Computational Biology, 2012
Next generation sequencing (NGS) has enabled high throughput discovery of somatic mutations. Detection depends on experimental design, lab platforms, parameters and analysis algorithms.
Martin Löwer, Bernhard Y Renard, Jos de Graaf, Meike Wagner, Claudia Paret, Christoph Kneip, Ozlem Türeci, Mustafa Diken, Cedrik Britten, Sebastian Kreiter, Michael Koslowski, John C Castle, Ugur Sahin   +12 more
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Germline and somatic mtDNA mutations in mouse aging. [PDF]

PLoS ONE, 2018
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans.
Hong Ma, Yeonmi Lee, Tomonari Hayama, Crystal Van Dyken, Nuria Marti-Gutierrez, Ying Li, Riffat Ahmed, Amy Koski, Eunju Kang, Hayley Darby, Thanasup Gonmanee, Younjung Park, Don P Wolf, Chong Jai Kim, Shoukhrat Mitalipov   +14 more
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Somatic Mutation and Autoimmunity [PDF]

Cell, 2007
Upon reading Christopher Goodnow's recent Review article in Cell, which emphasized the overlapping role of somatic mutation in autoimmunity and cancer (Goodnow, 2007), I was reminded of a graduate lecture course given by Professor Roderick MacLeod in 1995 at the University of Illinois. While introducing F.M.
openaire   +2 more sources

QuaDMutEx: quadratic driver mutation explorer

BMC Bioinformatics, 2017
Background Somatic mutations accumulate in human cells throughout life. Some may have no adverse consequences, but some of them may lead to cancer. A cancer genome is typically unstable, and thus more mutations can accumulate in the DNA of cancer cells ...
Yahya Bokhari, Tomasz Arodz
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