Results 31 to 40 of about 199,006 (315)
Propagation of weakly advantageous mutations in cancer cell population [PDF]
arXiv, 2023 Research into somatic mutations in cancer cell DNA and their role in tumour growth and progression between successive stages is crucial for improving our understanding of cancer evolution. Mathematical and computer modelling can provide valuable insights into the scenarios of cancer growth, the roles of somatic mutations, and the types and strengths of
arxiv
Somatic driver mutations in melanoma [PDF]
Cancer, 2017 Melanoma has one of the highest somatic mutational burdens among solid malignancies. Although the rapid progress in genomic research has contributed immensely to our understanding of the pathogenesis of melanoma, the clinical significance of the vast array of genomic alterations discovered by next‐generation sequencing is far from being fully ...
Bobby Y. Reddy +3 more
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The adaptive potential of non-heritable somatic mutations [PDF]
The American Naturalist, 2021 AbstractNon-heritable somatic mutations are typically associated with deleterious effects such as in cancer and senescence, so their role in adaptive evolution has received little attention. However, most somatic mutations are harmless and some even confer a fitness advantage to the organism carrying them.
Joshua L. Payne +4 more
openaire +5 more sources
Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1. [PDF]
PLoS ONE, 2017 The growth behaviors of cutaneous neurofibromas in patients with Neurofibromatosis type 1 are highly variable. The role of the germline NF1 mutation, somatic NF1 mutation and mutations at modifying loci, are poorly understood.
Daniel L Faden +4 more
doaj +1 more source
Somatic mutations in neurodegeneration: An update
Neurobiology of Disease, 2020 Mosaicism, the presence of genomic differences between cells due to post-zygotic somatic mutations, is widespread in the human body, including within the brain. A role for this in neurodegenerative diseases has long been hypothesised, and technical developments are now allowing the question to be addressed in detail.
openaire +4 more sources
Scientific Reports, 2023 A hallmark of cancer is a tumor cell’s ability to evade immune destruction. Somatic mutations in tumor cells that prevent immune destruction have been extensively studied.
Ramu Anandakrishnan +5 more
doaj +1 more source
Identification of Somatic Mutations From Bulk and Single-Cell Sequencing Data
Frontiers in Aging, 2022 Somatic mutations are DNA variants that occur after the fertilization of zygotes and accumulate during the developmental and aging processes in the human lifespan.
August Yue Huang, Eunjung Alice Lee
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Utilizing Protein Structure to Identify Non-Random Somatic Mutations [PDF]
, 2013 Motivation: Human cancer is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes within the genome. In the case of oncogenes, recent theory suggests that there are only a few key "driver" mutations responsible for tumorigenesis. As there have been significant pharmacological successes in developing drugs that treat cancers
arxiv +1 more source
Hierarchical Bayesian analysis of somatic mutation data in cancer [PDF]
Annals of Applied Statistics 2013, Vol. 7, No. 2, 883-903, 2013 Identifying genes underlying cancer development is critical to cancer biology and has important implications across prevention, diagnosis and treatment. Cancer sequencing studies aim at discovering genes with high frequencies of somatic mutations in specific types of cancer, as these genes are potential driving factors (drivers) for cancer development.
arxiv +1 more source
Cancer Medicine, 2023 Background We explore the utility of TruSight Tumor 170 panel (TST170) for detecting somatic mutations in tumor and cfDNA from locoregional recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC).
Óscar Rapado‐González +12 more
doaj +1 more source